Zobrazeno 1 - 10
of 2 177
pro vyhledávání: '"F. Coskun"'
Autor:
Thomas Hu, Mayar Allam, Shuangyi Cai, Walter Henderson, Brian Yueh, Aybuke Garipcan, Anton V. Ievlev, Maryam Afkarian, Semir Beyaz, Ahmet F. Coskun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Metabolic reprogramming in cancer and immune cells occurs to support their increasing energy needs in biological tissues. Here we propose Single Cell Spatially resolved Metabolic (scSpaMet) framework for joint protein-metabolite profiling of
Externí odkaz:
https://doaj.org/article/005c3c264bfd4983a199d821ea1bd797
Autor:
Mythreye Venkatesan, Nicholas Zhang, Benoit Marteau, Yukina Yajima, Nerea Ortiz De Zarate Garcia, Zhou Fang, Thomas Hu, Shuangyi Cai, Adam Ford, Harrison Olszewski, Andrew Borst, Ahmet F. Coskun
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Organelles play important roles in human health and disease, such as maintaining homeostasis, regulating growth and aging, and generating energy. Organelle diversity in cells not only exists between cell types but also between individual cel
Externí odkaz:
https://doaj.org/article/9bbd5f5e6dc14ed5a9612c11b696e296
Autor:
Dan Li, Zhou Fang, Qiang Shi, Nicholas Zhang, Binsheng Gong, Weida Tong, Ahmet F. Coskun, Joshua Xu
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 7, Pp 691-693 (2023)
Externí odkaz:
https://doaj.org/article/24c6f24a66074ea08ab225136cf50050
Autor:
Mayar Allam, Thomas Hu, Jeongjin Lee, Jeffrey Aldrich, Sunil S. Badve, Yesim Gökmen-Polar, Manali Bhave, Suresh S. Ramalingam, Frank Schneider, Ahmet F. Coskun
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-21 (2022)
Abstract The Immunoscore is a method to quantify the immune cell infiltration within cancers to predict the disease prognosis. Previous immune profiling approaches relied on limited immune markers to establish patients’ tumor immunity. However, imm
Externí odkaz:
https://doaj.org/article/9e5070068683451ebbd1a83b5eb66b7b
Publikováno v:
IEEE Access, Vol 10, Pp 109814-109849 (2022)
Increasing number of devices connected to the networks, applications and demands of new generation wireless communications cause very high energy consumption resulting in large amount of carbon emission. Thus, energy harvesting solutions together wit
Externí odkaz:
https://doaj.org/article/9e50d54be7cf47d5b33aa24b60031d0b
Autor:
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Frank Schneider, Suresh S. Ramalingam, Shi-Yong Sun, Ahmet F. Coskun
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104980- (2022)
Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays.
Externí odkaz:
https://doaj.org/article/2973f78274a64a138c9d983aadb5dd2c
Autor:
Xavier Rovira-Clavé, Sizun Jiang, Yunhao Bai, Bokai Zhu, Graham Barlow, Salil Bhate, Ahmet F. Coskun, Guojun Han, Chin-Min Kimmy Ho, Chuck Hitzman, Shih-Yu Chen, Felice-Alessio Bava, Garry P. Nolan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Multiplexed ion beam imaging can provide subcellular localisation information but with limited resolution. Here the authors report an ion beam imaging method with nanoscale resolution which they use to assess the subcellular distribution of cisplatin
Externí odkaz:
https://doaj.org/article/18ad42beb0ae47dfab30d767ad938893
Autor:
Mayar Allam, Thomas Hu, Shuangyi Cai, Krishnan Laxminarayanan, Robert B. Hughley, Ahmet F. Coskun
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Allam, Hu, et al. present SpatialViz, a suite of algorithms to explore spatial relationships in multiplexed tissue images by visualizing and quantifying single-cell granularity and anatomical complexity in diverse multiplexed tissue imaging data. The
Externí odkaz:
https://doaj.org/article/58ad3fe1ce344e29a65c37672e679c0a
Autor:
Ahmet F. Coskun, Guojun Han, Shambavi Ganesh, Shih-Yu Chen, Xavier Rovira Clavé, Stefan Harmsen, Sizun Jiang, Christian M. Schürch, Yunhao Bai, Chuck Hitzman, Garry P. Nolan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Secondary ion beam mass spectrometry (SIMS) is a method to obtain a chemical snapshot of biological tissue, but the spatial resolution is low. Here, the authors develop a computational and technology pipeline to localise a chemical signal in SIMS in
Externí odkaz:
https://doaj.org/article/882ce2bc30f347449f3e0769771cb2d7
Autor:
Shivem B. Shah, Christopher R. Carlson, Kristine Lai, Zhe Zhong, Grazia Marsico, Katherine M. Lee, Nicole E. Félix Vélez, Elisabeth B. Abeles, Mayar Allam, Thomas Hu, Lauren D. Walter, Karen E. Martin, Khanjan Gandhi, Scott D. Butler, Rishi Puri, Angela L. McCleary-Wheeler, Wayne Tam, Olivier Elemento, Katsuyoshi Takata, Christian Steidl, David W. Scott, Lorena Fontan, Hideki Ueno, Benjamin D. Cosgrove, Giorgio Inghirami, Andrés J. García, Ahmet F. Coskun, Jean L. Koff, Ari Melnick, Ankur Singh
Publikováno v:
Nature Materials. 22:511-523
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::437c365c91fd56ca70ff4d85310517bf
https://doi.org/10.1038/s41563-023-01495-3
https://doi.org/10.1038/s41563-023-01495-3