VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

Autor: Thomas Thisted, F. Donelson Smith, Arnab Mukherjee, Yuliya Kleschenko, Feng Feng, Zhi-Gang Jiang, Timothy Eitas, Kanam Malhotra, Zuzana Biesova, Adejumoke Onumajuru, Faith Finley, Anokhi Cifuentes, Guolin Zhang, Gaëlle H. Martin, Yoshiko Takeuchi, Kader Thiam, Robert D. Schreiber, Edward H. van der Horst

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VIST

Externí odkaz: https://doaj.org/article/5baa81963d6e484cb872b3eac39edd59

Disaster mycology

Autor: Daniel F. Q Smith, Arturo Casadevall

Publikováno v: Biomédica: revista del Instituto Nacional de Salud, Vol 43, Iss Sp. 1, Pp 267-277 (2023)

Natural and human-made disasters have long played a role in shaping the environment and microbial communities, also affecting non-microbial life on Earth. Disaster microbiology is a new concept based on the notion that a disaster changes the environm

Externí odkaz: https://doaj.org/article/87a3b9eaeaaa41279cbbd05474c3fe86

P13 Paediatric Home Sleep studies in the UK: where are we now?

Autor: Hui-Leng Tan, F Martin Smith

Publikováno v: BMJ Open Respiratory Research, Vol 10, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/9b9e3c3576c24139aad5fe48f5c2f85c

An overview of the STEP divertor design and the simple models driving the plasma exhaust scenario

Autor: S.S. Henderson, R.T. Osawa, S.L. Newton, D. Moulton, L. Xiang, R. Futtersack, M. Kryjak, C. Ridgers, J. Karhunen, A. Jarvinen, A. Hudoba, S. Bakes, F. Eriksson, H. Meyer, M. Lord, A. Tarazona, A. Cureton, A. Barth, B. Chuilon, T. Hebrard, S. Wang, Z. Vizvary, D. Vaccaro, F. Perez Smith, J. Farrington, J. Harrison, B. Dudson, B. Lipschultz

Publikováno v: Nuclear Fusion, Vol 65, Iss 1, p 016033 (2024)

This paper presents a comprehensive overview of the preliminary divertor design and plasma exhaust scenario for the reactor-class Spherical Tokamak for Energy Production project. Due to the smaller size of the machine, with a major radius less than h

Externí odkaz: https://doaj.org/article/5f49fc0667e24754a51002d97e02fcff

JET machine operations in T&D-T

Autor: The JET Operations Team (presented by D.B. King), E. Abdelrahman, A. Abdul Hamid, N. Abid, K. Abraham, O. Adabonyan, C. Adlam, M. Afzal, M. Akhtar, V. Aldred, S. Aldworth, S. Aleiferis, M. Ali, R. Alie, R. Allan, H. Allen, E. Alli, M. Allinson, P. Almond, J. Angus, K. Antcliffe, I. Antoniou, L. Appel, C. Appelbee, C. Aramunde, N. Archer, S. Aria, H. Arkuszynski, M. Arshad, G. Artaserse, A. Ash, C. Ashe, T. Aue, D. Auld, B. Austin, Y. Austin, C. Ayres, R.B. Morales, S. Baker, S. Bakes, I. Balboa, C. Balshaw, N. Balshaw, J. Banks, J. Banner, A. Barnard, M. Barnard, M. Baruzzo, C. Basagiannis, S. Bathe Hariyanandan, P. Batistoni, R. Baughan, P. Beaumont, D. Beckett, A. Begolli, M. Beldishevski, K. Bell, E. Belonohy, J. Bentley, J. Bernardo, M. Berry, J. Bhatt, S. Bickerton, J. Bielecki, W. Bird, D. Blackett, K. Blackman, S. Blake, P. Blatchford, A. Bleasdale, A. Boboc, J. Booth, P. Boulting, M. Bowden, C. Boyd, K. Boyd, R. Bracey, D. Brennan, A. Brett, M. Bright, M. Brix, I. Brooks, B. Brown, P. Brown, M. Brown, P. Brummitt, B. Viola, A. Buckingham, M. Buckley, J. Bumpass, M. Burford, A. Burgess, J. Burton-Sweeten, A. Busse, D. Butcher, P. Cahill, P. Camp, I. Campbell, R. Canavan, J. Cane, M. Cannon, N. Canterbury, A. Carberry, P. Card, M. Carlick, M. Carlo, P. Carman, A. Carruthers, S. Carter, I.S. Carvalho, P. Carvalho, F. Casson, D. Chalk, B. Chamberlain, P. Chauhan, A. Chow, A. Churchman, D. Ciric, M. Clark, J. Clarkson, R. Clarkson, T. Clayton, M. Cleverly, P. Coates, I. Coffey, J. Collins, S. Conroy, N.J. Conway, R. Conway, J. Cook, M. Cooke, D. Coombs, P. Cooper, S. Cooper, G. Corrigan, R. Cotterell, A. Coulson, M. Cox, S. Cox, S. Cramp, D. Craven, R. Craven, M. Crick, D. Croft, T. Cronin, Z. Cui, A. Cullen, R. Cumming, C. Cummings, A. Dal Molin, P. Dalgliesh, S. Dalley, A. Danquah, S. Davies, G. Davis, H. Dawson, K. Dawson, S. Dawson, I. Day, L. de Caires, E. de la Luna, K. Deakin, J. Deane, M. Dearing, A. Dennett, T. Dickson, J. Dobrashian, T. Dochnal, S. Dorling, D. Douai, S. Dowson, J. Drewitt, G. Drummond, P. Dumortier, R. Eade, R. Eastham, K. Eden, J. Edmond, J. Edwards, P. Edwards, H. Elamin, S. Elford, H. El-Haroun, P. Ellis, C. Elsmore, S. Emery, G. Evans, S. Evans, D. Fagan, T. Farmer, I. Farquhar, R. Felton, F. Ferner, J. Fessey, P. Finburg, G. Fishpool, L. Fittill, J. Flanagan, K. Flinders, S. Foley, M. Fontana, M. Fortune, J. Foster, C. Fowler, P. Fox, O. Franklin, R. Franklin, R. Fraser, S. French, M. Furseman, A. Gabbidon, L. Garcia, J. Garcia, M. Gardener, D. Gear, T. Gedling, S. Gee, P. Gell, R. George, S. Gerasimov, M. Gethins, Z. Ghani, L. Giacomelli, C. Gibson, V. Gilsenan, C. Giroud, R. Glen, J. Goff, C. Goodman, A. Goodyear, A. Gordon, S. Gore, S. Gosden, N. Gotts, E. Gow, W. Graham, G. Graham, M. Green, R. Gregory, R. Griffiths, T. Griffiths, F. Griph, C. Grundy, T. Grundy, D. Guard, D. Guest, C. Gurl, S. Hacquin, A. Hakola, K. Hammond, H. Harmer, P. Harper, S. Harris, D. Hart, D. Hattan, A. Haupt, J. Hawes, N. Hawkes, J. Hawkins, P. Hawkins, S. Hayes, S. Hazael, D. Heads, P. Heesterman, O. Hemming, R.B. Henriques, G. Hermon, G. Hewson, T. Hibberd, M. Hill, J. Hillesheim, I. Hirb, K. Ho, C. Hogben, A. Hollingsworth, S. Hollis, M. Hook, D. Hopley, N. Horsten, A. Horton, L.D. Horton, L. Horvath, S. Hotchin, Z. Huang, E. Hubenov, V. Huber, A. Huber, C. Huddart, T. Huddleston, T. Hunter, Y. Husain, A. Hynes, J. Ingleby, S. Ives, E. Ivings, S. Jackson, T. Jackson, P. Jacquet, N. Jayasekera, I. Jepu, D. Jezzard, E. Joffrin, R. Johnson, J. Johnston, C. Jones, E. Jones, G. Jones, L. Jones, S. Jones, T. Jones, M. Jones, A. Joyce, M. Juvonen, A. Kantor, A. Kappatou, G. Karajgikar, J. Karhunen, I. Karnowska-Paterski, E. Karsakos, G. Kaveney, G. Kay, D. Keeling, T. Keenan, R. Kelly, W. Kelly, D. Kennedy, R. Kennedy, O. Kent, K. Khan, D. King, D. Kinna, V. Kiptily, K. Kirov, G. Kneale, M. Knight, P. Knight, J. Knipe, R. Knipe, S. Knipe, P. Kochanski, D. Kos, M. Kovari, E. Kowalska-Strzęciwilk, N. Kraus, M. Kresina, B. Labit, A. Laing, V. Laksharam, N. Lam, B. Lane, C. Lane, T. Lavender, A. Lawson, K. Lawson, G. Learoyd, T. Leeson, X. Lefebvre, J. Lehmann, M. Lennholm, K. Lennon, E. Lerche, S. Lesnoj, E. Letellier, L. Lewin, J. Lewis, J. Li, G. Liddiard, E. Litherland-Smith, F. Liu, R. Lobel, J. Logan, P. Lomas, C. Long, U. Losada, C. Loveridge, T. Lowe, C. Lowry, R. Lucock, G. Lyons, J. Macdonald, P. Macheta, T. Madden, J. Maddock, C.F. Maggi, J. Mailloux, A. Manning, C. Manning, N. Mantel, A. Manzanares, S. Marsden, J. Marsh, R. Marshall, A. Martin, M. Maslov, G. Matthews, N. Mayfield, M. Mayoral, R. McAdams, L. McCafferty, P. McCullen, D. McDonald, A. McDonnell, D. McGuckin, T. McIver, V. McKay, R. McKean, L. McNamee, A. McShee, R. Meadows, D. Mederick, M. Medland, K. Meghani, A. Meigs, S. Menmuir, I. Merrigan, S. Mianowski, P. Middleton, C. Miles, J. Milnes, A. Milocco, J. Mitchell, P. Mitchell, P. Monaghan, I. Monakhov, P. Moody, R. Mooney, C. Moore, N. Mooring, L. Morgan, R. Morgan, J. Morris, O. Morton, S. Morton, P. Mulvana, S. Munot, R. Munro-Smith, K. Musgrave, R. Naish, N. Neethiraj, J. Neilson, A. Newman, S. Ng, M. Nicassio, K. Nicholls, M. Nightingale, C. Noble, R. Normington, C. Nygaard, J. O’Callaghan, R. Olney, B. O’Meara, M. O’Mullane, C. O’Neill, C. Opara, K. O’Rourke, J. Ottley, K. Otu, A. Owen, N. Pace, K. Palamartchouk, D. Paley, J. Palgrave, G. Papadopoulos, V. Parail, A. Parrott, A. Parsloe, L. Parsons, R. Parsons, A. Patel, J. Patel, A. Peacock, M. Pearce, T. Pearce, I. Pearson, J. Penzo, A. Perdas, T. Pereira, C. Perez Von Thun, D. Perry, N. Petrella, M. Peyman, N. Platt, M. Poradzinski, M. Porter, M. Porton, C. Powell, J. Pozzi, M. Price, L. Price, P. Puglia, D. Pulley, K. Purahoo, M. Rainford, A. Raj, S. Randhawa, S. Rapa, K. Ravisankar, C. Rayner, A. Read, C. Reux, S. Reynolds, V. Riccardo, L. Richiusa, D. Rigamonti, F. Rimini, J. Roberts, R. Robins, S. Robinson, T. Robinson, D. Robson, S. Romanelli, F. Rose, C. Rose-Innes, D. Rouse, S. Rowe, N. Rowland, D. Rowlands, M. Rubel, K. Sabin, R. Salmon, H. Salter, A. Sanders, E. Sanders, I. Sanders, D. Sandiford, F. Sanni, R. Sarwar, R. Sayles, C. Scaysbrook, G. Scott, D. Scraggs, S. Scully, R. Sealey, E. Searle, M. Segato, M. Sertoli, C. Shanks, R. Sharma, A. Shaw, K. Sheahan, H. Sheikh, D. Shrestha, R. Siddiqui, S. Silburn, J. Silva, D. Simfukwe, J. Simpson, M. Sinclair, A. Sips, P. Sirén, S. Skeats, N. Skinner, B. Slade, J. Slater, T. Smart, G. Smith, J. Smith, N. Smith, P. Smith, T. Smith, F. P. Smith, J. Snell, K. Snelling, K. Soare, E. Solano, A. Spelzini, C. Srinivasan, Z. Stancar, P.A. Staniec, M. Stead, R. Steadman, L. Steel, D. Steele, A. Stephen, J. Stephens, L. Stevenson, P. Stevenson, C. Steventon, L. Sticklen, M. Stojanov, S. Strikwerda, C. Stuart, G. Stubbs, N. Studd, W. Studholme, H. Sun, S. Surendran, G. Szepesi, M. Szoke, H. Tan, A. Taylor, D. Taylor, K. Taylor, A. Thingore, B. Thomas, J. Thomas, A. Thorman, A. Tilley, A. Tipton, N. Tipton, H. Todd, P. Tonner, A. Tookey, M. Towndrow, M. Tsang, E. Tsitrone, I. Turner, M. Turner, G. Tvalashvili, S. Tyrrell, A. Vadgama, D. Valcarcel, Q. Van Der Westhuizen, J. Verdon, N. Vianello, A. Vittal, Z. Vizvary, B. Wakeling, M. Walker, R. Walker, T. Wall, M. Walsh, T. Walsh, J. Walters, J. Walton, R. Walton, S. Warder, F. Warren, R. Warren, J. Waterhouse, T. Webster, G. Wells, C. Wellstood, A. West, M. Wheatley, S. Whiffin, A. Whitehead, C. Whitehead, D. Whittaker, A. Widdowson, J. Wilcox, D. Wilkins, R. Wilkins, J. Williams, M. Williams, D. Willoughby, A. Wilson, I. Wilson, T. Wilson, M. Wischmeier, P. Wise, G. Withenshaw, A. Withycombe, D. Witts, J. Witts, R. Wood, L. Woodham, C. Woodley, J. Woodley, R. Woodley, B. Woods, S. Wray, T. Xu, I. Young, R. Young, K-D. Zastrow, Y. Zayachuk, M. Zerbini

Publikováno v: Nuclear Fusion, Vol 64, Iss 10, p 106014 (2024)

JET, the world’s largest operating tokamak with unique Be/W wall and tritium handling capability, completed a Deuterium-Tritium (D-T) campaign in 2021 (Maggi et al 29th Fusion Energy Conf. ) following a decade of preparatory experiments, dedicated

Externí odkaz: https://doaj.org/article/cdccaad611b94a43b0001f6c57d33c2a