Zobrazeno 1 - 10
of 59
pro vyhledávání: '"F. Bisset"'
Publikováno v:
Tetrahedron. 53:13383-13396
Several novel antifolates, derivatives of 2-desamino-2-methyl- N 10 -propargyl-5,8-dideazafolic acid, were synthesised as inhibitors of thymidylate synthase (TS) and antitumour agents. This was accomplished by first developing routes to the key inter
Publikováno v:
Douleur et Analgésie. 10:33-43
Les auteurs ont etudie en retrospectif les resultats obtenus apres une prise en charge reeducative de 105 patients lombosciatalgiques chroniques. Cette prise en charge a ete multidisciplinaire, c'est-a-dire ne s'est pas limitee a la simple dimension
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:631-636
Tetrazole carboxylic acid bioisosteres of γ-linked dipeptide derivatives of 2-desamino-2-methyl-N 10 -propargyl-5,8-dideazafolic acid (ICI 198583), a folate-based inhibitor of thymidylate synthase (TS), were synthesised by multistep routes starting
Publikováno v:
Journal of Medicinal Chemistry. 39:73-85
The syntheses of γ-linked l-d, d-d, and d-l dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) are described. The general methodology for the synthesis of these molecules involved the preparation of the dipep
Publikováno v:
Synthetic Communications. 25:947-958
Utilisation of γ-allyl ester protection of glutamates provides a convenient route to the synthesis of Z-Glu-OBut, Tr-Glu-OBut and (Boc)2-Glu-OBut.
Autor:
Daphne Russell, Ann F Bisset
Publikováno v:
BMJ. 308:1129-1132
Objective: To see whether there is a relation between grommet insertion operation and tonsillectomy rates, otolaryngology services, and deprivation scores in Scotland. Design: Analysis of routine 1990 NHS data on grommet insertions and tonsillectomie
Publikováno v:
Journal of Fluorine Chemistry. 60:31-38
A synthesis of a tetrafluoro derivative of the quinazoline antifolate 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid is described. 2-Desamino-2-methyl-N10-propargyl-2′,3′,5′,6′-tetrafluoro-5,8-dideazafolic acid (1) has been made in f
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 26
Utilisation of γ-allyl ester protection of glutamates provides a convenient route to the synthesis of Z-Glu-OBut, Tr-Glu-OBut and (Boc)2-Glu-OBut.
Publikováno v:
ChemInform. 27
The syntheses of γ-linked l-d, d-d, and d-l dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) are described. The general methodology for the synthesis of these molecules involved the preparation of the dipep