Zobrazeno 1 - 10
of 13
pro vyhledávání: '"F W, Ninteman"'
Autor:
M R Feng, D S Wright, C A Strenkoski, C L Christoffersen, A E Corbin, Y Wang, Leonard T. Meltzer, E V Tucker, James N. Wiley, Thomas G. Heffner, F W Ninteman
Publikováno v:
Pharmaceutical Research. 14:329-336
Purpose. To study the pharmacokinetics (PK) and pharmacodynamics (PD) of an investigational antipsychotic agent, CI-1007, in rats and monkeys. Methods. CI-1007 and a pharmacologically active metabolite, PD 147693 (Ml), were evaluated in animal antips
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b3b39c31d10424c97038a2f13b08540
https://doi.org/10.1023/a:1012050121937
https://doi.org/10.1023/a:1012050121937
Autor:
Haile Tecle, Y Pei, Thomas G. Heffner, James N. Wiley, Steven Z. Whetzel, F W Ninteman, Hyacinth C. Akunne, A E Corbin, Thomas A. Pugsley
Publikováno v:
Neuropharmacology. 36:51-62
The pharmacology of PD 144418 (1-propyl-5-(3-p-tolyl-isoxazol-5-yl)-1,2,3,6-tetrahydropyridine) was characterized using neurochemical, biochemical and behavioral techniques. For sigma (σ1 and σ2, respectively) sites, PD 144418 affinities were deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ef049a8056f7144948526d90bd42fd
https://doi.org/10.1016/s0028-3908(96)00161-x
https://doi.org/10.1016/s0028-3908(96)00161-x
Autor:
Lawrence D. Wise, Thomas G. Heffner, F W Ninteman, Leonard T. Meltzer, Thomas A. Pugsley, C L Christoffersen, A E Corbin, David Juergen Wustrow, James N. Wiley
Publikováno v:
Neuropharmacology. 39(7)
PD 158771 has been described in receptor binding and biochemical tests as a partial agonist at dopamine (DA) D2 and D3 receptors as well as an agonist at serotonin (5-HT) 1A receptors. The present studies describe the profile of PD 158771 in rodent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd5f73f80b9860058da3ac56820dba9
https://pubmed.ncbi.nlm.nih.gov/10760363
https://pubmed.ncbi.nlm.nih.gov/10760363
Autor:
M R, Feng, A E, Corbin, Y, Wang, C L, Christoffersen, J N, Wiley, C A, Strenkoski, E V, Tucker, F W, Ninteman, L T, Meltzer, T G, Heffner, D S, Wright
Publikováno v:
Pharmaceutical research. 14(3)
To study the pharmacokinetics (PK) and pharmacodynamics (PD) of an investigational antipsychotic agent, CI-1007, in rats and monkeys.CI-1007 and a pharmacologically active metabolite, PD 147693 (M1), were evaluated in animal antipsychotic tests (inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d62a2cafc196dcb1f1ac84f1a115617
https://pubmed.ncbi.nlm.nih.gov/9098876
https://pubmed.ncbi.nlm.nih.gov/9098876
Autor:
L T, Meltzer, C L, Christoffersen, A E, Corbin, F W, Ninteman, K A, Serpa, J N, Wiley, L D, Wise, T G, Heffner
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(2)
CI-1007 has been described in receptor binding and biochemical tests as a dopamine (DA) partial agonist that exhibits DA autoreceptor agonist effects. The present studies describe the profile of CI-1007 in electrophysiological and behavioral tests. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76158987fd3019acab7f2e2df9ef8286
https://pubmed.ncbi.nlm.nih.gov/7636754
https://pubmed.ncbi.nlm.nih.gov/7636754
Autor:
L T, Meltzer, B W, Caprathe, C L, Christoffersen, A E, Corbin, J C, Jaen, F W, Ninteman, T A, Pugsley, K A, Serpa, Y H, Shih, S Z, Whetzel
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(3)
(+/-)-PD 128483, ((+/-)-4,5,5a,6,7,8-hexahydro-6-methylthiazolo[4,5-f]-quinolin+ ++-2-amine, maleate (1:1)), is a racemic compound that is a p.o. active dopamine (DA) partial agonist that has DA autoreceptor agonist effects and displays antipsychotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1dd1554ece7d98148d5481340d4d35f
https://pubmed.ncbi.nlm.nih.gov/8103791
https://pubmed.ncbi.nlm.nih.gov/8103791
Autor:
B. P. H. Poschel, F. W. Ninteman
Publikováno v:
Drug Development Research. 1:163-166
The effect of Hydergine on intracranial self-stimulation was tested in male albino Holtzman rats. The rats had monopolar electrodes implanted in the medial forebrain bundle of the posterior hypothalamus. Hydergine was given orally at 40 and 80 mg/kg.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607f8fd63048c3048f4a3fd491adc138
https://doi.org/10.1002/ddr.430010209
https://doi.org/10.1002/ddr.430010209
Publikováno v:
Experientia. 41:1153-1156
Following oral or intravenous administration, a representative cognition activator drug, pramiracetam sulfate, is shown to have a pharmacologic therapeutic window at three different levels of study: learned behavior, gross EEG activity of the frontal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6dcf1f46befcf199df6b4a54343d117
https://doi.org/10.1007/bf01951704
https://doi.org/10.1007/bf01951704
Autor:
F. W. Ninteman, B. P. H. Poschel
Publikováno v:
Psychological Reports. 16:585-591
Summary.-Rats were implanted with permanent electrodes in the medial hypothalamus, an area where the duration of electrical stimulation seems the main determinant of the centrally-elicited reinforcing effect, with brief stimulation yielding reward an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd893449b4c8ce206ee94fd3b99e1c6
https://doi.org/10.2466/pr0.1965.16.2.585
https://doi.org/10.2466/pr0.1965.16.2.585
Publikováno v:
Experientia. 41:1433-1435
The basal EEG profile of the aged Fisher-344 rat was consistently different from that of the young rat, showing dominant high voltage slow-wave components. These slow waves were present in both the frontal cerebral cortex and dorsal hippocampus. Abse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35da398a47c80843e8647da6d6ebb31d
https://doi.org/10.1007/bf01950020
https://doi.org/10.1007/bf01950020