Zobrazeno 1 - 10
of 113
pro vyhledávání: '"F Thomas Wunderlich"'
Autor:
Isabel Mulet, Carmen Grueso-Cortina, Mireia Cortés-Cano, Daniela Gerovska, Guangming Wu, Stefania Alexandra Iakab, Daniel Jimenez-Blasco, Andrea Curtabbi, Pablo Hernansanz-Agustín, Harmony Ketchum, Israel Manjarrés-Raza, F. Thomas Wunderlich, Juan Pedro Bolaños, Meelad M. Dawlaty, Carsten Hopf, José Antonio Enríquez, Marcos J. Araúzo-Bravo, Natalia Tapia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract TET-family members play a critical role in cell fate commitment. Indeed, TET3 is essential to postnatal development due to yet unknown reasons. To define TET3 function in cell differentiation, we have profiled the intestinal epithelium at si
Externí odkaz:
https://doaj.org/article/bc646249624b4d23967654764f32eee6
Autor:
Stephan Dodt, Noah V. Widdershooven, Marie-Luise Dreisow, Lisa Weiher, Lukas Steuernagel, F. Thomas Wunderlich, Jens C. Brüning, Henning Fenselau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Efficient control of feeding behavior requires the coordinated adjustment of complex motivational and affective neurocircuits. Neuropeptides from energy-sensing hypothalamic neurons are potent feeding modulators, but how these endogenous sig
Externí odkaz:
https://doaj.org/article/b77a139245084c57b73e0de421d41fff
Autor:
Sabrina Klebow, Matthias Hahn, Alexei Nikoalev, F Thomas Wunderlich, Nadine Hövelmeyer, Susanne H Karbach, Ari Waisman
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151913 (2016)
Psoriasis is an autoimmune skin disease that is associated with aberrant activity of immune cells and keratinocytes. In mice, topical application of TLR7/8 agonist IMQ leads to a skin disorder resembling human psoriasis. Recently, it was shown that t
Externí odkaz:
https://doaj.org/article/847f6cc0a23042849d07ba7afc44dc6a
Autor:
Simone A Nish, Dominik Schenten, F Thomas Wunderlich, Scott D Pope, Yan Gao, Namiko Hoshi, Shuang Yu, Xiting Yan, Heung Kyu Lee, Lesley Pasman, Igor Brodsky, Brian Yordy, Hongyu Zhao, Jens Brüning, Ruslan Medzhitov
Publikováno v:
eLife, Vol 3 (2014)
Innate immune recognition is critical for the induction of adaptive immune responses; however the underlying mechanisms remain incompletely understood. In this study, we demonstrate that T cell-specific deletion of the IL-6 receptor α chain (IL-6Rα
Externí odkaz:
https://doaj.org/article/e636e10d03cd4a6ca2320352758b15b1
Autor:
Martin Pal, Claudia M Wunderlich, Gabriele Spohn, Hella S Brönneke, Marc Schmidt-Supprian, F Thomas Wunderlich
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54247 (2013)
Obesity and associated metabolic disturbances, such as increased circulating fatty acids cause prolonged low grade activation of inflammatory signaling pathways in liver, skeletal muscle, adipose tissue and even in the CNS. Activation of inflammatory
Externí odkaz:
https://doaj.org/article/84b25fe28b1f4fdc891db5baa3e00260
Autor:
Jan Ackermann, Lilli Arndt, Janine Fröba, Andreas Lindhorst, Markus Glaß, Michaela Kirstein, Constance Hobusch, F. Thomas Wunderlich, Julia Braune, Martin Gericke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionObesity is associated with chronic low-grade inflammation of adipose tissue (AT) and an increase of AT macrophages (ATMs) that is linked to the onset of type 2 diabetes. We have recently shown that neutralization of interleukin (IL)-6 in
Externí odkaz:
https://doaj.org/article/92c010c02ff34f8d808756182478a481
Autor:
Christian Vossen, Patricia Schmidt, Claudia Maria Wunderlich, Melanie Joyce Mittenbühler, Claas Tapken, Peter Wienand, Paul Nicolas Mirabella, Leonie Cabot, Anna-Lena Schumacher, Kat Folz-Donahue, Christian Kukat, Ingo Voigt, Jens C. Brüning, Henning Fenselau, F. Thomas Wunderlich
Publikováno v:
Cells, Vol 13, Iss 1, p 102 (2024)
Enteroendocrine cells (EECs) constitute only a small proportion of Villin-1 (Vil1)-expressing intestinal epithelial cells (IECs) of the gastrointestinal tract; yet, in sum, they build the largest endocrine organ of the body, with each of them storing
Externí odkaz:
https://doaj.org/article/eaf10d02ed844a188e6cca6ae65c46b1
Autor:
Eva-Maria Cox, Mohamed El-Behi, Stefanie Ries, Johannes F. Vogt, Vivien Kohlhaas, Thomas Michna, Benoît Manfroi, Mona Al-Maarri, Florian Wanke, Boaz Tirosh, Corinne Pondarre, Harry Lezeau, Nir Yogev, Romy Mittenzwei, Marc Descatoire, Sandra Weller, Jean-Claude Weill, Claude-Agnès Reynaud, Pierre Boudinot, Luc Jouneau, Stefan Tenzer, Ute Distler, Anne Rensing-Ehl, Christoph König, Julian Staniek, Marta Rizzi, Aude Magérus, Frederic Rieux-Laucat, F. Thomas Wunderlich, Nadine Hövelmeyer, Simon Fillatreau
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112378- (2023)
Summary: The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cel
Externí odkaz:
https://doaj.org/article/92cc14fd0e5540159395986a3869f5d7
Autor:
Hirofumi Nagao, Weikang Cai, Bruna B. Brandão, Nicolai J. Wewer Albrechtsen, Martin Steger, Arijeet K. Gattu, Hui Pan, Jonathan M. Dreyfuss, F. Thomas Wunderlich, Matthias Mann, C. Ronald Kahn
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here
Externí odkaz:
https://doaj.org/article/22ea319743b447ccb3e07487b07381ad
Autor:
Isabella Gaziano, Svenja Corneliussen, Nasim Biglari, René Neuhaus, Linyan Shen, Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J. De Solis, Weiyi Chen, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Dopamine acts on neurons in the arcuate nucleus (ARC) of the hypothalamus, which controls homeostatic feeding responses. Here we demonstrate a differential enrichment of dopamine receptor 1 (Drd1) expression in food intake–promoting agouti related
Externí odkaz:
https://doaj.org/article/04d46d9f4e164c19a1ca885f921b9383