Výsledky vyhledávání - "F S, Markland"

Resolution of Isoforms of Natural and Recombinant Fibrinolytic Snake Venom Enzyme Using High Performance Capillary Electrophoresis

Autor: Keith B. Ward, F. S. Markland, Jeffrey R. Deschamps, S. Morris

Publikováno v: Journal of Liquid Chromatography. 16:2189-2201

Prior studies have indicated that highly purified samples of natural fibrolase. a fibrinolytic metalloproteinase from southern copperhead snake venom, contains two isoforms. The isoelectric points of these isoforms differ by 0.01 to 0.03 pH units. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dbdd3d436a8f8a2d53623c1d6fe4552
https://doi.org/10.1080/10826079308019923

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Alpha-fibrinogenases

Autor: S, Swenson, C F, Toombs, L, Pena, J, Johansson, F S, Markland

Publikováno v: Current drug targets. Cardiovascularhaematological disorders. 4(4)

Snake venoms contain a number of serine and metalloproteinases, included among these are the fibrinolytic metalloproteinases. When the fibrinolytic enzymes were first isolated from viper venoms it was postulated that there may be a clinical applicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a5f1865f2b4fe4c8a7a2d0552e5e0f5
https://pubmed.ncbi.nlm.nih.gov/15578961

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Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis

Autor: Q, Zhou, M T, Nakada, C, Arnold, K Y, Shieh, F S, Markland

Publikováno v: Angiogenesis. 3(3)

Contortrostatin, a 13.5 kDa disulfide-linked homodimeric polypeptide possessing an Arg-Gly-Asp sequence, was isolated from venom of the southern copperhead snake. Daily injection of contortrostatin into the primary tumor of human breast cancer MDA-MB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5c47666e5551b0dda56d7f2d4ed2fb2
https://pubmed.ncbi.nlm.nih.gov/14517425

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Anti-invasive effect of contortrostatin, a snake venom disintegrin, and TNF-alpha on malignant glioma cells

Autor: S, Schmitmeier, F S, Markland, T C, Chen

Publikováno v: Anticancer research. 20(6B)

The snake venom disintegrin contortrostatin has been shown to bind to integrins alpha IIb beta 3, alpha v beta 3, alpha v beta 5, and alpha 5 beta 1 and to exert an anti-tumor activity in vitro and in vivo. The cytokine TNF-alpha has been demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00985964ff658a216de1704a9d9589b3
https://pubmed.ncbi.nlm.nih.gov/11205252

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Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression

Autor: Q, Zhou, R P, Sherwin, C, Parrish, V, Richters, S G, Groshen, D, Tsao-Wei, F S, Markland

Publikováno v: Breast cancer research and treatment. 61(3)

We report the results of a multidisciplinary study on the inhibitory effect of a snake venom disintegrin, contortrostatin, a 13.5 kDa homodimeric protein isolated from Agkistrodon contortrix contortrix (southern copperhead) venom, on breast cancer pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34896b07c5b1aa0efb4b72f579aa39c5
https://pubmed.ncbi.nlm.nih.gov/10966001

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Contortrostatin, a snake venom disintegrin, induces alphavbeta3-mediated tyrosine phosphorylation of CAS and FAK in tumor cells

Autor: M R, Ritter, Q, Zhou, F S, Markland

Publikováno v: Journal of cellular biochemistry. 79(1)

Contortrostatin is a homodimeric disintegrin that inhibits platelet aggregation and cell adhesion to extracellular matrix proteins by blocking integrins. The effect of contortrostatin on integrin-mediated signaling in tumor cells was investigated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84245eef6684b275d7e915813f765136
https://pubmed.ncbi.nlm.nih.gov/10906753

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Snake venom fibrinogenolytic and fibrinolytic enzymes: an updated inventory. Registry of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis

Autor: F S, Markland

Publikováno v: Thrombosis and haemostasis. 79(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af55a6161a5eb235fa54ed96a28c1460
https://pubmed.ncbi.nlm.nih.gov/9531060

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Contortrostatin, a snake venom disintegrin, inhibits beta 1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis

Autor: M, Trikha, Y A, De Clerck, F S, Markland

Publikováno v: Cancer research. 54(18)

Disintegrins are Arg-Gly-Asp-containing proteins that inhibit integrin-mediated cell-cell and cell-matrix interactions. We have purified a disintegrin, contortrostatin, from Agkistrodon contortrix contortrix snake venom that is a potent inhibitor of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2bd4d0bbee57f7dd089c541a009979f
https://pubmed.ncbi.nlm.nih.gov/7520832

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