Zobrazeno 1 - 10
of 11
pro vyhledávání: '"F P Coxon"'
Autor:
Steven P. Luckman, Jukka Mönkkönen, K. M. Chilton, Michael J. Rogers, H L Benford, Roslin Russell, F P Coxon, Seppo Auriola, Julie C. Frith
Publikováno v:
Bone. 24:73S-79S
BPs can be grouped into two general classes according to their chemical structure and the molecular mechanism by which they inhibit osteoclast-mediated bone resorption. The simple BPs can be metabolically incorporated into non-hydrolysable analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc204f0e7b20c8d6fda98fe86729639b
https://doi.org/10.1016/s8756-3282(99)00070-8
https://doi.org/10.1016/s8756-3282(99)00070-8
Autor:
R. Graham G. Russell, Frank Hallock Ebetino, Charles E. McKenna, Xiaolan Chen, Michael J. Rogers, Joy Lynn F. Bala, Boris A. Kashemirov, Anke J. Roelofs, Zhidao Xia, F P Coxon
Publikováno v:
Bioconjugate Chemistry. 19:2308-2310
We report synthesis of the first fluorescently labeled conjugates of risedronate (1), using an epoxide linker strategy enabling conjugation of 1 via its pyridyl nitrogen with the label (carboxyfluorescein). Unlike prior approaches to create fluoresce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ed054ce3d9f20c17aace9f0ddaa812
https://doi.org/10.1021/bc800369c
https://doi.org/10.1021/bc800369c
Publikováno v:
Journal of Bone and Mineral Research. 13:1668-1678
Recent evidence suggests that bisphosphonates (BPs) may inhibit bone resorption by mechanisms that lead to osteoclast apoptosis. We have previously shown that BPs also reduce cell viability and induce apoptosis in the macrophage-like cell line J774.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b9017264b82fe4375f976bcdc5bd1e
https://doi.org/10.1359/jbmr.1998.13.11.1668
https://doi.org/10.1359/jbmr.1998.13.11.1668
Publikováno v:
Journal of Bone and Mineral Research. 13:581-589
Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of metabolic bone diseases. Although the molecular targets of bisphosphonates have not been identified, these compounds inhibit bone resorption by m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d6fb266f6a5c96734fc3a49f190387
https://doi.org/10.1359/jbmr.1998.13.4.581
https://doi.org/10.1359/jbmr.1998.13.4.581
Autor:
Roger J. Phipps, Kathryn L. Kavanagh, Philippa A. Hulley, Roslin Russell, James T. Triffitt, Michael J. Rogers, James E. Dunford, Frank H. Ebetino, Zhidao Xia, Aaron Kwaasi, Udo Oppermann, Mark W. Lundy, Nelson B. Watts, Bobby Lee Barnett, F P Coxon
Publikováno v:
Annals of the New York Academy of Sciences.
The bisphosphonates (BPs) are well established as the treatments of choice for disorders of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, and osteoporosis. There is considerable new knowledge about how BPs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6da7f9e2518fe3b3141f0176eccadd1
http://ora.ox.ac.uk/objects/uuid:5ab21b6c-96f1-42e0-b0c1-ce7fe4190c91
http://ora.ox.ac.uk/objects/uuid:5ab21b6c-96f1-42e0-b0c1-ce7fe4190c91
Publikováno v:
Molecular pharmacology. 54(4)
The exact mechanisms of action of antiresorptive bisphosphonate drugs remain unclear, although they may inhibit bone resorption by mechanisms that can lead to osteoclast apoptosis. These drugs also cause apoptosis in J774 macrophages, probably as a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::339139fd6c364dc1e55b55fa1f2f9852
https://pubmed.ncbi.nlm.nih.gov/9765505
https://pubmed.ncbi.nlm.nih.gov/9765505
Autor:
J. Rojas Navea, Michael J. Rogers, Keith Thompson, Charlotte A. Stewart, Frank H. Ebetino, Joy Lynn F. Bala, Anke J. Roelofs, Boris A. Kashemirov, F P Coxon, Charles E. McKenna
Publikováno v:
Bone. 38:46-47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4126b9acbc390f19e9d6ae27b908b07f
https://doi.org/10.1016/j.bone.2005.12.034
https://doi.org/10.1016/j.bone.2005.12.034
Publikováno v:
Scopus-Elsevier
Bisphosphonates (BPs) are an important class of antiresorptive drugs used in the treatment of bone diseases, including osteoporosis. Although their mechanism of action has not been identified at the molecular level, there is substantial evidence that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8504a8f846fbbea0a01873a92977b25
https://pubmed.ncbi.nlm.nih.gov/8889848
https://pubmed.ncbi.nlm.nih.gov/8889848
Publikováno v:
Biochemical Society Transactions. 24:568S-568S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55c643d0d43f95677a11ae53a3f366e
https://doi.org/10.1042/bst024568sc
https://doi.org/10.1042/bst024568sc