Výsledky vyhledávání

DNA damage induced by cigarette smoke condensate in vitro as assayed by 32P-postlabeling. Comparison with cigarette smoke-associated DNA adduct profiles in vivo

Autor: Erika Randerath, Kurt Randerath, Tracy F. Danna

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 268:139-153

Cigarette smoke induces a multitude of bulky/aromatic DNA adducts in vivo as revealed by 32P-postlabeling assay. The formation of such adducts is thought to involve metabolic activation of aromatic chemicals especially polycyclic aromatic hydrocarbon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20157ec08325b653a2c0f2d03041ef68
https://doi.org/10.1016/0027-5107(92)90091-f

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Bulky adducts detected by 32P-postlabeling in DNA modified by oxidative damage in vitro. Comparison with rat lung I-compounds

Autor: Erika Randerath, Pei-Fang Yang, Tracy F. Danna, William P. Watson, Ranjani Reddy, Kurt Randerath

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 250:135-144

Oxygen free radicals, such as the hydroxyl radical generated by interaction of Fe2+ and H2O2 (Fenton reaction), are produced in mammalian cells as a result of aerobic metabolism and under various pathological conditions and are known to elicit mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afc20c48048cd599724c3b122487dda
https://doi.org/10.1016/0027-5107(91)90169-o

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Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling

Autor: Tracy F. Danna, M. Sambasiva Rao, Ranjani Reddy, Kurt Randerath, Janardan K. Reddy, Erika Randerath

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 247:65-76

The mechanisms of the hepatocarcinogenicity of non-mutagenic peroxisome proliferators, i.e. compounds used as hypolipidemic drugs and industrial plasticizers, are not sufficiently understood. To gain more information on the mechanism of their action,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256cd8802676925bc61adb1fd435279d
https://doi.org/10.1016/0027-5107(91)90034-l

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Enhancement of age-related increases in DNA I-compound levels by calorie restriction: comparison of male B-N and F-344 rats

Autor: Ranjani Reddy, Guo-Dong Zhou, Erika Randerath, Ronald W. Hart, Kurt Randerath, Tracy F. Danna

Publikováno v: Mutation research. 295(1)

Caloric restriction (CR), known to extend median and maximum life spans, improve resistance to carcinogenesis, and significantly retard age-associated degenerative diseases in rodents, was previously reported to modulate levels of indigenous, age-dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e8dceb141b4b67002af42ede9fb70c
https://pubmed.ncbi.nlm.nih.gov/7677927

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Formation of ribonucleotides in DNA modified by oxidative damage in vitro and in vivo. Characterization by 32P-postlabeling

Autor: Anthony E. Crane, Kurt Randerath, Tracy F. Danna, Erika Randerath, William P. Watson, Ranjani Reddy

Publikováno v: Mutation research. 275(3-6)

Oxygen free radicals generated by the interaction of Fe2+ and H2O2 (Fenton reaction) are capable of reacting with DNA bases, which may induce premutagenic and precarcinogenic lesions. Products formed in DNA by such reactions have been characterized a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0178fae73f6b06baa51f94d4be36d34f
https://pubmed.ncbi.nlm.nih.gov/1383776

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Effects of aging and caloric restriction on I-compounds in liver, kidney and white blood cell DNA of male Brown-Norway rats

Autor: Tracy F. Danna, Kurt Randerath, Ranjani Reddy, Erika Randerath, Ronald W. Hart, Angelo Turturro

Publikováno v: Mechanisms of ageing and development. 58(2-3)

Rodent tissues display species-, strain-, sex- and tissue-specific adduct-like DNA modifications termed I-compounds, which increase with age, are modulated by diet and are presumably derived from indigenous metabolic intermediates. We have explored w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c031563955a73afe343107995c1c24
https://pubmed.ncbi.nlm.nih.gov/1875735

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Lack of I-compounds in DNA from a spectrum of Morris hepatomas

Autor: Tracy F. Danna, Erika Randerath, Kurt Randerath

Publikováno v: Carcinogenesis. 11(6)

A partial, progressive loss of I-compounds (age-dependent, putative indigenous DNA modifications) has been observed recently during hepatocarcinogenesis induced in rats by 2,3,7,8-tetrachlorodibenzo-p-dioxin, choline-devoid diet or peroxisome prolife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465888f1755964d576a37f28314f6872
https://pubmed.ncbi.nlm.nih.gov/2347063

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Antibacterial Cotton Blend Nonwovens

Autor: Tyrone L. Vigo, D.V. Parikh, Gary F. Danna

Publikováno v: International Nonwovens Journal. :1558925001OS-01

A new environmentally benign antibacterial agent (magnesium hydroperoxyacetate or MHPA, the reaction product of magnesium acetate tetrahydrate and hydrogen peroxide) was affixed to cotton/polyester webs of varying fiber content (10/90, 20/80 and 30/7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7f8facb68596af1121965667cc505a7
https://doi.org/10.1177/1558925001os-01000310

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