Zobrazeno 1 - 10
of 1 828
pro vyhledávání: '"F Ulrich"'
Publikováno v:
eLife, Vol 10 (2021)
The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G4C2 repeat expansion in the C9orf72 gene. This expansion gives rise to translation of aggregating dipeptide repeat (DPR) proteins, including poly-GA as
Externí odkaz:
https://doaj.org/article/b2c40997a5ee4b7ab60a50d8173ca2dd
Autor:
Andreas Bracher, Simanta S Paul, Huping Wang, Nadine Wischnewski, F Ulrich Hartl, Manajit Hayer-Hartl
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0230090 (2020)
Chaperonins are ubiquitous molecular chaperones found in all domains of life. They form ring-shaped complexes that assist in the folding of substrate proteins in an ATP-dependent reaction cycle. Key to the folding cycle is the transient encapsulation
Externí odkaz:
https://doaj.org/article/6fa832ffdb6c4307a1d5b9e22bf8b01a
Autor:
Rabea Lange, Juliane Glaubitz, Fabian Frost, Andreas Geisz, Ali A. Aghdassi, F. Ulrich Weiss, Matthias Sendler
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The exocrine pancreas is the main source of digestive enzymes which are released from secretory vesicles of acinar cells into the small intestine. Enzymes, including amylases, proteases and lipases, degrade the ingested food and thus determi
Externí odkaz:
https://doaj.org/article/4e784e7b78f54ba38d5075d7823f12f8
Autor:
Georg Krainer, Raphael P. B. Jacquat, Matthias M. Schneider, Timothy J. Welsh, Jieyuan Fan, Quentin A. E. Peter, Ewa A. Andrzejewska, Greta Šneiderienė, Magdalena A. Czekalska, Hannes Ausserwoeger, Lin Chai, William E. Arter, Kadi L. Saar, Therese W. Herling, Titus M. Franzmann, Vasilis Kosmoliaptsis, Simon Alberti, F. Ulrich Hartl, Steven F. Lee, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The physical characterization of proteins in terms of their sizes, interactions, and assembly states is key to understanding their biological function and dysfunction. However, this has remained a difficult task because proteins are often hi
Externí odkaz:
https://doaj.org/article/a359ec4607614996aebacbbb2897fd7b
Autor:
Enrique Rayo, Gabriel F. Ulrich, Niklaus Zemp, Michael Greeff, Verena J. Schuenemann, Alex Widmer, Martin C. Fischer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The millions of specimens stored in entomological collections provide a unique opportunity to study historical insect diversity. Current technologies allow to sequence entire genomes of historical specimens and estimate past genetic diversit
Externí odkaz:
https://doaj.org/article/82b3b8a630114cd587ef6e2a29b24768
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135448 (2015)
The most prevalent form of the Rubisco enzyme is a complex of eight catalytic large subunits (RbcL) and eight regulatory small subunits (RbcS). Rubisco biogenesis depends on the assistance by specific molecular chaperones. The assembly chaperone RbcX
Externí odkaz:
https://doaj.org/article/8018cee3ee3442d9bef399e5eec1a8e5
Autor:
Julia Leitman, Boaz Barak, Ron Benyair, Marina Shenkman, Uri Ashery, F Ulrich Hartl, Gerardo Z Lederkremer
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90803 (2014)
A hallmark of Huntington's disease is the pronounced sensitivity of striatal neurons to polyglutamine-expanded huntingtin expression. Here we show that cultured striatal cells and murine brain striatum have remarkably low levels of phosphorylation of
Externí odkaz:
https://doaj.org/article/ffc97df47e8042c1b63b53fed4415932
Autor:
Nikolas Furthmann, Verian Bader, Lena Angersbach, Alina Blusch, Simran Goel, Ana Sánchez-Vicente, Laura J. Krause, Sarah A. Chaban, Prerna Grover, Victoria A. Trinkaus, Eva M. van Well, Maximilian Jaugstetter, Kristina Tschulik, Rune Busk Damgaard, Carsten Saft, Gisa Ellrichmann, Ralf Gold, Arend Koch, Benjamin Englert, Ana Westenberger, Christine Klein, Lisa Jungbluth, Carsten Sachse, Christian Behrends, Markus Glatzel, F. Ulrich Hartl, Ken Nakamura, Chadwick W. Christine, Eric J. Huang, Jörg Tatzelt, Konstanze F. Winklhofer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in innate immune signaling, cell death regulation and host-pathogen interactions. Here we identify an NF-κB-independent function of NEMO in proteostasis
Externí odkaz:
https://doaj.org/article/254c39b4dc224a428f4f65c841b52060
Autor:
Cairo, Lucas V., Hong, Xiaoyu, Müller, Martin B.D., Yuste-Checa, Patricia, Jagadeesan, Chandhuru, Bracher, Andreas, Park, Sae-Hun, Hayer-Hartl, Manajit, Hartl, F. Ulrich
Publikováno v:
In Cell 22 August 2024 187(17):4656-4673
Autor:
Hipp, Mark S., Hartl, F. Ulrich
Publikováno v:
In Journal of Molecular Biology 15 July 2024 436(14)