Zobrazeno 1 - 10
of 46
pro vyhledávání: '"F W Alt"'
Publikováno v:
The Journal of Immunology. 158:3738-3745
IL-2 was initially defined as a T lymphocyte growth factor, but recent studies have provided evidence that it may also play a role in regulating T cell differentiation, apoptosis, and tolerance. To examine the contribution of IL-2 to these processes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3316e59c085216c28fc81a8d48141d09
https://doi.org/10.4049/jimmunol.158.8.3738
https://doi.org/10.4049/jimmunol.158.8.3738
Publikováno v:
International Immunology. 7:1637-1647
Myc family proteins are thought to be transcription factors involved in regulation of cell growth and differentiation. N-myc is expressed at the pre-B cell stage of B cell differentiation and is dramatically induced by the pre-B cell growth factor, I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d05737419bfe9b6177e73a0a900f618
https://doi.org/10.1093/intimm/7.10.1637
https://doi.org/10.1093/intimm/7.10.1637
Publikováno v:
The Journal of Immunology. 154:3213-3221
Thymocytes mature in response to the cues from the thymic micro-environment, which regulate stage-specific gene expression during development. We find that several proteins that bind the kappa B sequence in vitro are constitutively activated in fresh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01922832ec82c1f0128f57023e1c13d9
https://doi.org/10.4049/jimmunol.154.7.3213
https://doi.org/10.4049/jimmunol.154.7.3213
Publikováno v:
Immunology Today. 13:306-314
The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of eno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05ade328bb1ff9a86bb125cf462c445
https://doi.org/10.1016/0167-5699(92)90043-7
https://doi.org/10.1016/0167-5699(92)90043-7
Publikováno v:
International Immunology. 3:751-760
The immunoglobulin light chain V kappa 1 gene family is polymorphic in murine inbred strains and this family has been subdivided into five sub-groups (V kappa 1A-E). The V kappa 1A sub-group contributes to approximately 2% of the total serum immunogl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4c30f05c047d760d8092b60904f77c
https://doi.org/10.1093/intimm/3.8.751
https://doi.org/10.1093/intimm/3.8.751
Publikováno v:
Journal of internal medicine. 263(2)
Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64e7040b90425b85ee5ba99a8faad713
https://pubmed.ncbi.nlm.nih.gov/18226091
https://pubmed.ncbi.nlm.nih.gov/18226091
Publikováno v:
The Journal of Immunology. 144:2821-2828
We have cloned and determined the nucleotide sequence of the Ig VH and VL region genes of an IgM kappa mAb that binds to denatured DNA and myelin from a patient (POP) with chronic lymphocytic leukemia and peripheral neuropathy. Sequence analysis indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ed8b0173c3da38cc73b8ab4f34fa8f
https://doi.org/10.4049/jimmunol.144.7.2821
https://doi.org/10.4049/jimmunol.144.7.2821
Publikováno v:
Immunity. 15(4)
TNF receptor-associated factor 1 (TRAF1) is a unique TRAF protein because it lacks a RING finger domain and is predominantly expressed in activated lymphocytes. To elucidate the function of TRAF1, we generated TRAF1-deficient mice. TRAF1(-/-) mice ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d48c0ebd80b2fa733e4e9318255e919
https://pubmed.ncbi.nlm.nih.gov/11672546
https://pubmed.ncbi.nlm.nih.gov/11672546
Publikováno v:
Advances in immunology. 75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bee5e58a5d44c28c8376640868c7eda1
https://pubmed.ncbi.nlm.nih.gov/10879282
https://pubmed.ncbi.nlm.nih.gov/10879282
Autor:
R J, Monroe, B P, Sleckman, B C, Monroe, B, Khor, S, Claypool, R, Ferrini, L, Davidson, F W, Alt
Publikováno v:
Immunity. 10(5)
We have used gene-targeted mutation to assess the role of the T cell receptor delta (TCR delta) enhancer (E delta) in alphabeta and gammadelta T cell development. Mice lacking E delta exhibited no defects in alphabeta T cell development but had a sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34076a3b466f94f960a004140b66e1f9
https://pubmed.ncbi.nlm.nih.gov/10367896
https://pubmed.ncbi.nlm.nih.gov/10367896