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Synthesis and anti-arthritic activity of a series of 1-aryl-3-dimethylamino-1,4-dihydroisoquinolines

Autor: Jose Bermudez, F. R. Mangan, P. A. Wyman, Thomson Michael John, Roger Edward Markwell, Ian Hughes, Eric H. Karran, Stephen A. Smith

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2571-2576

1-Aryl-3-dimethylamino-1,4-dihydroisoquinoline ( 1 ) were synthesised from 1-aryl-1,4-dihydroisoquinol-3-ones ( 2 ) by heating in dimethylcarbamyl chloride. Compounds bearing electron withdrawing substituents on the 1-aryl ring were active in inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::882adcc16bd28d318bed0b4b106645e0
https://doi.org/10.1016/s0960-894x(01)80718-6

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ChemInform Abstract: Synthesis and Anti-Arthritic Activity of a Series of 1-Aryl-3- dimethylamino-1,4-dihydroisoquinolines

Autor: Thomson Michael John, Jose Bermudez, Roger Edward Markwell, Stephen A. Smith, F. R. Mangan, P. A. Wyman, Ian Hughes, Eric H. Karran

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::456f61a41593bab82e65634c43f79e0f
https://doi.org/10.1002/chin.199427148

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Fourth European Workshop on Inflammation Wilrijk March 1982

Autor: B. Dewald, J. G. R. Elferink, D. Gemsa, M. Kazatchkine, E. Jellum, M. Cremer, J. Winkelmann, Jozef Vermylen, F. Maillet, D. G. Wickens, C. M. Willis, A. G. Herman, S. Leyck, H. Bult, M. Baggiolini, W. Paul, E. Alesse, K. Brune, E. L. Mehler, T. Appelboom, T. L. Dormandy, G. M. Laekeman, R. Görtz, K. Joop, G. Doekes, A. Timmermans, M. Fagerhol, H. P. Hartwig, L. Drummond, H. U. Gubler, D. K. Gemmell, J. E. Vincent, E. H. Karran, E. Etschenberg, M. Pierart, R. J. T. Ouwendijk, A. Sturk, A. Herchuelz, E. Fischer, M. J. Parnham, M. H. Jouvin, J. Reuse, A. J. M. Schreurs, F. R. Mangan, J. C. Riemersma, F. P. Nijkamp, Ch. Gillebert, P. Henricks, E. Stolz, C. Lakatos, C. F. Moldow, F. Nijkamp, F. Bussolino, L. L. M. Thomas, M. Pelletier, P. U. Angeletti, G. Deby-Dupont, J. Morley, K. Willard, M. Delronche, T. Payne, C. Tetta, J. W. ten Cate, M. Guillaume, D. Bitter-Suermann, J. L. Junien, C. Deby, H. ten Cate, G. Emanuelli, F. J. Zijlstra, I. L. Bonta, G. R. Elliott, J. H. P. Wilson, J. P. Giroud, H. R. Büller, P. A. Henricks, E. S. Kalter, J. Verhoef, G. Montrocchio, C. Antro, L. A. van Es, R. Verwilghen, M. J. P. Adolfs, C. P. Page, G. Ianni, A. P. Green, U. Hadding, H. P. Hartung, J. Habicht, G. Camussi, H. Deckmyn, A. Weyns, H. Siegl, B. N. Bouma, A. Van Gossum, C. Lambré, E. Schrauwen, P. G. Robins, E. Munthe, M. A. Continenza, M. R. Daha, A. Houvenaghel, J. Fontaine, M. G. Cifone, W. C. van Dijk, K. D. Rainsford, M. A. Boogaerts, H. Ott, Jean Pierre Famaey, M. Rampart, P. Conti

Publikováno v: Clinical Rheumatology. 1:140-152

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37cc6d0706c6e4da0c4967f4f3fa7209
https://doi.org/10.1007/bf02275607

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The effect of anti-inflammatory and anti-rheumatic drugs on cell accumulation onto nitrocellulose discs implanted subcutaneously into mice

Autor: A. P. Green, F. R. Mangan

Publikováno v: Agents and Actions. 13:368-372

Nitrocellulose discs were implanted subcutaneously into mice and cell accumulation measured 96 hours later. Cell accumulation was inhibited by the anti-inflammatory steroids hydrocortisone, dexamethasone and triamcinolone acetonide, but higher doses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceafffe41ea319b1a3d59dd5600b5f37
https://doi.org/10.1007/bf01971491

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7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents

Autor: Elizabeth A. Boyle, F. R. Mangan, Thomson Michael John, P. A. Wyman, Roger Edward Markwell, Robert William Ward, Stephen A. Smith

Publikováno v: Journal of Medicinal Chemistry. 29:894-898

The synthesis of a series of 7-aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids is described. The isomeric 4-benzoyl-1,3-dihydrobenzo[c]furan-1-carboxylic acid was also prepared. Compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e062237ffccaa9872bd492f12da041f2
https://doi.org/10.1021/jm00156a004

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Specific changes in the messenger ribonucleic acid content of the rat ventral prostate gland after androgenic stimulation. Evidence from the synthesis of aldolase messenger ribonucleic acid

Autor: D A Jones, W. I. P. Mainwaring, R A Irving, F R Mangan

Publikováno v: Biochemical Journal. 144:413-426

1. Aldolase was selected as a suitable marker for following the androgenic regulation of mRNA synthesis in the prostate gland. 2. Antibodies raised in rabbits against crystalline prostate aldolase were used to monitor the synthesis of this androgen-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8e8c011606b8a07e3f754c83092b38
https://doi.org/10.1042/bj1440413

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BRL 20459, a novel topically active non-steroidal anti-inflammatory drug

Autor: A. P. Green, K E Randall, F. R. Mangan, M. J. Thomson, E. A. Boyle

Publikováno v: Journal of Pharmacy and Pharmacology. 36:314-317

BRL 20459 is a novel compound which displays anti-inflammatory activity when applied topically in the croton oil and cantharadin rat ear inflammation models. The compound does not inhibit uv-induced erythema in the guinea-pig or granuloma formation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dc62ff03ec815949a1605f9dc46949
https://doi.org/10.1111/j.2042-7158.1984.tb04381.x

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The effect of a novel, non-steroidal anti-inflammatory compound, nabumetone (BRL 14777), on cellular infiltration into 24-hour polyvinyl sponge implants in the rat, compared with some steroidal and nonsteroidal anti-inflammatory drugs

Autor: Elizabeth A. Boyle, F. R. Mangan

Publikováno v: Journal of Pharmacy and Pharmacology. 34:570-575

The time-course of cell migration into saline-soaked sponge implants over 5 days showed peak polymorphonuclear leucocyte (PMNL) infiltration at 24 h. In common with the corticosteroids dexamethasone and hydrocortisone, and the non-steroidal anti-infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7219f8e8db30f511b24ec265bec35938
https://doi.org/10.1111/j.2042-7158.1982.tb04795.x

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Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent

Autor: P. C. Freemanm, F. R. Mangan, E. A. Boyle, M. J. Thomson

Publikováno v: Journal of Pharmacy and Pharmacology. 34:562-569

Nabumetone is a compound of novel structure which displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs. Its activity in these tests is greater than that of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6820c3beaff6177381820140ec95e98
https://doi.org/10.1111/j.2042-7158.1982.tb04794.x

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Penetration of nabumetone into inflammatory exudates in the rat

Autor: D J Jeffery, F R Mangan, R E Haddock, I S Pardon

Publikováno v: Journal of Pharmacy and Pharmacology. 35:358-362

The penetration of radioactivity into inflamed sites induced by subcutaneously implanted cotton pellets was studied in the rat after oral administration of [14C]nabumetone. Equilibration between inflamed site and plasma concentrations was slow, maxim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa7051763f6f54bdc4a6b3b907eb0e3
https://doi.org/10.1111/j.2042-7158.1983.tb02956.x

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