Zobrazeno 1 - 10
of 169
pro vyhledávání: '"F. Albertioni"'
Autor:
F. Albertioni, Xin Wang
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 29:414-418
Clofarabine, a new-generation purine nucleoside analogue, was thought to work via three mechanisms: incorporation into DNA; induction of apoptosis; and inhibition of ribonucleotide reductase, and showed significant efficacy in pediatric relapsed/refr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b5a488405e9400d3fe0798415a3965
https://doi.org/10.1080/15257771003738568
https://doi.org/10.1080/15257771003738568
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 20:225-232
2-Chloro-2'-deoxyadenosine (CdA), a newly developed anticancer drug, has been tested in phase II trials in the treatment of lymphoproliferative disorders. 2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine (CAFdA), an acid stable derivative of CdA with pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a897245dbe2e97377a1ba0244e3d144c
https://doi.org/10.1007/bf03189674
https://doi.org/10.1007/bf03189674
Autor:
K Wallman, G Tjønnfjord, C M Stolt, M Hedenus, D Heldal, E Hippe, F Albertioni, Stein A. Evensen, Gunnar Juliusson, Claes Malm
Publikováno v:
Journal of Clinical Oncology. 13:989-995
PURPOSE To evaluate the clinical efficacy and safety of 2-chlorodeoxyadenosine (CdA) when administered by subcutaneous injection to patients with symptomatic hairy cell leukemia (HCL), and to evaluate predictive factors for response. PATIENTS AND MET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c3f0adf146f6c05c76425c65f961e0
https://doi.org/10.1200/jco.1995.13.4.989
https://doi.org/10.1200/jco.1995.13.4.989
Publikováno v:
Journal of Liquid Chromatography. 18:1123-1135
Plasma protein binding of 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine (CAFDA), 2-chloro-2′-deoxyadenosine (CdA), 2-fluoro-1-β-D-arabinofuranosyladenine (F-araA) and structurally related analogues 2-chloro-adenosine (2-Cl-Ado), 5′-chloro-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ef0e107b19bef44c80f3d6f8a66ee7a
https://doi.org/10.1080/10826079508009280
https://doi.org/10.1080/10826079508009280
Publikováno v:
Journal of Clinical Oncology. 10:1514-1518
PURPOSE The antimetabolite 2-chloro-2'-deoxyadenosine (CdA) is a promising alternative to alkylating agents for the treatment of lymphoproliferative disorders. Its use, however, is hampered by the need for intravenous (IV) administration. The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c8bae53a30d0d8a0a4b9c95434db6e
https://doi.org/10.1200/jco.1992.10.10.1514
https://doi.org/10.1200/jco.1992.10.10.1514
Publikováno v:
British journal of haematology. 114(3)
The pyrimidine analogue cytosine arabinoside (AraC) is one of the most effective drugs used in the treatment of acute leukaemia. Overexpression of the multidrug resistance (MDR-1) gene and its product, P-glycoprotein (P-gp), is associated with cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9353d2576c4e797ef9c4a768a0ee9a7d
https://pubmed.ncbi.nlm.nih.gov/11552980
https://pubmed.ncbi.nlm.nih.gov/11552980
Autor:
K, Lotfi, E, Månsson, J, Chandra, Y, Wang, D, Xu, E, Knaust, T, Spasokoukotskaja, E, Liliemark, S, Eriksson, F, Albertioni
Publikováno v:
British journal of haematology. 113(2)
Cross-resistance between different classes of anti-neoplastic agents can jeopardize successful combination cancer chemotherapy. In this study, we observed an unexpected cross-resistance between the podophyllotoxine derivative etoposide (VP) and the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7c051a4f43b5cc8a08517bf87e02ed2
https://pubmed.ncbi.nlm.nih.gov/11380397
https://pubmed.ncbi.nlm.nih.gov/11380397
Publikováno v:
Cancer research. 59(23)
2F-Adenine arabinoside (fludarabine, Fara-A) and 2-chloro-2'-deoxyadenosine (cladribine, CdA) are nucleoside analogues with antineoplastic activity in vitro and in vivo. Lack of clinical resistance between CdA and Fara-A has been demonstrated in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5fd9039e2854b96b5af9ee263f854af
https://pubmed.ncbi.nlm.nih.gov/10606241
https://pubmed.ncbi.nlm.nih.gov/10606241
Autor:
K, Lotfi, E, Månsson, T, Spasokoukotskaja, B, Pettersson, J, Liliemark, C, Peterson, S, Eriksson, F, Albertioni
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(9)
The objective of the present study was to investigate the biochemical pharmacology of 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine (CAFdA)--a fluorinated analogue of cladribine [2-chloro-2'-deoxyadenosine, Leustatin (CdA)] with improved acid and meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0036dc9847e03634bdd441df6b15d558
https://pubmed.ncbi.nlm.nih.gov/10499616
https://pubmed.ncbi.nlm.nih.gov/10499616
Publikováno v:
Advances in experimental medicine and biology. 431
Seventeen patients with CLL were treated with oral 2-chloro-2'-deoxyadenosine (cladribine, CdA, 10 mg/m2) on 3 consecutive days and the pharmacokinetic parameters of CdA in patient plasma and its intracellular nucleotides (CdAMP, CdATP) in circulatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77ae2b5d6fcf0bb7cecfc01a97f05a42
https://pubmed.ncbi.nlm.nih.gov/9598154
https://pubmed.ncbi.nlm.nih.gov/9598154