Zobrazeno 1 - 10
of 45
pro vyhledávání: '"F. A. Gesek"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 284:F113-F121
Nephropathy is a major contributor to overall morbidity and mortality in diabetic patients. Early renal changes during diabetes include Na retention and renal hypertrophy. Tumor necrosis factor (TNF) is elevated during diabetes and is implicated in t
Autor:
F. A. Gesek, Fengming Liu
Publikováno v:
American Journal of Physiology-Renal Physiology. 280:F415-F425
The Na+/H+exchanger (NHE) regulates intracellular pH, cell volume, Na+absorption and H+secretion in epithelial cells of the renal proximal tubule (PT). α1-Adrenergic receptors (ARs) increase NHE activity in PT cells. The purpose of this study was to
Publikováno v:
Endocrinology. 141:4185-4193
PTH regulates calcium homeostasis through direct actions on its cognate type I receptor in the kidney and bone. PTH inhibits phosphate transport in renal proximal (PCT) tubules and stimulates calcium absorption by distal convoluted tubules (DCT). We
Publikováno v:
Endocrinology. 140:301-309
PTH is an 84-amino acid protein. Occupancy of its cognate receptor generally results in activation of adenylyl cyclase and/or phosphoinositide-specific phospholipase Cβ (PLCβ). In the kidney, PTH receptors are present on proximal and distal tubule
Autor:
F. A. Gesek
Publikováno v:
Hypertension. 33:524-529
Abstract —α-Adrenergic receptor (AR) activation enhances sodium retention in certain forms of hypertension. The objective of the present study was to understand the role of α-ARs in regulating sodium transport by distal tubules (DT). DT cells wer
Autor:
Harriet S. Tenenhouse, P. A. Friedman, Josée Martel, Bonita Coutermarsh, F. A. Gesek, Claude Gauthier
Publikováno v:
Journal of Bone and Mineral Research. 13:590-597
While there is considerable evidence for phosphate (Pi) reabsorption in the distal tubule, Pi transport and its regulation have not been well characterized in this segment of the nephron. In the present study, we examined Na+-dependent Pi transport i
Publikováno v:
American Journal of Physiology-Renal Physiology. 271:F560-F570
Renal distal convoluted tubules (DCT) are a major site of hormone-regulated, active calcium absorption. Calcium exit across basolateral plasma membranes is thought to be mediated by Na+/Ca2+ exchange and a Ca(2+)-ATPase. In this report the presence a
Autor:
F. A. Gesek, P. A. Friedman
Publikováno v:
Kidney International. 48(5):1427-1434
Stimulation of calcium transport by amiloride in mouse distal convoluted tubule cells. This study examined the mechanism by which amiloride dissociates Na and Ca transport in distal convoluted tubules. Control rates of Na uptake averaged 288 nmol/(mi
Autor:
F. A. Gesek, P. A. Friedman
Publikováno v:
Physiological Reviews. 75:429-471
The kidneys play a vital role in mineral homeostasis. In this review, the handling of calcium and the methods currently applied to measuring its intracellular concentration are discussed. The bulk of calcium absorption proceeds in proximal tubules, w
Autor:
F. A. Gesek, P. A. Friedman
Publikováno v:
Toxicology and Applied Pharmacology. 128:257-263
Cadmium is transported by and accumulated in the kidney, which is a primary site of its toxicity. Most cadmium is reabsorbed and accumulated by proximal tubules. However, evidence for distal tubule toxicity suggests that transport may also proceed at