Zobrazeno 1 - 10
of 128
pro vyhledávání: '"F. Brad Johnson"'
Autor:
Elisia D. Tichy, Ji-Hyung Lee, Grant Li, Katrina N. Estep, F. Brad Johnson, Foteini Mourkioti
Publikováno v:
npj Microgravity, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity. Spaceflight elongates human telomeres in peripheral blood, which shorten upon return to Earth and approach baseline levels during postflight recovery. A
Externí odkaz:
https://doaj.org/article/49296aaceaad41838d28e1fc4c254dfa
Autor:
Young-Jun Choi, Melissa S. Kim, Joshua H. Rhoades, Nicolette M. Johnson, Corbett T. Berry, Sarah Root, Qijun Chen, Yuhua Tian, Rafael J. Fernandez, III, Zvi Cramer, Stephanie Adams-Tzivelekidis, Ning Li, F. Brad Johnson, Christopher J. Lengner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 451-472 (2023)
Background & Aims: Dyskeratosis congenita (DC) is a telomere biology disorder caused primarily by mutations in the DKC1 gene. Patients with DC and related telomeropathies resulting from premature telomere dysfunction experience multiorgan failure. In
Externí odkaz:
https://doaj.org/article/097aee7b209740a1bf70038743eb0b74
Autor:
Yang Mei, Zhong Deng, Olga Vladimirova, Nitish Gulve, F. Brad Johnson, William C. Drosopoulos, Carl L. Schildkraut, Paul M. Lieberman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Telomere dysfunction causes chromosomal instability which is associated with many cancers and age-related diseases. The non-coding telomeric repeat-containing RNA (TERRA) forms a structural and regulatory component of the telomere that is im
Externí odkaz:
https://doaj.org/article/66afc9aff8e74ec3a03afa244b0f1666
Autor:
Elisia D. Tichy, David K. Sidibe, Matthew T. Tierney, Michael J. Stec, Maryam Sharifi-Sanjani, Harish Hosalkar, Scott Mubarak, F. Brad Johnson, Alessandra Sacco, Foteini Mourkioti
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1328-1341 (2017)
Muscle stem cells (MuSCs) contribute to muscle regeneration following injury. In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction. While telomere attrition may contribute to aberrant stem cell functions, m
Externí odkaz:
https://doaj.org/article/53d32f4122614c7e89b36de0894eaa3d
Autor:
Ting-Lin B. Yang, Qijun Chen, Jennifer T. Deng, Geetha Jagannathan, John W. Tobias, David C. Schultz, Shan Wang, Christopher J. Lengner, Anil K. Rustgi, John P. Lynch, F. Brad Johnson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Mice lacking telomerase provide a model to study pathogenesis caused by critical telomere shortening. Here, the authors provide evidence that telomere shortening causes downregulation of Wnt signalling in intestinal crypts and that defects can be par
Externí odkaz:
https://doaj.org/article/84db73bd9d44488982b5724af9d64be0
Autor:
Qiujing Yu, Yuliya V. Katlinskaya, Christopher J. Carbone, Bin Zhao, Kanstantsin V. Katlinski, Hui Zheng, Manti Guha, Ning Li, Qijun Chen, Ting Yang, Christopher J. Lengner, Roger A. Greenberg, F. Brad Johnson, Serge Y. Fuchs
Publikováno v:
Cell Reports, Vol 11, Iss 5, Pp 785-797 (2015)
Expression of type I interferons (IFNs) can be induced by DNA-damaging agents, but the mechanisms and significance of this regulation are not completely understood. We found that the transcription factor IRF3, activated in an ATM-IKKα/β-dependent m
Externí odkaz:
https://doaj.org/article/40e4f013559c414cb26eb222a100c6da
Autor:
Nilesh Chitnis, Peter M. Clark, Malek Kamoun, Catherine Stolle, F. Brad Johnson, Dimitri S. Monos
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
We describe a novel functional role for the HLA-B locus mediated by its intron-encoded microRNA (miRNA), miR-6891-5p. We show that in vitro inhibition of miR-6891-5p impacts the expression of nearly 200 transcripts within the B-lymphoblastoid cell li
Externí odkaz:
https://doaj.org/article/9702f9ef2c024e5ca89021a925ae02e0
Autor:
Carl H. June, Michael C. Milone, Michael Kalos, Yangbing Zhao, Chrystal M. Paulos, F. Brad Johnson, Jesse M. Platt, Laurence J.N. Cooper, Sonny Ang, Avery D. Posey, Shannon E. McGettigan, Sonia Guedan, Omkar U. Kawalekar, John Scholler, Shinichiro Motohashi, Carmine Carpenito, Maria Ciocca Basil, Jihyun Lee, Matthew J. Frigault
This study compared second-generation chimeric antigen receptors (CAR) encoding signaling domains composed of CD28, ICOS, and 4-1BB (TNFRSF9). Here, we report that certain CARs endow T cells with the ability to undergo long-term autonomous proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f3bff5e6b4e8eccb2b0a30c2a678d8
https://doi.org/10.1158/2326-6066.c.6548833.v1
https://doi.org/10.1158/2326-6066.c.6548833.v1
Autor:
Carl H. June, Michael C. Milone, Michael Kalos, Yangbing Zhao, Chrystal M. Paulos, F. Brad Johnson, Jesse M. Platt, Laurence J.N. Cooper, Sonny Ang, Avery D. Posey, Shannon E. McGettigan, Sonia Guedan, Omkar U. Kawalekar, John Scholler, Shinichiro Motohashi, Carmine Carpenito, Maria Ciocca Basil, Jihyun Lee, Matthew J. Frigault
Table S1: Expression of c-Met and Mesothelin mRNA in activated CD4 T Cells. Table S2: Genes upregulated in CD4+ T cells of healthy human adults expressing c-Met IgG4 continuous CAR or CD19 CD8α non-continuous CAR on day 11. Table S3: Genes downregul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797fb8c4889476e2f5c1dda3bbd54ca6
https://doi.org/10.1158/2326-6066.22538623
https://doi.org/10.1158/2326-6066.22538623
Autor:
Robert H. Vonderheide, David L. Porter, F. Brad Johnson, Noelle V. Frey, Barbara A. Vance, Theresa A. Colligon, Kunal P. Patel, Ran Reshef, Jasmine S. Smith, Gregory L. Beatty
Supplementary Data from Functional Unresponsiveness and Replicative Senescence of Myeloid Leukemia Antigen–specific CD8+ T Cells After Allogeneic Stem Cell Transplantation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201ad8c9a5d171de54e7f98ffed3ec5a
https://doi.org/10.1158/1078-0432.22440825.v1
https://doi.org/10.1158/1078-0432.22440825.v1