Zobrazeno 1 - 10
of 499
pro vyhledávání: '"F P, Guengerich"'
Publikováno v:
Genes and Environment, Vol 43, Iss 1, Pp 1-23 (2021)
Abstract Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives of adenosine, cytosine, and guan
Externí odkaz:
https://doaj.org/article/9456c4b60a2d4344b00971abfd9a7c3e
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100124- (2021)
Externí odkaz:
https://doaj.org/article/f6e0d91b428947cca577d4b74a80d69f
Autor:
Tatiana Y. Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Suneethi Sivakumaran, Eugenia M. Yazlovitskaya, Scott W. Hiebert, F. Peter Guengerich, Michael R. Waterman, Galina I. Lepesheva
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 8, Pp 1552-1563 (2016)
Rapidly multiplying cancer cells synthesize greater amounts of cholesterol to build their membranes. Cholesterol-lowering drugs (statins) are currently in clinical trials for anticancer chemotherapy. However, given at higher doses, statins cause seri
Externí odkaz:
https://doaj.org/article/968e408f60a54a6ab3edc1f98e3a4e63
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1933-1943 (2014)
Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. In addition, the same enzyme is known to further oxidize 24S-hydroxycholesterol to the 24,25- and 24,
Externí odkaz:
https://doaj.org/article/7d1ea09ad11f4305a01c47c3937ecd61
Autor:
Ingemar Björkhem, Ulf Diczfalusy, Anita Lövgren-Sandblom, Lena Starck, Monica Jonsson, Keri Tallman, Henrik Schirmer, Lilian Bomme Ousager, Peter J. Crick, Yuqin Wang, William J. Griffiths, F. Peter Guengerich
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1165-1172 (2014)
A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product. Some patients with cereb
Externí odkaz:
https://doaj.org/article/576e66e606e24d37898877f880a7b361
Autor:
F. P. Guengerich, Slobodan Rendic
Publikováno v:
Curr Drug Metab
Background:: In clinical practice, chloroquine and hydroxychloroquine are often co-administered with other drugs in the treatment of malaria, chronic inflammatory diseases, and COVID-19. Therefore, their metabolic properties and the effects on the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25585a74101a1a1fc40d9c5fc44d6586
https://doi.org/10.2174/1389200221999201208211537
https://doi.org/10.2174/1389200221999201208211537
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 8, Pp 1610-1617 (2012)
Human cytochrome P450 (P450) 2W1 is still considered an “orphan” because its physiological function is not characterized. To identify its substrate specificity, the purified recombinant enzyme was incubated with colorectal cancer extracts for unt
Externí odkaz:
https://doaj.org/article/2f3f1fcfb78d4ba59f7e77313fee748a
Publikováno v:
J Med Chem
Cytochrome P450 46A1 (CYP46A1) is a central nervous system-specific enzyme, which catalyzes cholesterol 24-hydroxylation. Currently CYP46A1 is being evaluated in a clinical trial for activation by small doses of the anti-HIV drug efavirenz. Eight efa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4638d56eb4c0f479fe518a95ad66f3f8
https://doi.org/10.1021/acs.jmedchem.9b01383
https://doi.org/10.1021/acs.jmedchem.9b01383
Autor:
Steven J. Hughes, Mark A. Morse, Christopher M. Weghorst, Hyesook Kim, Paul B. Watkins, F. Peter Guengerich, Mark B. Orringer, David G. Beer
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 1, Iss 2, Pp 145-153 (1999)
The expression of cytochromes P450 (CYP) in Barrett's esophagus and esophageal squamous mucosa was investigated. Esophagectomy specimens from 23 patients were examined for CYP expression of CYP1A2, CYP3A4, CYP2C9/10, and CYP2E1 by immunohistochemical
Externí odkaz:
https://doaj.org/article/296a291f73cd492bb63c437c02ed9e74
Autor:
Asit Parikh, F. Peter Guengerich
Publikováno v:
BioTechniques, Vol 24, Iss 3, Pp 428-431 (1998)
Random mutagenesis has become a powerful means of studying the effects of a large number of permutations of a particular DNA sequence. As a prime example, libraries of randomized cDNA clones, when translated into their corresponding proteins, can be
Externí odkaz:
https://doaj.org/article/131ba0f955f749f287cbf642157ae06d