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pro vyhledávání: '"F R, Rose"'
Autor:
D, Kaur, E, Gomez, C, Doe, R, Berair, L, Woodman, R, Saunders, F, Hollins, F R, Rose, Y, Amrani, R, May, J, Kearley, A, Humbles, E S, Cohen, C E, Brightling
Publikováno v:
Allergy
Background Mast cell localization within the airway smooth muscle (ASM)-bundle plays an important role in the development of airway hyper-responsiveness (AHR). Genomewide association studies implicate the ‘alarmin’ IL-33 in asthma, but its role i
Publikováno v:
The Journal of Experimental Medicine
We have previously (1-4) demonstrated that adenosine, by engaging specific receptors on the surface of neutrophils, inhibits generation of toxic oxygen metabolites by activated neutrophils and prevents these activated neutrophils from injuring endoth
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 987:176-180
At inflammatory sites neutrophils are stimulated to produce a variety of toxic agents, yet rarely harm the endothelium across which they migrate. We have recently found that endothelium releases adenosine which, acting via receptors on the surface of