First-in-human study demonstrating the safety and clinical efficacy of novel anti-IL-17A monoclonal antibody CJM112 in moderate to severe plaque psoriasis

Autor: J M Rondeau, R Mussmann, R Cebe, Philip Jarvis, Thomas Huber, I Rozenberg, Claudio Calonder, Maher Aassi, Frank Kolbinger, T S Sligh, M Kaul, P Espie, F Di Padova

Publikováno v: Journal of the European Academy of Dermatology and Venereology

Background and objective Anti‐IL‐17A IgG/κ monoclonal antibody CJM112 binds both IL‐17A and IL‐17AF. The purpose of this First‐in‐Human study was to assess CJM112 effects on safety and efficacy in patients with moderate to severe plaque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e0dbd91de959590069150eb7d59e45
https://pubmed.ncbi.nlm.nih.gov/33617042

Detection of Enterobacterial Lipopolysaccharides and Experimental Endotoxemia by Means of an Immunolimulus Assay Using Both SerotypeSpecific and Cross-Reactive Antibodies

Autor: A. Lindberg, S. J. Cryz, Harri Saxen, F. di Padova, Jaana Vuopio-Varkila, Jussi Mertsola, Eric J. Hansen, Alois B. Lang, J. Luk, George H. McCracken

Publikováno v: Saxen, Harri; Vuopio-Varkila, Jaana; Luk, John; Lindberg, Alf; Lang, Alois; Di Padova, Franco; Cryz, Stanley J.; Mertsola, Jussi; Mccracken, George H.; Hansen, Eric J. (1993). Detection of Enterobacterial Lipopolysaccharides and Experimental Endotoxemia by Means of an Immunolimulus Assay Using Both Serotype-Specific and Cross-Reactive Antibodies. Journal of infectious diseases, 168(2), pp. 393-399. The University of Chicago Press 10.1093/infdis/168.2.393
Scopus-Elsevier

The immunolimulus (IML) assay system uses solid-phase endotoxin antibodies to capture lipopolysaccharide (LPS), which is then quantified by a modification of the chromogenic limulus amebocyte lysate (CLAL) method. Monoclonal antibodies (MAbs) reactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3e4275017f38fcc7e406c5ae6fd820
http://doc.rero.ch/record/293951/files/168-2-393.pdf

Coordinate activation of endogenous p38a, β, γ, and δ by inflammatory stimuli

Autor: Richard J. Ulevitch, Hermann Gram, Colleen Fearns, Jiahuai Han, Mauro Zurini, F Di Padova, Lois Kline

Publikováno v: Journal of Leukocyte Biology. 67:705-711

The p38 family of mitogen-activated protein kinases is believed to mediate a variety of leukocyte responses to pro-inflammatory stimuli. There are four members of the p38 family, and although activation of the different members has been studied in tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e49101ac472cfce872e07cce63b65e1e
https://doi.org/10.1002/jlb.67.5.705

Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient mice

Autor: B Ryffel, F Di Padova, M H Schreier, M Le Hir, H P Eugster, V F Quesniaux

Publikováno v: The Journal of Immunology. 158:2126-2133

TNF is implicated in in vitro Ig production, but its role in vivo is not clearly defined. Our previous studies had shown that TNF-LT alpha double-deficient mice have defective IgM and IgG primary Ab responses to the T cell-dependent (TD) Ag SRBC. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdffd84fb40380c0d7051b3fd3d32be1
https://doi.org/10.4049/jimmunol.158.5.2126

Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling

Autor: Mathias Müller, F. Di Padova, Marie Kosco-Vilbois, M. Moore, B Ryffel, Hans-Pietro Eugster, M Le Hir, Horst Bluethmann

Publikováno v: The Journal of Experimental Medicine

Using mice double deficient for tumor necrosis factor (TNF) and lymphotoxin alpha (LT alpha), we demonstrated that TNF and/or LT alpha are necessary for development of a normal splenic microarchitecture and for isotype switch after immunization with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369bac384f05982aee2102628d47078e
http://europepmc.org/articles/PMC2192569