Zobrazeno 1 - 10
of 28
pro vyhledávání: '"F P, Bymaster"'
Publikováno v:
Molecular Psychiatry. 12:232-246
Although the neurotransmitter dopamine plays a prominent role in the pathogenesis and treatment of schizophrenia, the dopamine hypothesis of schizophrenia fails to explain all aspects of this disorder. It is increasingly evident that the pathology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a523c3f8e586025900455491a995cfc9
https://doi.org/10.1038/sj.mp.4001924
https://doi.org/10.1038/sj.mp.4001924
Autor:
C C Felder, F P Bymaster
Publikováno v:
Molecular psychiatry. 7
The evidence for the involvement of cholinergic muscarinic receptors in mania and depression is reviewed. Small pilot trials with cholinesterase inhibitors and muscarinic agonists suggest that stimulation of muscarinic receptors may produce an antima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d3adedda0cdf1f0672b80c85e5e2f4
https://pubmed.ncbi.nlm.nih.gov/11986996
https://pubmed.ncbi.nlm.nih.gov/11986996
Autor:
J S, Kennedy, F P, Bymaster, L, Schuh, D O, Calligaro, G, Nomikos, C C, Felder, M, Bernauer, B J, Kinon, R W, Baker, D, Hay, H J, Roth, M, Dossenbach, C, Kaiser, C M, Beasley, J H, Holcombe, M B, Effron, A, Breier
Publikováno v:
International journal of geriatric psychiatry. 16
Olanzapine (OLZ) is unique among currently available antipsychotic medications in its antagonism of a range of receptor systems including dopamine, norepinephrine, serotonin, acetylcholine, and histamine. Olanzapine's mechanistic complexity provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::804501eee12f73d97564694a6a147ff1
https://pubmed.ncbi.nlm.nih.gov/11748788
https://pubmed.ncbi.nlm.nih.gov/11748788
Autor:
J S, Street, W S, Clark, K S, Gannon, J L, Cummings, F P, Bymaster, R N, Tamura, S J, Mitan, D L, Kadam, T M, Sanger, P D, Feldman, G D, Tollefson, A, Breier
Publikováno v:
Archives of general psychiatry. 57(10)
Patients with Alzheimer disease (AD) commonly exhibit psychosis and behavioral disturbances that impair patient functioning, create caregiver distress, and lead to institutionalization. This study was conducted to assess the efficacy and safety of ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01633b510da15e05d6a1a790605e2472
https://pubmed.ncbi.nlm.nih.gov/11015815
https://pubmed.ncbi.nlm.nih.gov/11015815
Publikováno v:
Cellular signalling. 11(6)
Muscarinic agonists stimulated arachidonic acid release from 10- to 32-fold in Chinese hamster ovary (CHO) cells transfected with muscarinic M1, M3 and M5 receptor subtypes. Muscarinic agonists liberated arachidonic acid from the cAMP-coupled M2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::027595d6bf7b6d7f339d838a7d7e39d9
https://pubmed.ncbi.nlm.nih.gov/10400314
https://pubmed.ncbi.nlm.nih.gov/10400314
Autor:
F. P. Bymaster, Wei Zhang
Publikováno v:
Psychopharmacology. 141(3)
The atypical antipsychotic olanzapine was compared to other atypical as well as typical antipsychotic agents for in vivo occupancy of D1, D2, D3, 5HT2, and muscarinic receptors in rat brain. Blockade of D2 receptors was determined by measuring the le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4379b1d84e1b51022f54ef5f208860
https://pubmed.ncbi.nlm.nih.gov/10027508
https://pubmed.ncbi.nlm.nih.gov/10027508
Autor:
M J, Sheardown, H E, Shannon, M D, Swedberg, P D, Suzdak, F P, Bymaster, P H, Olesen, C H, Mitch, J S, Ward, P, Sauerberg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
The analgesic effects of a series of muscarinic agonists were investigated by use of the mouse acetic acid writhing, grid-shock, hot-plate and tail-flick tests. The compounds tested were oxotremorine, pilocarpine, arecoline, aceclidine, RS86 and four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79ecf1e43cfe545617ce8048e2834e84
https://pubmed.ncbi.nlm.nih.gov/9152396
https://pubmed.ncbi.nlm.nih.gov/9152396
Autor:
M D, Swedberg, M J, Sheardown, P, Sauerberg, P H, Olesen, P D, Suzdak, K T, Hansen, F P, Bymaster, J S, Ward, C H, Mitch, D O, Calligaro, N W, Delapp, H E, Shannon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
Butylthio[2.2.2] ((+)-(S)-3-(4-(Butylthio)-1,2,5-thiadiazol-3-yl)-1-azabicyclo[2.2. 2] octane) is an agonist/antagonist at muscarinic receptors. The analgesic potential of butylthio[2.2.2] was assessed in the mouse by use of the grid-shock, tail-flic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f53abf6a2ac73b4b6897589c371673a
https://pubmed.ncbi.nlm.nih.gov/9152397
https://pubmed.ncbi.nlm.nih.gov/9152397
Autor:
H E, Shannon, M J, Sheardown, F P, Bymaster, D O, Calligaro, N W, Delapp, J, Gidda, C H, Mitch, B D, Sawyer, P W, Stengel, J S, Ward, D T, Wong, P H, Olesen, P D, Suzdak, P, Sauerberg, M D, Swedberg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
Butylthio[2.2.2], ((+)-(S)-3-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo[2.2.2] octane; LY297802/NNC11-1053) is a muscarinic receptor ligand which is equiefficacious to morphine in producing antinociception. In vitro, butylthio[2.2.2] had high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60ea834b475d911247439bbb12b0e68f
https://pubmed.ncbi.nlm.nih.gov/9152398
https://pubmed.ncbi.nlm.nih.gov/9152398
Publikováno v:
The Journal of clinical psychiatry. 58
Classical (typical) antipsychotic drugs are in wide use clinically, but some patients do not respond at all to treatment, while in others, negative symptoms and cognitive deficits fail to respond. Also, these drugs often cause serious motor disturban
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d47ce3ac9baac8f7af2dccbc6c8be439
https://pubmed.ncbi.nlm.nih.gov/9265914
https://pubmed.ncbi.nlm.nih.gov/9265914