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Akademický článek

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway.

Autor: Jeffrey M Hollomon, Zhongle Liu, Scott F Rusin, Nicole P Jenkins, Allia K Smith, Katja Koeppen, Arminja N Kettenbach, Lawrence C Myers, Deborah A Hogan

Publikováno v: PLoS Genetics, Vol 18, Iss 1, p e1009622 (2022)

Ssn3, also known as Cdk8, is a member of the four protein Cdk8 submodule within the multi-subunit Mediator complex involved in the co-regulation of transcription. In Candida albicans, the loss of Ssn3 kinase activity affects multiple phenotypes inclu

Externí odkaz: https://doaj.org/article/54bd89527e8c488da2f49df4c9139036

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Akademický článek

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

Autor: Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter

Publikováno v: eLife, Vol 9 (2020)

Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is poorly characterized, especially in higher eukaryotes, with the major

Externí odkaz: https://doaj.org/article/f28d705b3f05490b91c7e479d58b568b

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Akademický článek

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Inducible protein degradation as a strategy to identify Phosphoprotein Phosphatase 6 substrates in RAS-mutant colorectal cancer cells

Autor: Natasha C. Mariano, Scott F. Rusin, Isha Nasa, Arminja N. Kettenbach

Publikováno v: bioRxiv

Protein phosphorylation is an essential regulatory mechanism that controls most cellular processes, including cell cycle progression, cell division, and response to extracellular stimuli, among many others, and is deregulated in many diseases. Protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600b9aa59797ed30000748d0f0c92d31
https://europepmc.org/articles/PMC10055397/

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Akademický článek

Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics

Autor: Scott F. Rusin, Mark E. Adamo, Arminja N. Kettenbach

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 5 (2017)

Protein phosphorylation is a crucial regulatory mechanism that controls many aspects of cellular signaling. Casein kinase 2 (CK2), a constitutively expressed and active kinase, plays key roles in an array of cellular events including transcription an

Externí odkaz: https://doaj.org/article/e4c986185e5f4400a98135ad70bb330d

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Akademický článek

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

Autor: Ana Maria G Dumitru, Scott F Rusin, Amber E M Clark, Arminja N Kettenbach, Duane A Compton

Publikováno v: eLife, Vol 6 (2017)

The fidelity of chromosome segregation in mitosis is safeguarded by the precise regulation of kinetochore microtubule (k-MT) attachment stability. Previously, we demonstrated that Cyclin A/Cdk1 destabilizes k-MT attachments to promote faithful chromo

Externí odkaz: https://doaj.org/article/ccbb4531ee054d55a04a4b47cd938ba7

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