Immunomodulation profile of the biosimilar trastuzumab MYL-1401O in a bioequivalence phase I study

Autor: R. Audran, H. Chtioui, A. C. Thierry, C. E. Mayor, L. Vallotton, K. Dao, L. E. Rothuizen, A. Maghraoui, E. J. Pennella, F. Brunner-Ferber, T. Buclin, F. Spertini

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract The initial Phase-I single centre, single dose, randomized, double-blind, cross-over study was planned to assess the pharmacokinetic and pharmacodynamic bioequivalence of the trastuzumab biosimilar (MYL-1401O) compared to the reference Herce

Externí odkaz: https://doaj.org/article/5a559ec5f6b549d9beb99f07224d0849

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Non-immediate drug hypersensitivity reactions secondary to intravitreal anti-vascular endothelial growth factors

Autor: C. Besse-Hayat, J. Bijon, Aude Ambresin, F. Spertini, D. Hohl, Christina Gianniou, E. Moret, S. Bogiatzi, Irmela Mantel

Publikováno v: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, vol. 260, no. 3, pp. 1005-1014

Purpose To describe a series of non-immediate drug hypersensitivity reactions after intravitreal anti-vascular endothelial growth factors (anti-VEGFs). Patients and methods Retrospective report of 6 patients with cutaneous non-immediate drug hypersen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529c6b5a977d8835c87d10ef0eb66245
https://pubmed.ncbi.nlm.nih.gov/34529134

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FRI0582 Open-label, multicenter, dose-escalating phase ii clinical trial on the safety and efficacy of tadekinig alpha in adult onset still's disease

Autor: C Gabay, B Fautrel, J Rech, F Spertini, E Feist, I Koetter, E Hachulla, J Morel, T Schaeverbeke, MA Hamidou, T Martin, B Hellmich, P Lamprecht, H Schultze-Koops, A Sleight, E Schiffrin

Publikováno v: Poster Presentations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7890d467247859265271b51e3e214f18
https://doi.org/10.1136/annrheumdis-2017-eular.2336