Zobrazeno 1 - 10
of 100
pro vyhledávání: '"F. Donelson Smith"'
Autor:
Thomas Thisted, F. Donelson Smith, Arnab Mukherjee, Yuliya Kleschenko, Feng Feng, Zhi-Gang Jiang, Timothy Eitas, Kanam Malhotra, Zuzana Biesova, Adejumoke Onumajuru, Faith Finley, Anokhi Cifuentes, Guolin Zhang, Gaëlle H. Martin, Yoshiko Takeuchi, Kader Thiam, Robert D. Schreiber, Edward H. van der Horst
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VIST
Externí odkaz:
https://doaj.org/article/5baa81963d6e484cb872b3eac39edd59
Autor:
Sophia M. Lauer, Mitchell H. Omar, Martin G. Golkowski, Heidi L. Kenerson, Kyung-Soon Lee, Bryan C. Pascual, Huat C. Lim, Katherine Forbush, F. Donelson Smith, John D. Gordan, Shao-En Ong, Raymond S. Yeung, John D. Scott
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113678- (2024)
Summary: The DNAJ-PKAc fusion kinase is a defining feature of fibrolamellar carcinoma (FLC). FLC tumors are notoriously resistant to standard chemotherapies, with aberrant kinase activity assumed to be a contributing factor. By combining proximity pr
Externí odkaz:
https://doaj.org/article/0017dacb347145b2ba79f18c4ba57c47
Publikováno v:
Antibodies, Vol 12, Iss 3, p 55 (2023)
Immune checkpoints and other immunoregulatory targets can be difficult to precisely target due to expression on non-tumor immune cells critical to maintaining immune homeostasis in healthy tissues. On-target/off-tumor binding of therapeutics results
Externí odkaz:
https://doaj.org/article/0e0955ff91804c98a568f65c79a9c7e1
Autor:
Paula J Bucko, Chloe K Lombard, Lindsay Rathbun, Irvin Garcia, Akansha Bhat, Linda Wordeman, F Donelson Smith, Dustin J Maly, Heidi Hehnly, John D Scott
Publikováno v:
eLife, Vol 8 (2019)
Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments. W
Externí odkaz:
https://doaj.org/article/0ba69f49111048bc8e8df7812b20c536
Autor:
Rigney E Turnham, F Donelson Smith, Heidi L Kenerson, Mitchell H Omar, Martin Golkowski, Irvin Garcia, Renay Bauer, Ho-Tak Lau, Kevin M Sullivan, Lorene K Langeberg, Shao-En Ong, Kimberly J Riehle, Raymond S Yeung, John D Scott
Publikováno v:
eLife, Vol 8 (2019)
Fibrolamellar carcinoma (FLC) is a rare liver cancer. FLCs uniquely produce DNAJ-PKAc, a chimeric enzyme consisting of a chaperonin-binding domain fused to the Cα subunit of protein kinase A. Biochemical analyses of clinical samples reveal that a un
Externí odkaz:
https://doaj.org/article/df0373e02b8847ebb7435e13a15b41eb
Publikováno v:
2022 IEEE Real-Time Systems Symposium (RTSS).
Autor:
Aiping Bai, Elise Renahan, Kanam Malhotra, Thomas Thisted, F. Donelson Smith, Robert H Pierce, Edward H van der Horst
Publikováno v:
Cancer Research. 83:4645-4645
Background CD39 expression is upregulated in the tumor microenvironment (TME), which is characterized by high levels of extracellular ATP (eATP) and low pH. CD39 catalyzes the rate-limiting degradation step of this immunostimulatory ATP, leading to a
Autor:
Cole Trapnell, Stacey Aggarwal, Yasemin Sancak, Laura Gabrovsek, Shao En Ong, Kerrie B. Collins, Ho-Tak Lau, Lauren M. Saunders, F. Donelson Smith, Danny Suh, John D. Scott
Publikováno v:
J Biol Chem
Compartmentalization of macromolecules is a ubiquitous molecular mechanism that drives numerous cellular functions. The appropriate organization of enzymes in space and time enables the precise transmission and integration of intracellular signals. M
Publikováno v:
2021 IEEE Real-Time Systems Symposium (RTSS).
Autor:
Jingyuan Chen, James H. Anderson, F. Donelson Smith, Joshua Bakita, Sims Hill Osborne, Stephen Tang, Shareef Ahmed
Publikováno v:
RTAS
Simultaneous multithreading (SMT) enables enhanced computing capacity by allowing multiple tasks to execute concurrently on the same computing core. Despite its benefits, its use has been largely eschewed in work on real-time systems due to concerns