Zobrazeno 1 - 10
of 295
pro vyhledávání: '"F. Bear"'
Autor:
James J. Fink, Nathaniel Delaney-Busch, Ryan Dawes, Evanthia Nanou, Christopher Folts, Karthiayani Harikrishnan, Chris Hempel, Hansini Upadhyay, Trinh Nguyen, Himali Shroff, David Stoppel, Steven J. Ryan, Jane Jacques, Jennifer Grooms, Elizabeth Berry-Kravis, Mark F. Bear, Luis A. Williams, David Gerber, Mark Bunnage, Brinley Furey, Graham T. Dempsey
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by hypermethylation of expanded CGG repeats (>200) in the FMR1 gene leading to gene silencing and loss of Fragile X Messenger Ribonucleoprotein (FMRP) expression. FMRP plays im
Externí odkaz:
https://doaj.org/article/4c3520c6a9254e29bb6412e3a3c39efa
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Amblyopia is a common visual impairment that develops during the early years of postnatal life. It emerges as a sequela to eye misalignment, an imbalanced refractive state, or obstruction to form vision. All of these conditions prevent normal vision
Externí odkaz:
https://doaj.org/article/08bc504da2d349d9b601d95fcab6b80c
Indispensable depuis plus de 20 ans, l'ouvrage Neurosciences, à la découverte du cerveau est la référence incontestée pour l'initiation et la formation aux sciences du cerveau. Cette 4e édition met en lumière des avancées majeures si bien qu'
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2022)
Stimulus-selective response plasticity (SRP) is a robust and lasting modification of primary visual cortex (V1) that occurs in response to exposure to novel visual stimuli. It is readily observed as a pronounced increase in the magnitude of visual ev
Externí odkaz:
https://doaj.org/article/b95e678efaa245f7952dabc12755cde1
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate
Externí odkaz:
https://doaj.org/article/d876a8e8eb874f5ea370bbe486d1786b
Publikováno v:
eLife, Vol 10 (2021)
Monocular deprivation early in development causes amblyopia, a severe visual impairment. Prognosis is poor if therapy is initiated after an early critical period. However, clinical observations have shown that recovery from amblyopia can occur later
Externí odkaz:
https://doaj.org/article/f35720d382314c868ccdd3503f5c3c57
Publikováno v:
Current opinion in ophthalmology. 33(6)
We examine the development of amblyopia and the effectiveness of conventional and emerging therapies through the lens of the Bienenstock, Cooper, and Munro (BCM) theory of synaptic modification.The BCM theory posits metaplastic adjustment in the thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a83ba94417e31b1ce86d6df9c5a0ad
https://pubmed.ncbi.nlm.nih.gov/36094025
https://pubmed.ncbi.nlm.nih.gov/36094025
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2020)
Daily exposure of awake mice to a phase-reversing visual grating stimulus leads to enhancement of the visual-evoked potential (VEP) in layer 4 of the primary visual cortex (V1). This stimulus-selective response potentiation (SRP) resembles and shares
Externí odkaz:
https://doaj.org/article/aba751e1c6d54e67980de9fc9bdae0b7
Autor:
Mark F. Bear, Sam F. Cooke, Karl Peter Giese, Bong-Kiun Kaang, Mary B. Kennedy, Ji-il Kim, Richard G. M. Morris, Pojeong Park
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Shortly before he died in October 2017, John Lisman submitted an invited review to Molecular Brain on ‘Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ)’. John had no opportunity to read the referees’ comments,
Externí odkaz:
https://doaj.org/article/99a1e4f246f645e781b82540df3836dc
Autor:
Elizabeth Berry-Kravis, Randi Hagerman, Jeannie Visootsak, Dejan Budimirovic, Walter E. Kaufmann, Maryann Cherubini, Peter Zarevics, Karen Walton-Bowen, Paul Wang, Mark F. Bear, Randall L. Carpenter
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 9, Iss 1, Pp 1-18 (2017)
Abstract Background Arbaclofen improved multiple abnormal phenotypes in animal models of fragile X syndrome (FXS) and showed promising results in a phase 2 clinical study. The objective of the study is to determine safety and efficacy of arbaclofen f
Externí odkaz:
https://doaj.org/article/1600842ad64c4a2f93f317a6e4ba061b