Zobrazeno 1 - 10
of 179
pro vyhledávání: '"F Sodoyez Goffaux"'
Autor:
F. Sodoyez-Goffaux, A. Beretta, Marina Scavini, F. Fazio, Guido Pozza, Nicoletta Dozio, Flaviano Dosio, C. Belloni, E. Sarugeri, A. Savi
Publikováno v:
Scopus-Elsevier
Background Insulin receptor antibodies can induce severe hypoglycemia or insulin resistance in rare autoimmune syndromes. In vitro properties of these antibodies occasionally explain the clinical features of the syndrome, but direct evidence of their
Autor:
B Dinesen, F. Sodoyez-Goffaux, Bruce H. Frank, Chris Van Schravendijk, Paule Houssa, Michelle Deberg, J. C. Sodoyez
Publikováno v:
Clinical Chemistry. 44:1514-1519
We describe a sensitive two-site sandwich enzyme-linked immunosorbent assay for the measurement of intact human proinsulin in 100 μL of serum or plasma. The assay is based on the use of two monoclonal antibodies specific for epitopes at the C-peptid
Publikováno v:
Clinical Chemistry. 44:1504-1513
We describe a rapid and simple insulin RIA in which proinsulin and conversion intermediates do not interfere. Three monoclonal antibodies (S1, S2, and S53) were selected for their specificity (directed, respectively, against the B10 region, the junct
Publikováno v:
Diabetes Research and Clinical Practice. 21:19-24
To evaluate the immunization pattern against human insulin, 24 newly diagnosed diabetic children (12 females, 12 males; mean age: 7 +/- 4 years) were treated from diagnosis onwards with semisynthetic human insulin (NOVO). Informed consent was obtaine
Publikováno v:
Clinical and Experimental Immunology. 85:282-287
SUMMARYInsulin antibodies in six patients with immune hypoglycaemic syndrome were studied. The antibodies displayed a higher affinity for bovine insulin in two patients, were specific for human insulin in one patient and non-species specific in the o
Autor:
I. Lemaire, F. Sodoyez-Goffaux, A. Rapaille, C. François-Gérard, M. Koch, J. C. Sodoyez, D. Sondag
Publikováno v:
Diabetologia. 34:463-468
Hybridomas producing proinsulin antibodies were cloned by limiting dilution of cell cultures obtained by fusion of splenocytes of immunized mice with immortal myeloma cells. Some proinsulin monoclonal antibodies crossreacted with labelled insulin but
Autor:
Emanuele Bosi, C. Bouillenne, M. Koch, C. François-Gérard, F. Sodoyez-Goffaux, D. Sondag, J. C. Sodoyez
Publikováno v:
Diabetologia. 33:719-725
Serum samples of 2200 blood donors were screened for anti-insulin IgG by enzyme-linked immunosorbent assay. Specificity of detected antibodies was verified by competition with an excess of insulin and observation that saturated anti-insulin IgG were
Intact proinsulin and beta-cell function in lean and obese subjects with and without type 2 diabetes
Autor:
Michael E Røder, Christian Binder, B Dinesen, F. Sodoyez-Goffaux, P Houssa, Henrik Vestergaard, Svend G Hartling
Publikováno v:
University of Copenhagen
OBJECTIVE: Type 2 diabetes is a heterogeneous disease in which both beta-cell dysfunction and insulin resistance are pathogenetic factors. Disproportionate hyperproinsulinemia (elevated proinsulin/insulin) is another abnormality in type 2 diabetes wh
Publikováno v:
Clinical chemistry. 44(7)
We describe a rapid and simple insulin RIA in which proinsulin and conversion intermediates do not interfere. Three monoclonal antibodies (S1, S2, and S53) were selected for their specificity (directed, respectively, against the B10 region, the junct
Autor:
P, Houssa, B, Dinesen, M, Deberg, B H, Frank, C, Van Schravendijk, F, Sodoyez-Goffaux, J C, Sodoyez
Publikováno v:
Clinical chemistry. 44(7)
We describe a sensitive two-site sandwich enzyme-linked immunosorbent assay for the measurement of intact human proinsulin in 100 microL of serum or plasma. The assay is based on the use of two monoclonal antibodies specific for epitopes at the C-pep