Zobrazeno 1 - 8
of 8
pro vyhledávání: '"F. A. Tanious"'
Autor:
Brenden C. Bender, David W. Boykin, F. A. Tanious, W D Wilson, J. E. Hall, Donald R. McCurdy, Iris Francesconi, R R Tidwell
Publikováno v:
Journal of Medicinal Chemistry. 42:2260-2265
Dicationic 2,4-bis(4-amidinophenyl)furans 5-10 and 2, 4-bis(4-amidinophenyl)-3,5-dimethylfurans 14 and 15 have been synthesized. Thermal melting studies revealed high binding affinity of the compounds to poly(dA-dT) and to the duplex oligomer d(CGCGA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bde90c5fc136d6903e08c73c4c6d86
https://doi.org/10.1021/jm990071c
https://doi.org/10.1021/jm990071c
Publikováno v:
Journal of Medicinal Chemistry. 39:1452-1462
Considerable evidence now indicates that DNA is the receptor site for dicationic benzimidazole anti-opportunistic infections agents (Bell, C. A. ; Dykstra, C. C. ; Naiman, N. A. I. ; Cory, M. ; Fairley, T. A. ; Tidwell, R. R. Antimicrob. Agents Chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47ff9eef4b969a6640aa43dda623a82
https://doi.org/10.1021/jm9507946
https://doi.org/10.1021/jm9507946
Autor:
F A, Tanious, W D, Wilson, D A, Patrick, R R, Tidwell, P, Colson, C, Houssier, C, Tardy, C, Bailly
Publikováno v:
European journal of biochemistry. 268(12)
The conventional wisdom argues that DNA intercalators possess a condensed polyaromatic ring whereas DNA minor groove binders generally contain unfused aromatic heterocycles, frequently separated by amide bonds. Recently, this view has been challenged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80edc24ea4fae20611cee5e4b1741771
https://pubmed.ncbi.nlm.nih.gov/11422375
https://pubmed.ncbi.nlm.nih.gov/11422375
Publikováno v:
Journal of molecular biology. 300(2)
As part of an effort to develop a better understanding of the structural and thermodynamic principles of DNA minor groove recognition, we have investigated complexes of three diphenylfuran dications with the d(CGCGAATTCGCG)(2) duplex. The parent comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::851f0294508a939bec9eae9926d3448b
https://pubmed.ncbi.nlm.nih.gov/10873468
https://pubmed.ncbi.nlm.nih.gov/10873468
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18bf4f19147fed38dfab63e9816aa837
https://pubmed.ncbi.nlm.nih.gov/9407538
https://pubmed.ncbi.nlm.nih.gov/9407538
Publikováno v:
Biophysical chemistry. 35(2-3)
A number of unfused tricyclic aromatic intercalators have shown excellent activity as amplifiers of the anticancer activity of the bleomycins and the 4',6-diphenylpyrimidines, 2a and 2b, with terminal basic functions (4-methylpiperazino groups) have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03d65ac454230c3e879abee40dcbea7c
https://pubmed.ncbi.nlm.nih.gov/2397274
https://pubmed.ncbi.nlm.nih.gov/2397274
Publikováno v:
Anti-cancer drug design. 5(1)
A number of unfused-aromatic cations have been found to bind to DNA by intercalation and to amplify the bleomycin catalysed cleavage of DNA. These molecules are more similar in structure to unfused minor-groove binding compounds such as netropsin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3111e318873a0c645cb06e68168700d9
https://pubmed.ncbi.nlm.nih.gov/1690546
https://pubmed.ncbi.nlm.nih.gov/1690546