Cytoprotective effect of 1-nitro-2-phenylethane in mice pancreatic acinar cells subjected to taurocholate: Putative role of guanylyl cyclase-derived 8-nitro-cyclic-GMP

Autor: Saad Lahlou, Francisco J.B. Lima, Pedro Jorge Caldas Magalhães, F. Cosker

Publikováno v: Biochemical Pharmacology. 91:191-201

The nitroderivative 1-nitro-2-phenylethane (NPE) was recently described as a compound possessing heme-dependent soluble guanylyl cyclase (sGC) stimulating properties in vascular smooth muscle cells. In this study, we tested such pharmacological prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb0f2c2d4f30dc5abf8c39cb9c7c951
https://doi.org/10.1016/j.bcp.2014.07.030

(-)-α-Bisabolol inhibits preferentially electromechanical coupling on rat isolated arteries

Autor: Pjc Magalhães, Alfredo Augusto Vasconcelos-Silva, Saad Lahlou, Walter B.S. Freire, R. J. B. de Siqueira, Helder Veras Ribeiro-Filho, R.S. Freire, F. Cosker, M.A. Soares

Publikováno v: Vascular pharmacology. 63(1)

Previous findings enable us to hypothesize that (-)-α-bisabolol acts as inhibitor of voltage-dependent Ca(2+) channels in smooth muscle. The current study was aimed at consolidating such hypothesis through the recording of isometric tension, measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce92be61ebb831a5beccf9ef9cb3cb9d
https://pubmed.ncbi.nlm.nih.gov/25128618

Myorelaxant effects of methyl cinnamate, the major constituent of the essential oil of Ocimum micranthum, on smooth muscle of the gastrointestinal tract of rats

Autor: F. Cosker, Francisco J.B. Lima, Pjc Magalhães, HV Ribeiro-Filho, MH Souza, Alfredo Augusto Vasconcelos-Silva, M.A. Soares

Publikováno v: Planta Medica. 79

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1936ca5bda7fc4db67e10b321eaa9ecd
https://doi.org/10.1055/s-0033-1352063

Vasorelaxation induced by (-)-α-Bisabolol in rat aorta is preferential to voltage-operated contractile pathways

Autor: CR Roque, Alfredo Augusto Vasconcelos-Silva, F. Cosker, Pjc Magalhães, PA Fonseca-Magalhães, Saad Lahlou, Wbs Freire, R.S. Freire, Rjb de Siqueira, LC Ferreira

Publikováno v: Planta Medica. 78

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc9b3fc0a9271b4eeabd8840583737e8
https://doi.org/10.1055/s-0032-1320475

Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner

Autor: Karoline S. Aragão, Carlos W. S. Wanderley, Fernando Q. Cunha, Camila Meireles de Souza Silva, Raimundo C. Palheta-Junior, Ronaldo A. Ribeiro, Camila Fernandes, D.F.C. Morelo, F. Cosker, Gerly Anne de Castro Brito, Deysi Viviana Tenazoa Wong, Alexandre Havt, Rafael Matos Ximenes, Roberto C. P. Lima-Júnior

Publikováno v: Europe PubMed Central
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Local tissue reactions provoked by Bothrops venoms are characterized by edema, hemorrhage, pain, and inflammation; however, the mechanisms of tissue damage vary depending upon the species of snake. Here, we investigated the mechanisms involved in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6289a3eb610e4ce58aa6551b07eb81a
http://europepmc.org/abstract/med/25127849