Zobrazeno 1 - 10
of 63
pro vyhledávání: '"F. Anthony Romero"'
Autor:
Ryan Raisner, Samir Kharbanda, Lingyan Jin, Edwin Jeng, Emily Chan, Mark Merchant, Peter M. Haverty, Russell Bainer, Tommy Cheung, David Arnott, E. Megan Flynn, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1722-1729 (2018)
Summary: Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However, the functional impact of this modification at enhancers is poorly understood. Here, we use a chemical genetics approach to acutely block the funct
Externí odkaz:
https://doaj.org/article/30f0b373eb01444dbff75e2a8755acdb
Autor:
Denise E. de Almeida Nagata, Eugene Y. Chiang, Suchit Jhunjhunwala, Patrick Caplazi, Vidhyalakshmi Arumugam, Zora Modrusan, Emily Chan, Mark Merchant, Lingyan Jin, David Arnott, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne, Jane L. Grogan
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 269-281.e4 (2019)
Summary: Myeloid-derived suppressor cells (MDSCs) are found in most cancer malignancies and support tumorigenesis by suppressing immunity and promoting tumor growth. Here we identify the bromodomain (BRD) of CBP/EP300 as a critical regulator of H3K27
Externí odkaz:
https://doaj.org/article/59bed4a4121e435abacf7f0ac7ad65fe
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e6d4475a0ae89a8c2dfdd5ab0fdb742
https://doi.org/10.1158/0008-5472.22415367.v1
https://doi.org/10.1158/0008-5472.22415367.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 3 shows H3K27 acetylation ChIPseq QC analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477ddd9560eda30f5c026406d5682a9e
https://doi.org/10.1158/0008-5472.22421168.v1
https://doi.org/10.1158/0008-5472.22421168.v1
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Bromodomain selectivity data for GNE-049 using BROMOscan® panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b2ed65b009a3d6a8d0c6d6fdb82b76
https://doi.org/10.1158/0008-5472.22415364
https://doi.org/10.1158/0008-5472.22415364
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Regulatory T cells (Treg) are immunosuppressive and negatively impact response to cancer immunotherapies. CREB-binding protein (CBP) and p300 are closely related acetyltransferases and transcriptional coactivators. Here, we evaluate the mechanisms by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dfda38464bfe249a1e9c6500c6cdae
https://doi.org/10.1158/0008-5472.c.6510854.v1
https://doi.org/10.1158/0008-5472.c.6510854.v1
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
qPCR analysis of Myc expression after GNE-049 treatment, effects of GNE-049 combination treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348bd12eb407d5287c888e7de21bcfb1
https://doi.org/10.1158/0008-5472.22415379
https://doi.org/10.1158/0008-5472.22415379
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
GNE-049 chemical synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272c8ba9d74f81c9f661d51828b510a5
https://doi.org/10.1158/0008-5472.22415370.v1
https://doi.org/10.1158/0008-5472.22415370.v1
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Resistance invariably develops to antiandrogen therapies used to treat newly diagnosed prostate cancers, but effective treatments for castration-resistant disease remain elusive. Here, we report that the transcriptional coactivator CBP/p300 is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2a174442441346b475aa53f3b8dc698
https://doi.org/10.1158/0008-5472.c.6509253.v1
https://doi.org/10.1158/0008-5472.c.6509253.v1
Autor:
Alexander M. Taylor, Chris Bailey, Lisa D. Belmont, Robert Campbell, Nico Cantone, Alexandre Côté, Terry D. Crawford, Richard Cummings, Kevin DeMent, Martin Duplessis, Megan Flynn, Andrew C. Good, Hon-Ren Huang, Shivangi Joshi, Yves Leblanc, Jeremy Murray, Christopher G. Nasveschuk, Adrianne Neiss, Florence Poy, F. Anthony Romero, Peter Sandy, Yong Tang, Vickie Tsui, Laura Zawadzke, Robert J. Sims, James E. Audia, Steven F. Bellon, Steven R. Magnuson, Brian K. Albrecht, Andrea G. Cochran
Publikováno v:
Journal of medicinal chemistry. 65(16)
Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small molecules that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery efforts. Highly potent an