Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

Autor: Patricia P. Centeno, Amanda Herberger, Hee-Chang Mun, Chialing Tu, Edward F. Nemeth, Wenhan Chang, Arthur D. Conigrave, Donald T. Ward

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Elevated inorganic phosphate levels promote excessive parathyroid hormone secretion, which contributes to the aetiology of secondary hyperparathyroidism. Here, the authors show that phosphate directly inhibits the calcium-sensing receptor, the main r

Externí odkaz: https://doaj.org/article/c08a3a761322408bb35d7a424c6b5065

Association of Age with Optimal Medical Therapy in Patients with Chronic Heart Failure

Autor: Vitoria A. A. Koga, Luiza Dall’Asta, Thiago L. P. Jacyntho, Leonardo C. De-Marchi, Rodrigo P. Mulinari, Bruna A. Ladeira, Maria E. R. F. Nemeth, Odilson M. Silvestre, Marcely Gimenes Bonatto, Lidia Ana Zytynski Moura, Miguel Morita Fernandes-Silva

Publikováno v: ABC: Heart Failure & Cardiomyopathy. 2:138-145

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39287d3689ccb6a1c78bb197338ebcf9
https://doi.org/10.36660/abchf.20220050

Harnessing SLE Autoantibodies for Intracellular Delivery of Biologic Therapeutics

Autor: Renata E. Gordon, Iqbal S. Grewal, Russell B. Lingham, Sanjaya Singh, Jennifer F. Nemeth

Publikováno v: Trends in Biotechnology. 39:298-310

Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficulty blockin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f2664cb5692f8db7ee4d3bc38ac0de
https://doi.org/10.1016/j.tibtech.2020.07.003

Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia

Autor: James Lai, Edward F. Nemeth, Kevin J. Martin, Jiahong Xu, Debra Drayer, Donald T. Ward, Carol Moore, William G. Goodman, Yun Chon

Publikováno v: J Am Soc Nephrol
Goodman, W G, Ward, D T, Martin, K J, Drayer, D, Moore, C, Xu, J, Lai, J, Chon, Y & Nemeth, E F 2022, ' Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 1, pp. 201-212 . https://doi.org/10.1681/ASN.2021060825

BACKGROUND: Phosphorus levels in the range seen clinically among patients undergoing dialysis have been reported to attenuate calcium receptor activation and modify parathyroid hormone (PTH) release from isolated parathyroid glands in vitro. Some cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4159c89124255059d327b10b8253af7
https://europepmc.org/articles/PMC8763177/

Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: The Extracellular Calcium Receptor and an Innovative Medical Approach to Control Secondary Hyperparathyroidism by Calcimimetics

Autor: Nobuo Nagano, Edward F. Nemeth

Publikováno v: Journal of Pharmacological Sciences, Vol 97, Iss 3, Pp 355-360 (2005)

Circulating levels of calcium ion (Ca2+) are maintained within a narrow physiological range mainly by the action of parathyroid hormone (PTH) secreted from parathyroid cells. Parathyroid cells can sense small fluctuations in plasma Ca2+ levels by vir

Externí odkaz: https://doaj.org/article/6f3296d964c94b669dc0dd34d0992a7f