Výsledky vyhledávání

Immunohistochemical and molecular analyses of HER2 status in breast cancers are highly concordant and complementary approaches

Autor: Hany Soliman, Sylvie Giacchetti, Jacqueline Lehmann-Che, E. Bourstyn, Luc Legrès, Elisabeth Turpin, F Amira-Bouhidel, Philippe Bertheau, Marc Espié, A de Roquancourt, C. de Bazelaire, L-F Plassa, Martine Antoine, E Flandre, Mariana Varna, R Bernoud, C Bocquet, Laurence Cahen-Doidy, Anne Janin

Publikováno v: British Journal of Cancer

Background: Immunohistochemistry (IHC) and fluorescent in situ hybridisation (FISH) are currently the most commonly used methods to assess HER2 status. PCR-based assays allow quantitative determination of HER2 amplification (Q-PCR) or overexpression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2614be00c272543b3148260961c34971
http://europepmc.org/articles/PMC3111154

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Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma

Autor: Patrice Carde, Ali G. Turhan, Eric Deutsch, E Wittmer, A. L. Bennaceur, Françoise Farace, Radhia M'kacher, J. H. Bourhis, D. Violot, Alain Bernheim, Claude Parmentier, A Laugé, Vincent Ribrag, Dominique Stoppa-Lyonnet, J Dossou, L F Plassa

Publikováno v: Oncogene. 22:7905-7912

Mantle cell lymphomas (MCL) are characterized by their aggressive behavior and poor response to chemotherapy regimens. We report here evidence of increased in vitro radiation sensitivity in two cell lines that we have generated from two MCL patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144a8369f51bfb71440a0441f35bfad6
https://doi.org/10.1038/sj.onc.1206826

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Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy

Autor: P Bertheau, F Plassa, M Espié, E Turpin, A de Roquancourt, M Marty, F Lerebours, Y Beuzard, A Janin, H de Thé

Publikováno v: The Lancet. 360:852-854

TP53 activation by genotoxic drugs can induce apoptosis or cell-cycle arrest. Thus, whether the gene is mutated or wild type could affect the response of a tumour to chemotherapy. Clinical data are unclear, possibly as a result of heterogeneity of tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b276414fd57389698c87ff6c96d276ea
https://doi.org/10.1016/s0140-6736(02)09969-5

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Changes in allelic imbalances in locally advanced breast cancers after chemotherapy

Autor: M Varna, H Soliman, J-P Feugeas, E Turpin, D Chapelin, L Legrès, L-F Plassa, A de Roquancourt, M Espié, J-L Misset, A Janin, H de Thé, P Bertheau

Publikováno v: British Journal of Cancer

In advanced breast cancers, TP53 mutation is highly predictive of complete response to high-dose epirubicin/cyclophosphamide chemotherapy. In these tumours with an altered control of genomic stability, accumulation of chemotherapy-induced genetic alt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f3fffbd14e675bb5dad7659693ac8e
https://pubmed.ncbi.nlm.nih.gov/17876337

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Identification of cystic fibrosis mutations in the United Arab Emirates. Mutations in brief no. 133. Online

Autor: P M, Frossard, E, Girodon, K P, Dawson, N, Ghanem, F, Plassa, G G, Lestringant, M, Goossens

Publikováno v: Human mutation. 11(5)

We have designed a study aimed at identifying the genetic mutations responsible for cystic fibrosis (CF) in the population of the United Arab Emirates. The prevalence of CF in the UAE is at least 1/15,000 live births and the disease is associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::795fb3f0502681ed5d1fe069ec3c4d26
https://pubmed.ncbi.nlm.nih.gov/10206682

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beta-Thalassemia and hemoglobin types in Argentina: determination of most frequent mutations

Autor: N W, Soria, C L, Tulián, F, Plassa, G A, Roth

Publikováno v: American journal of hematology. 54(2)

In order to know the spectrum of beta-thalassemia alleles and other mutations affecting the beta-globin gene, we analyzed the hemoglobin abnormalities in 24 patients from the Province of Cordoba in Argentina. Molecular screening of samples was perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17a655975f8548b3f9ec07d29192f713
https://pubmed.ncbi.nlm.nih.gov/9034292

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