Výsledky vyhledávání - "F. A. Goldbaum"

Akademický článek

A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment

Autor: A. Farias, A. Soto, F. Puttur, C. J. Goldin, S. Sosa, C. Gil, F. A. Goldbaum, P. M. Berguer

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Brucella lumazine synthase (BLS) is a homodecameric protein that activates dendritic cells via toll like receptor 4, inducing the secretion of pro-inflammatory cytokines and chemokines. We have previously shown that BLS has a therapeutic eff

Externí odkaz: https://doaj.org/article/c1e29dd9f660401a91056f73c081b0bc

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Sensing the dissociation of a polymeric enzyme by means of an engineered intrinsic probe

Autor: N, Ainciart, V, Zylberman, P O, Craig, D, Nygaard, H R, Bonomi, A A, Cauerhff, F A, Goldbaum

Publikováno v: Proteins. 79(4)

One of the most remarkable characteristics of Brucella lumazine synthase (BLS) is its versatility to undergo reversible dissociation and reassociation as a polymeric scaffold. We have proposed a mechanism of dissociation and unfolding of BLS. Using s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbb081f35516146fcb2ba56c3f2e5e55
https://pubmed.ncbi.nlm.nih.gov/21246631

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Divergence in macromolecular assembly: X-ray crystallographic structure analysis of lumazine synthase from Brucella abortus

Autor: B C, Braden, C A, Velikovsky, A A, Cauerhff, I, Polikarpov, F A, Goldbaum

Publikováno v: Journal of molecular biology. 297(5)

We have determined the three-dimensional structure of 6, 7-dimethyl-8-ribityllumazine synthase (lumazine synthase) from Brucella abortus, the infectious organism of the disease brucellosis in animals. This enzyme catalyses the formation of 6, 7-dimet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5864892a6de93ae379b49a59b96bdf3b
https://pubmed.ncbi.nlm.nih.gov/10764570

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[Diagnosis and progress analysis of human brucellosis via new serological methods]

Autor: J C, Wallach, P C, Baldi, F A, Goldbaum, C A, Velikovsky, C A, Fossati

Publikováno v: Revista Argentina de microbiologia. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00b5c67b78fc1fe5985f730ec5d7d2c9
https://pubmed.ncbi.nlm.nih.gov/10509412

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[Determination of antiprotein antibodies for the diagnosis of brucellosis in animals]

Autor: P C, Baldi, F A, Goldbaum, C A, Velikovsky, J C, Wallach, C A, Fossati

Publikováno v: Revista Argentina de microbiologia. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::611fb53d237cfb179dba262f08b473a1
https://pubmed.ncbi.nlm.nih.gov/10509413

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Lack of significant differences in association rates and affinities of antibodies from short-term and long-term responses to hen egg lysozyme

Autor: F A, Goldbaum, A, Cauerhff, C A, Velikovsky, A S, Llera, M M, Riottot, R J, Poljak

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(10)

The affinities (Ka) and association rate constants (kon) of 23 mouse (BALB/c) anti-lysozyme mAbs obtained after short and prolonged immunizations have been measured by plasmon resonance techniques. The affinities for the 23 Abs, measured using their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a046baa6ee408cf0cb02c04803b2cde
https://pubmed.ncbi.nlm.nih.gov/10229844

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The effect of water activity on the association constant and the enthalpy of reaction between lysozyme and the specific antibodies D1.3 and D44.1

Autor: F A, Goldbaum, F P, Schwarz, E, Eisenstein, A, Cauerhff, R A, Mariuzza, R J, Poljak

Publikováno v: Journal of molecular recognition : JMR. 9(1)

The reactions of lysozyme with the specific monoclonal antibody D1.3, its Fv fragment and a mutant of the Fv, were studied under conditions of reduced water activity through the addition of the cosolutes glycerol, ethanol, dioxane and methanol. Titra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42c1904fadf326d5472290a82c36615e
https://pubmed.ncbi.nlm.nih.gov/8723314

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Thermodynamics of antigen-antibody binding using specific anti-lysozyme antibodies

Autor: F P, Schwarz, D, Tello, F A, Goldbaum, R A, Mariuzza, R J, Poljak

Publikováno v: European journal of biochemistry. 228(2)

Titration calorimetry measurements on the binding of hen lysozyme to the specific monoclonal IgG antibodies D1.3, D11.15, D44.1, F9.13.7, F10.6.6, their papain-cleaved antigen binding fragments (Fab) and their protein-engineered fragments consisting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e009c46a20b5064534588e6b9fea3da6
https://pubmed.ncbi.nlm.nih.gov/7705353

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Human brucellosis: immunoblotting analysis of three Brucella abortus antigenic fractions allows the detection of components of diagnostic importance

Autor: F A, Goldbaum, L, Morelli, J, Wallach, C P, Rubbi, C A, Fossati

Publikováno v: Medicina. 51(3)

Results indicating that analysis of the immune humoral response of brucellosis patients by immunoblotting provides useful information for the characterization of antigenic fractions of possible diagnostic importance in human brucellosis are presented

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15bf490b842adedac480239aa3a84699
https://pubmed.ncbi.nlm.nih.gov/1726568

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