Zobrazeno 1 - 10
of 13
pro vyhledávání: '"F. A. Sinicrope"'
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
The consensus Immunoscore is a routine assay quantifying the adaptive immune response within the tumor microenvironment. It has a prognostic value that has been confirmed in a phase 3 clinical trial (NCCTG N0147) in stage III colon cancers. Moreover,
Externí odkaz:
https://doaj.org/article/f145c1368ff54607ad7ff13585b33374
Autor:
M Protani, D C Greenwood, P Cohen, N Keum, K Decorby, Caroline O. Terranova, D H Lee, J H Martin, M M Reeves, A Schienkiewitz, Annie S. Anderson, Teresa Norat, S Engel, M J Khandekar, F. Streckmann, A Mirsoian, H J Senn, M Dobbins, Ian J. Douglas, T Effertz, N R Foster, W J Murphy, Harriet Forbes, G Yothers, T J Key, D Grapov, K S Courneya, M Coory, R L Sedjo, J Baselga, F Verheyen, G B Mensink, M Haftenberger, D B Liesenfeld, P P Fahey, E G Eakin, B. C. K. Choi, T Byers, B S Cheema, S L Kilbreath, J A Ligibel, J F Fahrmann, F A Sinicrope, A. Will, B M Spiegelman, C M Alfano, K Bhaskaran, N. Bergenthal
Publikováno v:
Geburtshilfe und Frauenheilkunde. 77:227-229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c699c59328f99f8ee06b5b3cc319a83f
https://doi.org/10.1055/s-0042-121992
https://doi.org/10.1055/s-0042-121992
Publikováno v:
Cancer research. 60(15)
Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of one of the COX isozymes, COX2, has been shown to play an important role in colorectal cancer progression. Recently, however, low expression of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce1a228eb60f4df290d2d6aceabbbb96
https://pubmed.ncbi.nlm.nih.gov/10945606
https://pubmed.ncbi.nlm.nih.gov/10945606
Publikováno v:
Cancer research. 59(17)
Cyclooxygenase (COX)-2 mRNA and protein expression were found to be frequently elevated in human pancreatic adenocarcinomas and cell lines derived from such tumors. Immunohistochemistry demonstrated cytoplasmic COX-2 expression in 14 of 21 (67%) panc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7e4d4b6de2c93289a8caca4cc08bf62
https://pubmed.ncbi.nlm.nih.gov/10485483
https://pubmed.ncbi.nlm.nih.gov/10485483
Autor:
F A, Sinicrope, G, Roddey, M, Lemoine, S, Ruan, L C, Stephens, M L, Frazier, Y, Shen, W, Zhang
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(5)
p21 (p21WAF1/Cip1), a cyclin-dependent kinase inhibitor, induces G1 arrest and can inhibit the activity of the proliferating cell nuclear antigen (PCNA). We analyzed p21 expression during colorectal tumorigenesis, its association with its transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55911542adfcdd8c1c1b88041dba6379
https://pubmed.ncbi.nlm.nih.gov/9607584
https://pubmed.ncbi.nlm.nih.gov/9607584
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(12)
A disturbance in the balance between cell proliferation and cell loss, or apoptosis, may underlie neoplastic development. Therefore, we determined spontaneous apoptotic and proliferative rates in normal, hyperplastic, adenomatous, and malignant color
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a52322e664b4d753fa2aacbe8b8734a
https://pubmed.ncbi.nlm.nih.gov/9816159
https://pubmed.ncbi.nlm.nih.gov/9816159
bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: association with clinical outcome
Autor:
F A, Sinicrope, D B, Evans, S D, Leach, K R, Cleary, C J, Fenoglio, J J, Lee, J L, Abbruzzese
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(12)
The bcl-2 proto-oncogene and the p53 tumor suppressor gene are important determinants of tumor cell susceptibility to apoptosis. bcl-2 and mutant p53 proteins inhibit apoptosis in vitro and can provide prognostic information in certain tumor types. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::816a530f81b26b27bd7e80d9e8f23409
https://pubmed.ncbi.nlm.nih.gov/9816161
https://pubmed.ncbi.nlm.nih.gov/9816161
Publikováno v:
The American journal of gastroenterology. 91(9)
Radiation proctitis is a common complication of abdominal and pelvic radiotherapy; unfortunately, there is no established effective therapy for radiation proctitis. Short-chain fatty acids (SCFA) have been effectively used to treat a variety of colit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f051139d70d080270d1df598ec1a2732
https://pubmed.ncbi.nlm.nih.gov/8792704
https://pubmed.ncbi.nlm.nih.gov/8792704
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(1)
Epidemiological studies indicate that nonsteroidal anti-inflammatory agents may reduce colorectal cancer incidence and mortality. Moreover, sulindac has been shown to attenuate the growth and progression of colonic neoplasms in an experimental model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::733381f105c56f2c9984ea8928d0503f
https://pubmed.ncbi.nlm.nih.gov/9816087
https://pubmed.ncbi.nlm.nih.gov/9816087
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(10)
The bcl-2 proto-oncogene encodes a Mr 25,000 protein that has been shown to prevent apoptosis or programmed cell death. The bcl-2 protein is detectable in basal cells of normal colonic epithelium, and an altered topographic distribution of this prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85bd80d5e2f55e9b1398d116cc7c6308
https://pubmed.ncbi.nlm.nih.gov/9815900
https://pubmed.ncbi.nlm.nih.gov/9815900