Výsledky vyhledávání

Modified pyridine-2,6-dicarboxylate acid ligands for sensitization of near-infrared luminescence from lanthanide ions (Ln3+ = Pr3+, Nd3+, Gd3+, Dy3+, Er3+)

Autor: Martin C. Grossel, George F. S. Whitehead, Paul E. Critchley, Richard J. Curry, B. N. Murdin, Michael R. George, Andrew J. Bailey, F. Cuda

Publikováno v: George, M, Critchley, P, Whitehead, G, Bailey, A, Cuda, F, Murdin, B, Grossel, M & Curry, R 2021, ' Modified Pyridine-2,6-dicarboxylate Acid Ligands for Sensitization of Near-Infrared Luminescence from Lanthanide Ions (Ln3+ = Pr3+, Nd3+, Gd3+, Dy3+, Er3+) ', Journal of Luminescence, vol. 230, 117715 . https://doi.org/10.1016/j.jlumin.2020.117715

A detailed study of the ability of pyridine-2,6-dicarboxylic acid (1) and its 4-mono- and 3,4,5-tri-substituted analogues to sensitize emission from Pr3+, Nd3+, Gd3+, Dy3+ and Er3+ is presented. Sensitization of Ln3+ emission was demonstrated via the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35973d6edbd767978da5bc27bcc54a8
https://eprints.soton.ac.uk/444842/

Zobrazit plný text záznamu

Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS

Autor: Dharyl C. Wilson, Anqi Chen, A.S. Bienemann, Mark E. Light, F. Cuda, Daniel J. Asby, Ali Tavassoli, M. G. Radigois, Christina L. L. Chai, David C. Harrowven

Publikováno v: Asby, D J, Radigois, M G, Wilson, D C, Cuda, F, Chai, C L L, Chen, A, Bienemann, A S, Light, M E, Harrowven, D C & Tavassoli, A 2016, ' Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS ', Organic and Biomolecular Chemistry, vol. 14, no. 39, pp. 9322-9330 . https://doi.org/10.1039/c6ob01591c

Elevation of reactive oxygen species (ROS) is both a consequence and driver of the upregulated metabolism and proliferation of transformed cells. The resulting increase in oxidative stress is postulated to saturate the cellular antioxidant machinery,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a7929b1bbcf29f83aa92cc8e525292
https://doi.org/10.1039/c6ob01591c

Zobrazit plný text záznamu

Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance

Autor: Kamaljit Kaur, Ali Tavassoli, Hoda Soleymani Abyaneh, Amir Soleimani, Afsaneh Lavasanifar, Rania Soudy, F. Cuda, Mohammad Reza Vakili

Publikováno v: Pharmaceutics
Pharmaceutics, Vol 10, Iss 4, p 196 (2018)
Volume 10
Issue 4

Hypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c156311f91a6f622bae70656b9cb8a
http://europepmc.org/articles/PMC6320993

Zobrazit plný text záznamu

A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

Autor: Elena Miranda, Ali Tavassoli, Paul A. Townsend, Keith R. Fox, Suzanne A. Eccles, William Court, Franciane Hoakwie, F. Cuda, Abigail L. Male, Ida Karin Nordgren, Graham Packham, Charlotte E. Lawrence

Publikováno v: Journal of the American Chemical Society

Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors. Here we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adff389052d2ab392dcfd8359c42daed
https://doi.org/10.1021/ja402993u

Zobrazit plný text záznamu

Targeting Tumour Proliferation with a Small-Molecule Inhibitor of AICAR Transformylase Homodimerization

Autor: Charles N. Birts, Stephen J. Benkovic, Ali Tavassoli, Ian B. Spurr, Jeremy P. Blaydes, F. Cuda

Publikováno v: ChemBioChem. 13:1628-1634

Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) is a bifunctional homodimeric enzyme that catalyzes the last two steps of de novo purine biosynthesis. Homodimerization of ATIC, a protein-protein in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::530b6b87baf7c4a3344202f39517a00b
https://doi.org/10.1002/cbic.201200279

Zobrazit plný text záznamu

AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization

Autor: Franchesca D. Houghton, Felino R. Cagampang, Daniel J. Asby, Maxime Beyaert, Ali Tavassoli, F. Cuda

Publikováno v: Chemistrybiology. 22(7)

Summary5-Aminoimidazole-4-carboxamide ribonucleotide (known as ZMP) is a metabolite produced in de novo purine biosynthesis and histidine biosynthesis, but only utilized in the cell by a homodimeric bifunctional enzyme (called ATIC) that catalyzes th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c840e02c7b27fba0c00e0c1994feb98a
https://pubmed.ncbi.nlm.nih.gov/26144885

Zobrazit plný text záznamu

HIF-1 promotes the expression of its α-subunit via an epigenetically regulated transactivation loop

Autor: Elena Miranda, Franciane Hoakwie, Daniel J. Asby, Ali Tavassoli, F. Cuda

Publikováno v: Molecular bioSystems. 10(10)

Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1α/HIF-1β protein–protein interaction to show the presence of an epigenetically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092e514b805c94484220eed5847254da
https://pubmed.ncbi.nlm.nih.gov/25091694

Zobrazit plný text záznamu

Biodegradable poly(α-hydroxy ester) blended microspheres as suitable carriers for retinal pigment epithelium cell transplantation

Autor: A. J. Treharne, L. S. Backholer, F. Cuda, Heather Thomson, Andrew J. Lotery, M. C. Grossel

Publikováno v: Journal of biomedical materials research. Part A. 95(4)

Five blends of poly(L-lactic acid) (PLLA) with poly(D,L-lactic-co-glycolic acid) (PLGA) were used to prepare microcarriers by a solvent evaporation technique. Microcarriers were evaluated as suitable scaffolds to facilitate retinal pigment epithelium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aef30da052641b91fe7623da78a3795
https://pubmed.ncbi.nlm.nih.gov/20939049

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání