Výsledky vyhledávání - "F. B. F. Law"

Abstract P6-08-13: Personalized and cost-effective detection of copy number variants by molecular-barcode next-generation sequencing and long-read nanopore sequencing

Autor: Ava Kwong, Chun H Au, Dona N. Ho, Jiawei Chen, Elaine Yl Wong, Edmond Sk Ma, Cecilia Ys Ho, Tsun Leung Chan, Vivian Y. Shin, Isabella Cheuk, F. B. F. Law, Hextan Ys Ngan, Yvonne Chung

Publikováno v: Cancer Research. 80:P6-08

Background: Germline copy number variants (CNV) of hereditary breast and ovarian cancer genes are a known class of clinically significant mutations. However, failure to detect CNV is a known limitation of Sanger sequencing and conventional amplicon n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27d10bccfd658936eb203ae330f3583b
https://doi.org/10.1158/1538-7445.sabcs19-p6-08-13

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Abstract P2-07-03: High-throughput germline mutation screening for hereditary breast cancer in southern Chinese patients by massively parallel DNA sequencing

Autor: Dona N. Ho, BK Ip, AT Wong, Esk Ma, Tsun Leung Chan, F. B. F. Law, Chun H Au, Vivian Y. Shin, Ava Kwong

Publikováno v: Cancer Research. 73:P2-07

Introduction: Breast cancer is the most common malignancy and 3rd leading cause of deaths among the female population in Hong Kong. Since the establishment of The Hong Kong Hereditary Breast Cancer Family Registry in 2007, 1344 patients with breast a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bf4c85ba86da8ff7f541f536a09d7d8
https://doi.org/10.1158/0008-5472.sabcs13-p2-07-03

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Detection of KRAS mutations in colorectal cancer by high-resolution melting analysis

Autor: Wayne Chan, Edmond S. K. Ma, C. L. P. Wong, F. B. F. Law, D. Siu

Publikováno v: Journal of Clinical Pathology. 62:886-891

Aims:Mutation of the KRAS gene predicts the clinical response to the monoclonal antibody cetuximab in patients with advanced colorectal cancer (CRC). This study aimed to perform KRAS mutation detection on formalin-fixed paraffin-embedded (FFPE) tumou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59fd656cfc0fcf96b6df01b0b38856a
https://doi.org/10.1136/jcp.2008.063677

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Novel BRCA1 and BRCA2 genomic rearrangements in Southern Chinese breast/ovarian cancer patients

Autor: Hn N. Wong, Dee W. West, Anna Wa, Ava Kwong, James M. Ford, Enders K.O. Ng, F. B. F. Law, Chris L. P. Wong, Edmond S. K. Ma, Allison W. Kurian

Publikováno v: Breast Cancer Research and Treatment

To the Editor, Breast cancer is the most frequently occurring malignancy in not only Western but also Asian women. Germline mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, are found in a significant proportion of patients affect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1e74bc0131fcdd6e733ffb980d6a59
http://europepmc.org/articles/PMC3511694

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High-resolution melting analysis for rapid screening of BRCA2 founder mutations in Southern Chinese breast cancer patients

Autor: Vivian Chan, F. B. F. Law, H Wong, Allison W. Kurian, M. T. Cheung, M. Y. To, Ava Kwong, James M. Ford, Enders K.O. Ng, Dee W. West, L. P. Wong, Edmond S. K. Ma

Publikováno v: Breast Cancer Research and Treatment. 122:605-607

Identification of founder mutations in various ethnic groups is important to improve genetic screening and cancer risk assessment because it makes a more specific approach for molecular testing that targets the founder allele possible, thus resulting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df6e755d794c6787a91b65bb4d9a8e0
https://doi.org/10.1007/s10549-010-0882-3

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A BRCA2 founder mutation and seven novel deleterious BRCA mutations in southern Chinese women with breast and ovarian cancer

Autor: Ava Kwong, F. B. F. Law, Edmond S. K. Ma, Sharon W. W. Chan, M. Poon, T. T. Wong, Y. H. Tang, W. K. Chan, Enders K.O. Ng, KH Kwan, L. P. Wong, L. S. Ho, Marcus Ying, F. C. S. Leung, James M. Ford, H Wong

Publikováno v: Breast cancer research and treatment. 117(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186a1fbb3c7af519c108456a773a8af4
https://pubmed.ncbi.nlm.nih.gov/19353265

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Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer

Publikováno v: The HUGO Journal

Breast cancers related to BRCA mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without BRCA mutations and of carriers of BRCA1 mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2347c9a896828fa5057b6053c3ed9f
http://hdl.handle.net/10722/144981

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