Výsledky vyhledávání - "F. A. Stevens"

Akademický článek

The spatial allocation of population: a review of large-scale gridded population data products and their fitness for use

Autor: S. Leyk, A. E. Gaughan, S. B. Adamo, A. de Sherbinin, D. Balk, S. Freire, A. Rose, F. R. Stevens, B. Blankespoor, C. Frye, J. Comenetz, A. Sorichetta, K. MacManus, L. Pistolesi, M. Levy, A. J. Tatem, M. Pesaresi

Publikováno v: Earth System Science Data, Vol 11, Pp 1385-1409 (2019)

Population data represent an essential component in studies focusing on human–nature interrelationships, disaster risk assessment and environmental health. Several recent efforts have produced global- and continental-extent gridded population data

Externí odkaz: https://doaj.org/article/0038a6b7b0614bd78f0c337a67947577

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Akademický článek

C8-Substituted Imidazotetrazine Analogs Overcome Temozolomide Resistance by Inducing DNA Adducts and DNA Damage

Autor: Zhikuan Yang, Danping Wei, Xiaoli Dai, Malcolm F. G. Stevens, Tracey D. Bradshaw, Ying Luo, Jihong Zhang

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Temozolomide (TMZ) is the standard of care chemotherapeutic agent used in the treatment of glioblastoma multiforme. Cytotoxic O6-methylguaine lesions formed by TMZ are repaired by O6-methyl-guanine DNA methyltransferase (MGMT), a DNA repair protein t

Externí odkaz: https://doaj.org/article/c4b941dd7ef84b71977c1b194ddd4c9b

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Modulation of the acidity of the 8-carboxamide group in the temozolomide family of antitumor imidazo[5,1-d][1,2,3,5]tetrazines

Autor: Christopher J. Moody, Malcolm F. G. Stevens, Helen S. Summers, Magdalena B. Foreiter, Tracey D. Bradshaw, William Lewis

Publikováno v: Arkivoc. 2020:36-45

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bba9060b878af1f9c4f535b689171da
https://doi.org/10.24820/ark.5550190.p011.182

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Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

Autor: Helen S. Summers, Tracey D. Bradshaw, Christopher J. Moody, Nicola Weston, Lyudmila Turyanska, Marianne Ashford, Malcolm F. G. Stevens, Kaouthar Bouzinab, Neil R. Thomas, Pavel Gershkovich

Publikováno v: ACS Applied Materials & Interfaces. 12:12609-12617

Glioblastoma multiforme (GBM) is a grade IV astrocytoma, which is the most aggressive form of brain tumor. The standard of care for this disease includes surgery, radiotherapy and temozolomide (TMZ) chemotherapy. Poor accumulation of TMZ at the tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a444ce4c13df6bd9409224878cf254
https://doi.org/10.1021/acsami.0c01514

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The antitumour activity of 2‐(4‐amino‐3‐methylphenyl)‐5‐fluorobenzothiazole in human gastric cancer models is mediated by AhR signalling

Autor: Yu-Ling Wang, Ying Luo, Yang Yan, Jihong Zhang, Tracey D. Bradshaw, Malcolm F. G. Stevens, Dong-Fang Shi, Cheng Xi, Tao Tang, Ying Liu

Publikováno v: Journal of Cellular and Molecular Medicine

Stomach cancer is the fourth most common cancer worldwide. Identification of novel molecular therapeutic targets and development of novel treatments are critical. Against a panel of gastric carcinoma cell lines, the activity of 2‐(4‐amino‐3‐m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44da230c703fc1694d22682c29c88b2
https://doi.org/10.1111/jcmm.14869

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Akademický článek

Quinols as novel therapeutic agents. 8. Applications of the Sonogashira route to thioredoxin-inhibitory indolyl-substituted quinols

Autor: Andrew J. McCarroll, Michèle B. Burke, Charles A. Laughton, Malcolm F. G. Stevens

Publikováno v: ARKIVOC, Vol 2007, Iss 11, Pp 172-182 (2007)

Externí odkaz: https://doaj.org/article/97102a69e51b4d3aadac6cd52a02dcde

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Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue

Autor: Lyudmila Turyanska, Vahid Heravi Shargh, Tracey D. Bradshaw, Stephen Lowis, William G B Singleton, Kaouthar Bouzinab, Malcolm F. G. Stevens, Beth Coyle, Stephen J. Paisey, Jeni Luckett, Alison Bienemann, Pavel Gershkovich

Publikováno v: Heravi Shargh, V, Luckett, J, Bouzinab, K, Paisey, S, Turyanska, L, Singleton, W G B, Lowis, S, Gershkovich, P, Bradshaw, T D, Stevens, M F G, Bienemann, A & Coyle, B 2021, ' Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue ', ACS Applied Materials and Interfaces, vol. 13, no. 30, pp. 35266-35280 . https://doi.org/10.1021/acsami.1c04164

The lack of clinical response to the alkylating agent temozolomide (TMZ) in pediatric diffuse midline/intrinsic pontine glioma (DIPG) has been associated with O6-methylguanine-DNA-methyltransferase (MGMT) expression and mismatch repair deficiency. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e679b6a242c9fb83cebef85c9453ba
https://hdl.handle.net/1983/745b798e-33b5-4584-be14-1e222fa29cc9

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Akademický článek

RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.

Autor: Sunil Lagah, I-Li Tan, Priya Radhakrishnan, Robert A Hirst, Jennifer H Ward, Chris O'Callaghan, Stuart J Smith, Malcolm F G Stevens, Richard G Grundy, Ruman Rahman

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e86187 (2014)

BACKGROUND: Telomeric 3' overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 l

Externí odkaz: https://doaj.org/article/fbebdeea513a4674910c7dba5d13b9ba

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