Zobrazeno 1 - 10
of 540
pro vyhledávání: '"F Vallejo"'
Autor:
Taopeng Wang, Michael J. Roach, Kate Harvey, Javier Escudero Morlanes, Beata Kiedik, Ghamdan Al-Eryani, Alissa Greenwald, Nikolaos Kalavros, Felipe Segato Dezem, Yuling Ma, Yered H. Pita-Juarez, Kellie Wise, Cyril Degletagne, Anna Elz, Azi Hadadianpour, Jack Johanneson, Fiona Pakiam, Heeju Ryu, Evan W. Newell, Laurie Tonon, Andrew Kohlway, Tingsheng Drennon, Jawad Abousoud, Ryan Stott, Paul Lund, Jens Durruthy, Andres F. Vallejo, Wenyan Li, Robert Salomon, Dominik Kaczorowski, Joanna Warren, Lisa M. Butler, Sandra O’Toole, Jasmine Plummer, Ioannis S. Vlachos, Joakim Lundeberg, Alexander Swarbrick, Luciano G. Martelotto
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Formalin-fixed paraffin-embedded (FFPE) samples are valuable but underutilized in single-cell omics research due to their low RNA quality. In this study, leveraging a recent advance in single-cell genomic technology, we introduce snPATHO-seq
Externí odkaz:
https://doaj.org/article/e72696809e1b4d6fbd26435761d09282
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Publikováno v:
Revista Colombiana de Nefrología, Vol 1, Iss Supl. 1 (2014)
La hipertensión resistente es un problema clínico por la dificultad de su tratamiento y el aumento de morbimortalidad que conlleva. Se ha demostrado que la denervación renal por catéter mejora el control de estos pacientes. Se describen los prime
Externí odkaz:
https://doaj.org/article/0322fb654f4c4f9d88839877acbb9254
Autor:
Leilane Oliveira Gonçalves, Andrés F. Vallejo Pulido, Fernando Augusto Siqueira Mathias, Alexandre Estevão Silvério Enes, Maria Gabriela Reis Carvalho, Daniela de Melo Resende, Marta E. Polak, Jeronimo C. Ruiz
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Leishmania amazonensis and Leishmania major are the causative agents of cutaneous and mucocutaneous diseases. The infections‘ outcome depends on host–parasite interactions and Th1/Th2 response, and in cutaneous form, regulation of Th17 cytokines
Externí odkaz:
https://doaj.org/article/63f8b76b136e447eb52c9620b10e1355
Autor:
Heather C. West, James Davies, Stephen Henderson, Oluyori K. Adegun, Sophie Ward, Ivana R. Ferrer, Chanidapa A. Tye, Andres F. Vallejo, Laura Jardine, Matthew Collin, Marta E. Polak, Clare L. Bennett
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110819- (2022)
Summary: T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute g
Externí odkaz:
https://doaj.org/article/960eba7bb8e8431f8c5a9ff4e7e81b08
Autor:
Jelmer Legebeke, Jenny Lord, Rebekah Penrice-Randal, Andres F. Vallejo, Stephen Poole, Nathan J. Brendish, Xiaofeng Dong, Catherine Hartley, John W. Holloway, Jane S. Lucas, Anthony P. Williams, Gabrielle Wheway, Fabio Strazzeri, Aaron Gardner, James P. R. Schofield, Paul J. Skipp, Julian A. Hiscox, Marta E. Polak, Tristan W. Clark, Diana Baralle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The worldwide COVID-19 pandemic has claimed millions of lives and has had a profound effect on global life. Understanding the body’s immune response to SARS-CoV-2 infection is crucial in improving patient management and prognosis. In this study we
Externí odkaz:
https://doaj.org/article/f46b555a1c314f3fb50bd6cabe819aa8
Autor:
Sofia Sirvent, Andres F. Vallejo, James Davies, Kalum Clayton, Zhiguo Wu, Jeongmin Woo, Jeremy Riddell, Virendra K. Chaudhri, Patrick Stumpf, Liliya Angelova Nazlamova, Gabrielle Wheway, Matthew Rose-Zerilli, Jonathan West, Mario Pujato, Xiaoting Chen, Christopher H. Woelk, Ben MacArthur, Michael Ardern-Jones, Peter S. Friedmann, Matthew T. Weirauch, Harinder Singh, Marta E. Polak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulate
Externí odkaz:
https://doaj.org/article/b437083920e842f086e6d17c31b3b048
Autor:
Theresa J. Hydes, Matthew D. Blunt, Jennifer Naftel, Andres F. Vallejo, Grégory Seumois, Alice Wang, Pandurangan Vijayanand, Marta E. Polak, Salim I. Khakoo
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural killer (NK) cells are innate immune cells that interface with the adaptive immune system to generate a pro-inflammatory immune environment. Primary Biliary Cholangitis (PBC) is a hepatic autoimmune disorder with extrahepatic associations incl
Externí odkaz:
https://doaj.org/article/2b014133bbf04acaa750cbfc5f905fdc
Autor:
Sofia Sirvent, Andres F. Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G. Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S. N. Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J. Hall, Peter S. Friedmann, Harinder Singh, Clare L. Bennett, Michael R Ardern-Jones, Marta E. Polak
Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge study, exposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7594d3d571275b3965437167b515896
https://eprints.soton.ac.uk/477595/
https://eprints.soton.ac.uk/477595/
Publikováno v:
BMC Health Services Research, Vol 17, Iss 1, Pp 1-7 (2017)
Abstract Background Hepatitis C is an important public health problem about which there is currently scarce epidemiological information. The objective of this study is to describe and analyse the demographic and epidemiological characteristics of hos
Externí odkaz:
https://doaj.org/article/2ace63e8ef374acf845b554e399725cb