Zobrazeno 1 - 10
of 13
pro vyhledávání: '"F S, Kittrell"'
Publikováno v:
Ernst Schering Foundation symposium proceedings. (1)
Estrogen and progesterone play a critical role in normal and neoplastic development of the mammary gland. A long duration of estrogen and progesterone exposure is associated with increased breast cancer risk, and a short duration of the same doses of
Publikováno v:
Cancer research. 61(18)
Maspin is a unique serine protease inhibitor of which the down-regulation is associated with the development of breast cancers. In vitro, recombinant maspin inhibits tumor cell migration and invasion. Overexpression of maspin in transgenic mice is pr
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 12(6)
The level of circulating ovarian hormones (estrogen and progesterone) alone or in combination with pituitary hormones have a potent mitogenic impact in the normal mammary gland, and they also play a pivotal role in the development and progression of
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 14(14)
Mammary epithelial cells from p53 null mice have been shown recently to exhibit an increased risk for tumor development. Hormonal stimulation markedly increased tumor development in p53 null mammary cells. Here we demonstrate that mammary tumors aris
Publikováno v:
Cancer research. 59(17)
To define the functional relevance of progesterone-initiated intracellular signaling in mammary gland tumorigenesis, the progesterone receptor knockout (PRKO) mouse model was used in the context of an established carcinogen-induced mammary tumorigene
Publikováno v:
Cancer research. 53(7)
Breast cancer is a consequence of multiple alterations occurring over a long period of time. Genetic changes in early stages of tumorigenesis have not been defined. A recently developed murine system permits the study of mammary preneoplastic cells i
Publikováno v:
Cancer research. 53(3)
The TM preneoplastic mammary outgrowth lines were established in vivo from mammary epithelial cell lines and have been characterized with respect to their tumorigenic, morphological, and functional properties. The TM outgrowth lines were then establi
Publikováno v:
Cancer research. 53(3)
The TM series of preneoplastic mammary outgrowth lines was derived from the transplantation of the FSK mammary cell lines into the cleared mammary fat pads of syngeneic female BALB/c mice. The tumor-producing capabilities of the 6 TM outgrowth lines
Autor:
B M, Markaverich, T H, Schauweker, R R, Gregory, M, Varma, F S, Kittrell, D, Medina, R S, Varma
Publikováno v:
Cancer research. 52(9)
Methyl-p-hydroxyphenyllactate (MeHPLA) is a bioflavonoid and/or tyrosine metabolite which may regulate cellular growth and proliferation through interactions with nuclear type II sites. Our current studies suggest that type II sites may function as M
Publikováno v:
Cancer research. 52(7)
A series of mouse mammary epithelial cell lines has been established by a protocol that gives highly reproducible results. The mammary epithelial cell lines, designated as FSK lines, were judged to be epithelial based on positive immunostaining for k