Zobrazeno 1 - 10
of 779
pro vyhledávání: '"F Peter, Guengerich"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9020 (2024)
Cytochrome P450 (P450) enzymes dominate steroid metabolism. In general, the simple C-hydroxylation reactions are mechanistically straightforward and are generally agreed to involve a perferryl oxygen species (formally FeO3+). Several of the steroid t
Externí odkaz:
https://doaj.org/article/360b5c5b8f9b41ccb18e32215ad5370d
Publikováno v:
Genes and Environment, Vol 43, Iss 1, Pp 1-23 (2021)
Abstract Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives of adenosine, cytosine, and guan
Externí odkaz:
https://doaj.org/article/9456c4b60a2d4344b00971abfd9a7c3e
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100124- (2021)
Externí odkaz:
https://doaj.org/article/f6e0d91b428947cca577d4b74a80d69f
Autor:
Shayantani Chakraborty, Dibyendu Mallick, Mausumi Goswami, F. Peter Guengerich, Anindita Chakrabarty, Goutam Chowdhury
Publikováno v:
Journal of Natural Products. 85:2340-2350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d440d34c6b1fe3d42ecff7facc28c42
https://doi.org/10.1021/acs.jnatprod.2c00521
https://doi.org/10.1021/acs.jnatprod.2c00521
Publikováno v:
Medicinal Chemistry Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6aeef400a6e2ba6b89cf9a1ff9d05a
https://doi.org/10.1007/s00044-023-03078-y
https://doi.org/10.1007/s00044-023-03078-y
Autor:
Jeffrey Y Jian, Kevin D McCarty, Jo Ann W Byl, F Peter Guengerich, Keir C Neuman, Neil Osheroff
Publikováno v:
Nucleic Acids Res
To perform double-stranded DNA passage, type II topoisomerases generate a covalent enzyme-cleaved DNA complex (i.e. cleavage complex). Although this complex is a requisite enzyme intermediate, it is also intrinsically dangerous to genomic stability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a00dba8a24a38260445f90e51df0603
https://europepmc.org/articles/PMC10164583/
https://europepmc.org/articles/PMC10164583/
Autor:
Ambra Pozzi, Scott M. Williams, F. Peter Guengerich, John R. Falck, Jorge H. Capdevila, Megan M. Shuey, James M. Luther, Roy Zent, Shouzuo Wei, Shaojun Mei, Manuel Chiusa, Mahesha H. Gangadhariah, Lindsay N. Sausville
This file contains the primer sequence of CYP2C9* variants (Supplementary Table S1); the SNPs genotyped in the BioVU NSCLC study (Supplementary Table S2); quality control measures of SNPs in the BioVU NSCLC study (Supplementary Table S3); clinical an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308f7412116c1324a40a6f5c93f46538
https://doi.org/10.1158/0008-5472.22426270.v1
https://doi.org/10.1158/0008-5472.22426270.v1
Autor:
Ambra Pozzi, Scott M. Williams, F. Peter Guengerich, John R. Falck, Jorge H. Capdevila, Megan M. Shuey, James M. Luther, Roy Zent, Shouzuo Wei, Shaojun Mei, Manuel Chiusa, Mahesha H. Gangadhariah, Lindsay N. Sausville
Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggressiveness in cancer. Cytochrome P450 variants CYP2C9*2 and CYP2C9*3 encode proteins with reduced en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff77c3335eea0c969f51ecdd1f48097
https://doi.org/10.1158/0008-5472.c.6512281
https://doi.org/10.1158/0008-5472.c.6512281
Publikováno v:
Chemical Research in Toxicology. 35:1805-1808
In the course of studies on the enhancement of 1,2-dibromoethane-induced DNA base pair mutations by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15009ad3e50ba56abd24a3728bb03dd4
https://doi.org/10.1021/acs.chemrestox.2c00068
https://doi.org/10.1021/acs.chemrestox.2c00068
Autor:
Tatiana Y. Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Suneethi Sivakumaran, Eugenia M. Yazlovitskaya, Scott W. Hiebert, F. Peter Guengerich, Michael R. Waterman, Galina I. Lepesheva
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 8, Pp 1552-1563 (2016)
Rapidly multiplying cancer cells synthesize greater amounts of cholesterol to build their membranes. Cholesterol-lowering drugs (statins) are currently in clinical trials for anticancer chemotherapy. However, given at higher doses, statins cause seri
Externí odkaz:
https://doaj.org/article/968e408f60a54a6ab3edc1f98e3a4e63