Výsledky vyhledávání

Chronic myelomonocytic leukaemia after platinum-based therapy for non-small cell lung cancer: case report and review of the literature

Autor: K. B. Kim, S. Faderl, C. S. Hwang, F. R. Khuri

Publikováno v: Journal of Clinical Pharmacy and Therapeutics. 31:401-406

Summary Chronic myelomonocytic leukaemia (CMML) is a preleukaemic condition with myeloproliferative features, and classified as a part of myelodysplastic syndrome (MDS). Other than alkylating agents and topoisomerase II inhibitors, there is less evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc60279e7d610eeead5241381dbf7d4
https://doi.org/10.1111/j.1365-2710.2006.00748.x

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Farnesyl transferase inhibitors: the next targeted therapies for breast cancer?

Autor: F R Khuri, R M O'Regan

Publikováno v: Endocrine-related cancer. 11(2)

The ras family of proto-oncogenes are upstream mediators of several essential cellular signal transduction pathways involved in cell proliferation and survival. Point mutations of ras oncogenes result in constitutively active Ras and have been shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db20acaa4706fc9f52de8dd61149568e
https://pubmed.ncbi.nlm.nih.gov/15163298

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Phase II study of the antiangiogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck

Autor: J E, Tseng, B S, Glisson, F R, Khuri, D M, Shin, J N, Myers, A K, El-Naggar, J S, Roach, L E, Ginsberg, P F, Thall, X, Wang, S, Teddy, K N, Lawhorn, R E, Zentgraf, G D, Steinhaus, J M, Pluda, J L, Abbruzzese, W K, Hong, R S, Herbst

Publikováno v: Cancer. 92(9)

Thalidomide has been shown to have antiangiogenic effects in preclinical models as well as a significant antitumor effect in hematologic tumors such as multiple myeloma. The authors performed this Phase II study to determine the activity, toxicity pr

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https://pubmed.ncbi.nlm.nih.gov/11745292

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The impact of smoking status, disease stage, and index tumor site on second primary tumor incidence and tumor recurrence in the head and neck retinoid chemoprevention trial

Autor: F R, Khuri, E S, Kim, J J, Lee, R J, Winn, S E, Benner, S M, Lippman, K K, Fu, J S, Cooper, E E, Vokes, R M, Chamberlain, B, Williams, T F, Pajak, H, Goepfert, W K, Hong

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(8)

Second primary tumors (SPTs) develop at an annual rate of 3-7% in patients with head and neck squamous cell cancer (HNSCC). In a previous Phase III study, we observed that high doses of 13-cis-retinoic acid reduced the SPT rate in this disease. In 19

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https://pubmed.ncbi.nlm.nih.gov/11489748

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Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer

Autor: D M, Shin, N J, Donato, R, Perez-Soler, H J, Shin, J Y, Wu, P, Zhang, K, Lawhorn, F R, Khuri, B S, Glisson, J, Myers, G, Clayman, D, Pfister, J, Falcey, H, Waksal, J, Mendelsohn, W K, Hong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(5)

C225, a human-mouse chimerized monoclonal antibody directed against the epidermal growth factor receptor (EGFr), has a synergistic effect with cisplatin in xenograft models. To determine the tumor EGFr saturation dose with C225 and the fate of infuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4684c649ce32a7c3eaebf743d3c0112e
https://pubmed.ncbi.nlm.nih.gov/11350885

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Modulation of proliferating cell nuclear antigen in the bronchial epithelium of smokers

Autor: F R, Khuri, J S, Lee, S M, Lippman, J J, Lee, S, Kalapurakal, R, Yu, J Y, Ro, R C, Morice, W K, Hong, W N, Hittelman

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(4)

Clinical chemoprevention trials seek to intervene in the carcinogenic process to suppress, reverse, or delay the development of invasive cancer. Dysregulated cell growth is a hallmark of epithelial carcinogenesis, and proliferating cell nuclear antig

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https://pubmed.ncbi.nlm.nih.gov/11319170

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Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer

Autor: F R, Khuri, H, Wu, J J, Lee, B L, Kemp, R, Lotan, S M, Lippman, L, Feng, W K, Hong, X C, Xu

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(4)

Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to prostaglandins, is overexpressed in a variety of different tumors, including those of the colon, pancreas, lung, and head and neck. We used in situ hybridization with a digoxgenin

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https://pubmed.ncbi.nlm.nih.gov/11309334

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Prevention of lung cancer. The new millennium

Autor: E S, Kim, W K, Hong, F R, Khuri

Publikováno v: Chest surgery clinics of North America. 10(4)

Lung cancer is the leading cause of cancer-related death worldwide and in the United States surpassing breast, prostate, and colon cancer. Treatment of this disease over the past 2 decades has advanced incrementally as survival rates have improved on

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https://pubmed.ncbi.nlm.nih.gov/11091919

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N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium

Autor: J M, Kurie, J S, Lee, F R, Khuri, L, Mao, R C, Morice, J J, Lee, G L, Walsh, A, Broxson, S M, Lippman, J Y, Ro, B L, Kemp, D, Liu, H A, Fritsche, X, Xu, R, Lotan, W K, Hong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)

Lung cancer remains the number one cause of cancer-related deaths in the United States. To reduce the mortality associated with this disease, individuals at risk must be identified prior to the development of lung cancer, and effective prevention str

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https://pubmed.ncbi.nlm.nih.gov/10955773

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Treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck: current status and future directions

Autor: F R, Khuri, D M, Shin, B S, Glisson, S M, Lippman, W K, Hong

Publikováno v: Seminars in oncology. 27(4 Suppl 8)

Patients with advanced squamous cell head and neck cancer have a dismal long-term survival rate not only because of metastatic disease, but also primarily because of failure in local disease control. The role of chemotherapy in recurrent or metastati

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https://pubmed.ncbi.nlm.nih.gov/10952435

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