Zobrazeno 1 - 10
of 108
pro vyhledávání: '"F. Bellon"'
Autor:
Alexander M. Taylor, Chris Bailey, Lisa D. Belmont, Robert Campbell, Nico Cantone, Alexandre Côté, Terry D. Crawford, Richard Cummings, Kevin DeMent, Martin Duplessis, Megan Flynn, Andrew C. Good, Hon-Ren Huang, Shivangi Joshi, Yves Leblanc, Jeremy Murray, Christopher G. Nasveschuk, Adrianne Neiss, Florence Poy, F. Anthony Romero, Peter Sandy, Yong Tang, Vickie Tsui, Laura Zawadzke, Robert J. Sims, James E. Audia, Steven F. Bellon, Steven R. Magnuson, Brian K. Albrecht, Andrea G. Cochran
Publikováno v:
Journal of medicinal chemistry. 65(16)
Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small molecules that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery efforts. Highly potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e88d18fd974b18b10231a436e2238a9
https://pubmed.ncbi.nlm.nih.gov/35930799
https://pubmed.ncbi.nlm.nih.gov/35930799
Autor:
Gabriel J. Sandoval, Katharine Feldman, Sal Topal, Ammar Adam, Hsin-Jung Wu, Darshan Sappal, Luis M. Soares, David L. Lahr, Lan Xu, Rishi G. Vaswani, Jordana Muwanguzi, Liyue Huang, Jessica Piel, Mike Collins, Ho Man Chan, Michael J. Thomenius, Steven F. Bellon, Ryan G. Kruger, Carl P. Decicco, Richard C. Centore, Martin Hentemann
Publikováno v:
Cancer Research. 82:LB190-LB190
SPI1 (PU.1) is an ETS family transcription factor that plays a critical role in hematopoietic development and differentiation. Regulation of SPI1 expression has also been implicated in Acute Myeloid Leukemia (AML) oncogenesis, though its mechanism is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::275371575ca144b436a9541a469cc338
https://doi.org/10.1158/1538-7445.am2022-lb190
https://doi.org/10.1158/1538-7445.am2022-lb190
Autor:
Zaccaroni A., Andreini R., Silvi M., Charrier I., Mayer F- Bellon H., Adam O., Saloma A., Gleonnec F., Carpentier F-G6, Jung J-L6
Contaminants monitoring in wild, large cetaceans may be performed using internal organs of stranded animals. Although extremely valuable, data obtained from dead animals can be biased by poor health conditions, modifying the concentrations of polluta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4094::67cc9438da8514b4029e073f56a79d76
http://hdl.handle.net/11585/744043
http://hdl.handle.net/11585/744043
Akademický článek
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Akademický článek
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Autor:
Srividya Balasubramanian, Robert K. Campbell, Patrick Trojer, Christina O. Lee, Jon R. Wilson, Emmanuel Normant, Les A. Dakin, Martin Duplessis, Brian K. Albrecht, Jean-Christophe Harmange, Rishi G. Vaswani, James E. Audia, Priyadarshini Iyer, Andrew Simon Cook, Neil Justin, Steven J. Gamblin, Nico Cantone, Andrew C. Good, Feng Zhao, Richard T. Cummings, Steven F. Bellon, Christopher G. Nasveschuk, Shuyang Chen, Ying Zhang, Victor S. Gehling
Publikováno v:
Journal of Medicinal Chemistry. 59:9928-9941
Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of PRC2 function correlates with certain malignancies and poor prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b439dd2f817b39a50f28ca2f51086f0
https://doi.org/10.1021/acs.jmedchem.6b01315
https://doi.org/10.1021/acs.jmedchem.6b01315
Autor:
Karen Rex, Douglas A. Whittington, David Bauer, Steven F. Bellon, Jean-Christophe Harmange, Martin A. Broome, Alessandro Boezio, Christiane Boezio, Karina R. Vaida, Deborah Choquette, Isabelle Dussault, Katrina W. Copeland, Emily A. Peterson, Yohannes Teffera, Roman Shimanovich, Brian K. Albrecht, Richard T. Lewis, Michele Potashman, Jingzhou Liu, Julia Lohman, Angela Coxon, Min-Hwa Jasmine Lin, Satoko Hirai
Publikováno v:
Journal of Medicinal Chemistry. 59:2328-2342
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16401f5e9358f2456fce2725cd044c7
https://doi.org/10.1021/acs.jmedchem.5b01716
https://doi.org/10.1021/acs.jmedchem.5b01716
Autor:
David Powers, Katja Labitzke, Mark J. Rose, Kristin L. Andrews, Richard Kendall, Kenneth R. Dellamaggiore, Shon Booker, Peter Jaeckel, Silvia Materna-Reichelt, Mark H. Norman, Young-Ah Chung, Holger Beckmann, Paul L. Shaffer, Pedro J. Beltran, Hao Chen, Alexander M. Long, Petia Mitchell, Adrian L. Smith, Jennifer Dao, J. Russell Lipford, Noel D'angelo, Steven F. Bellon, Michelle Wu
Publikováno v:
Journal of Medicinal Chemistry. 58:1426-1441
The structure-based design and optimization of a novel series of selective PERK inhibitors are described resulting in the identification of 44 as a potent, highly selective, and orally active tool compound suitable for PERK pathway biology exploratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906c5b60a94b9bc681eaaf3c8dfd6af5
https://doi.org/10.1021/jm5017494
https://doi.org/10.1021/jm5017494
Akademický článek
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Autor:
K. N. Usachev, M. D. Kudryavtsev, D. Rames, N. L. Yavorovskaya, F. Bellon, J. Perdriat, D. G. Gryazin
Publikováno v:
Gyroscopy and Navigation. 4:233-237
The paper describes the measurement procedures used to estimate the parameters of a C40-ST-09 Actidyn Systemes centrifuge by independent external devices. A specific feature of the proposed procedures is that angular errors in compensation for the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a305b2bfde78a7aad45749688c5e96
https://doi.org/10.1134/s2075108713040068
https://doi.org/10.1134/s2075108713040068