Zobrazeno 1 - 10
of 19
pro vyhledávání: '"F R, Jirik"'
Autor:
J van der Kaa, G J Platenburg, J D Leung, F R Pieper, D O Co, S Hengst, Anita Borowski, F R Jirik, Carl Perez, J I Drayer
Publikováno v:
Chromosome Research. 8:183-191
We have generated transgenic mice by pronuclear microinjection of a murine satellite DNA-based artificial chromosome (SATAC). As 50% of the founder progeny were SATAC-positive, this demonstrates that SATAC transmission through the germline had occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c58a298ee7a46ebf48e5498066a25c97
https://doi.org/10.1023/a:1009206926548
https://doi.org/10.1023/a:1009206926548
Publikováno v:
Annals of the New York Academy of Sciences. 557:509-511
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7200d9b5fcc65218a7b68de4d496d32f
https://doi.org/10.1111/j.1749-6632.1989.tb24048.x
https://doi.org/10.1111/j.1749-6632.1989.tb24048.x
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 24(9)
Cellular prion protein (PrP(C) ) is expressed in the enteric nervous system (ENS), however, its physiological role has not been identified. Studies suggest that PrP(C) can function as a metal-binding protein, as absence of the protein has been linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5ab7c287a88b110af0ce5989a4181ed
https://pubmed.ncbi.nlm.nih.gov/22762267
https://pubmed.ncbi.nlm.nih.gov/22762267
Publikováno v:
Evolutiondevelopment. 9(1)
Understanding the developmental and genetic basis for evolutionarily significant morphological variation in complex phenotypes such as the mammalian skull is a challenge because of the sheer complexity of the factors involved. We hypothesize that eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e25860642f5db3620e976862b1953003
https://pubmed.ncbi.nlm.nih.gov/17227368
https://pubmed.ncbi.nlm.nih.gov/17227368
Autor:
J. L. Moody, F. R. Jirik
Publikováno v:
Immunology. 112(3)
Tight regulation of the phosphatidylinositiol 3-kinase (P13K) pathway is essential not only for normal immune system development and responsiveness, but also in the prevention of immunopathology. Indeed, unchecked activation of the PI3K pathway in T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ca41cd3249751491ebc76c3d4d8fd5
https://pubmed.ncbi.nlm.nih.gov/15196208
https://pubmed.ncbi.nlm.nih.gov/15196208
Publikováno v:
Genes and immunity. 4(1)
Phosphatidylinositol 3-kinase (PI3K) has emerged as a critical component of multiple immune system intracellular signalling pathways. The levels and relative ratios of PI3K products, phosphatidylinositol (3,4) bisphosphate (PI(3,4)P(2)) and phosphati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8ac18cbb2c57abb23ec8579be60b01
https://pubmed.ncbi.nlm.nih.gov/12595903
https://pubmed.ncbi.nlm.nih.gov/12595903
Publikováno v:
European journal of immunology. 31(8)
The ability of specific virally encoded proteins to down-regulate MHC class I molecules may enable infected cells to elude killing by CTL. In the case of HIV-1, Nef appears to be responsible for this effect. Thus, interfering with Nef-induced MHC cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d426bb7afcc4a848891aedea0cbfbc86
https://pubmed.ncbi.nlm.nih.gov/11500821
https://pubmed.ncbi.nlm.nih.gov/11500821
Autor:
S E, Andrew, X S, Xu, A, Baross-Francis, L, Narayanan, K, Milhausen, R M, Liskay, F R, Jirik, P M, Glazer
Publikováno v:
Carcinogenesis. 21(7)
DNA mismatch repair (MMR) deficiency leads to an increased mutation frequency and a predisposition to neoplasia. 'Knockout' mice deficient in the MMR proteins Msh2 and Pms2 crossed with mutation detection reporter (supF, lacI and cII) transgenic mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52db97e3c39570e063c778ec7accaada
https://pubmed.ncbi.nlm.nih.gov/10874005
https://pubmed.ncbi.nlm.nih.gov/10874005
Autor:
D O, Co, A H, Borowski, J D, Leung, J, van der Kaa, S, Hengst, G J, Platenburg, F R, Pieper, C F, Perez, F R, Jirik, J I, Drayer
Publikováno v:
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 8(3)
We have generated transgenic mice by pronuclear microinjection of a murine satellite DNA-based artificial chromosome (SATAC). As 50% of the founder progeny were SATAC-positive, this demonstrates that SATAC transmission through the germline had occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f7da0a21a69edb754e2dcda16203e2a
https://pubmed.ncbi.nlm.nih.gov/10841045
https://pubmed.ncbi.nlm.nih.gov/10841045
Publikováno v:
Carcinogenesis. 21(6)
We reported previously that thymic lymphomas arising in mice lacking the DNA mismatch repair (MMR) gene, Msh2(-/-), exhibited striking elevations in the mutation frequency of a transgenic lacI reporter gene when compared with normal Msh2(-/-) tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1baa04dbeed842226b1c037b3040b120
https://pubmed.ncbi.nlm.nih.gov/10837019
https://pubmed.ncbi.nlm.nih.gov/10837019