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Akademický článek

Association of CDH1 Germline Variants and Colon Polyp Phenotypes in Patients With Hereditary Diffuse Gastric Cancer

Autor: Monica Passi, Lauren A. Gamble, Sarah G. Samaranayake, Samuel A. Schueler, Bryan F. Curtin, Grace-Ann Fasaye, Cassidy Bowden, Sandeep Gurram, Martha Quezado, Markku Miettinen, Christopher Koh, Theo Heller, Jeremy L. Davis

Publikováno v: Gastro Hep Advances, Vol 2, Iss 2, Pp 244-251 (2023)

Background and Aims: Germline CDH1 variants resulting in E-cadherin loss of function result in an increased risk of diffuse type gastric cancer and lobular type breast cancer. However, the risk of developing other epithelial neoplasms, specifically c

Externí odkaz: https://doaj.org/article/dea145815da64fa1838f6de7915920a3

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Akademický článek

Three-Dimensional (3D) in vitro cell culture protocols to enhance glioblastoma research.

Autor: Janith Wanigasekara, Lara J Carroll, Patrick J Cullen, Brijesh Tiwari, James F Curtin

Publikováno v: PLoS ONE, Vol 18, Iss 2, p e0276248 (2023)

Three-dimensional (3D) cell culture models can help bridge the gap between in vitro cell cultures and in vivo responses by more accurately simulating the natural in vivo environment, shape, tissue stiffness, stressors, gradients and cellular response

Externí odkaz: https://doaj.org/article/16018d74e6ea41678fd2dc3e092dc693

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Akademický článek

Inactivation efficacy of atmospheric air plasma and airborne acoustic ultrasound against bacterial biofilms

Autor: Apurva D. Patange, Jeremy C. Simpson, James F. Curtin, Catherine M. Burgess, P. J. Cullen, Brijesh K. Tiwari

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Biofilms are complex microbial communities that present serious contamination risks to our environment and health. In this study, atmospheric air plasma and airborne acoustic ultrasound technology were applied to inactivate Escherichia coli

Externí odkaz: https://doaj.org/article/f254772cb4d14fde8f0f557f977d2873

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Akademický článek

Structure based prediction of a novel GPR120 antagonist based on pharmacophore screening and molecular dynamics simulations

Autor: Ajay Pal, James F. Curtin, Gemma K. Kinsella

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6050-6063 (2021)

The G-protein coupled receptor, GPR120, has ubiquitous expression and multifaceted roles in modulating metabolic and anti-inflammatory processes. Recent implications of its role in cancer progression have presented GPR120 as an attractive oncogenic d

Externí odkaz: https://doaj.org/article/fcf19c2399204e4fa659764299d2f8fb

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Akademický článek

Hyperbranched Poly(β-amino ester)s (HPAEs) Structure Optimisation for Enhanced Gene Delivery: Non-Ideal Termination Elimination

Autor: Yinghao Li, Zhonglei He, Jing Lyu, Xianqing Wang, Bei Qiu, Irene Lara-Sáez, Jing Zhang, Ming Zeng, Qian Xu, Sigen A, James F. Curtin, Wenxin Wang

Publikováno v: Nanomaterials, Vol 12, Iss 21, p 3892 (2022)

Many polymeric gene delivery nano-vectors with hyperbranched structures have been demonstrated to be superior to their linear counterparts. The higher delivery efficacy is commonly attributed to the abundant terminal groups of branched polymers, whic

Externí odkaz: https://doaj.org/article/80f25149837d4d858c773eed09617a31

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