Zobrazeno 1 - 10
of 333
pro vyhledávání: '"F S Abbott"'
Publikováno v:
The Pharmacogenomics Journal. 3:335-342
The present study investigated the effect of cytochrome P450 2C9 (CYP2C9) genetic polymorphism on the biotransformation of valproic acid (VPA) to its hepatotoxic metabolite, 4-ene-VPA, and compared that to the formation of the inactive 4-OH-VPA and 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9708044c8df11d0ac0e226d84b154ec
https://doi.org/10.1038/sj.tpj.6500210
https://doi.org/10.1038/sj.tpj.6500210
Publikováno v:
Drug Metabolism and Disposition. 31:114-121
In this study, spectroscopic and chromatographic evidence is presented for the identification and characterization of the metabolites, valproyl glutamate (2-propylpentanoyl glutamate, VPA-GLU) and valproyl glutamine (2-propylpentanoyl glutamine, VPA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8134e49924a7fc5557b4f410fb64d20
https://doi.org/10.1124/dmd.31.1.114
https://doi.org/10.1124/dmd.31.1.114
Autor:
A Acheampong, F S Abbott
Publikováno v:
Journal of Lipid Research, Vol 26, Iss 8, Pp 1002-1008 (1985)
Valproic acid, an antiepileptic drug, is transformed into diunsaturated metabolites in humans. Synthesis of the geometric isomers of 2-(1'-propenyl)-2-pentenoic acid and 2-(1'-propenyl)-3-pentenoic acid was attempted using known procedures. The final
Externí odkaz:
https://doaj.org/article/ce0e1c1fc0ed443696952b13b59e1ca2
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
Dose-dependent pharmacokinetics and metabolism of valproic acid (VPA) were studied in newborn and adult sheep to assess age-related differences in plasma protein binding and metabolic elimination. Newborn lambs received either a 10- (n = 8), 50- (n =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29d93e79e208e70e2073214e6c221276
https://pubmed.ncbi.nlm.nih.gov/11302932
https://pubmed.ncbi.nlm.nih.gov/11302932
Publikováno v:
Journal of pharmacypharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 4(1)
The hepatic extraction of a novel antiarrhythmic, RSD1070, was investigated to test the hypothesis that the poor bioavailability observed in rats is due to high hepatic metabolism.The pharmacokinetics of RSD1070 was examined in rats (n=8) and its met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55f806253ae9e92e93fdc8964e820099
https://pubmed.ncbi.nlm.nih.gov/11302786
https://pubmed.ncbi.nlm.nih.gov/11302786
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(8)
The ontogeny of valproic acid (VPA) disposition and metabolism was investigated in developing lambs and adult sheep (Dorset or Suffolk breed). Specifically, we wished to investigate the role of glucuronidation and beta-oxidation on VPA elimination du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14ffc9f6175f20b52d549bbdb4d3c668
https://pubmed.ncbi.nlm.nih.gov/10901700
https://pubmed.ncbi.nlm.nih.gov/10901700
Publikováno v:
Journal of mass spectrometry : JMS. 35(6)
We report a GC/NICI-MS assay and a LC/ESI-MS/MS assay for the analysis of N-acetylcysteine (NAC) conjugates of (E)-2,4-diene VPA (NAC I and NAC II) identified in humans. The assay also includes the analysis of the NAC conjugate of 4,5-epoxy VPA (NAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64f0d6b9633fb5d372018f6ff9b7f7dd
https://pubmed.ncbi.nlm.nih.gov/10862121
https://pubmed.ncbi.nlm.nih.gov/10862121
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(7)
Reactive and hepatotoxic metabolites formed from the biotransformation of valproic acid (VPA) are normally detoxified by conjugating with GSH and followed by mercapturic acid metabolism to produce their respective N-acetylcysteine (NAC) conjugates. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b68408f6d18651b9e1a73ff8d376005
https://pubmed.ncbi.nlm.nih.gov/10859157
https://pubmed.ncbi.nlm.nih.gov/10859157
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(7)
Metabolism and renal excretion of valproic acid (VPA) were examined in maternal, fetal, and newborn sheep to identify the underlying reasons for the previously observed reduced VPA clearance in newborn lambs. Plasma and urine from VPA infusion studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::041195c06e5c5976687134d3ad141b77
https://pubmed.ncbi.nlm.nih.gov/10859160
https://pubmed.ncbi.nlm.nih.gov/10859160
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(7)
Separate 24-h maternal and fetal infusions of valproic acid (VPA) were administered to five pregnant sheep at 125 to 138 days gestation (term approximately 145 days) to determine maternal-fetal disposition. The pharmacokinetics of VPA were also inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d4daaae5af8380a6a05179c70515773
https://pubmed.ncbi.nlm.nih.gov/10859159
https://pubmed.ncbi.nlm.nih.gov/10859159