Výsledky vyhledávání

Interleukin 4 inhibits the proliferation and promotes the maturation of human leukemic early B cells

Autor: Christian Schmitt, Franz Mentz, F Ouaaz, Jean-Jaques Guillosson, Patrice Debré, Ariane Michel, M. Djavad Mossalayi, Hélène Merle-Béral, Michel Arock

Publikováno v: European Journal of Haematology. 51:276-281

The effects of interleukin 4 (IL-4) on human leukemic precursor B-cell lines were investigated. Recombinant IL-4 (rIL-4) was added to three acute lymphoblastic leukemia-derived pre B-cell lines: Reh, Km3 and Nalm-6. Our results show that rIL-4 signif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3492582563625548806a2dd980ac5c
https://doi.org/10.1111/j.1600-0609.1993.tb01608.x

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The 25-kDa soluble CD23 activates type III constitutive nitric oxide-synthase activity via CD11b and CD11c expressed by human monocytes

Autor: J P Aubry, N Dugas, S Lecoanet-Henchoz, F Ouaaz, H Zhao, J F Delfraissy, P Graber, J P Kolb, B Dugas, J Y Bonnefoy

Publikováno v: The Journal of Immunology. 159:614-622

CD23, a low-affinity receptor for IgE, was recently shown to bind to CD11b and CD11c molecules on human monocytes. The 25-kDa soluble fragment of CD23 (sCD23), was tested for its capacity to elicit various signaling pathways in human monocytes. sCD23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a7b79f3c5913c3789203f39851b4fe2
https://doi.org/10.4049/jimmunol.159.2.614

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Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells

Autor: F Ouaaz, Mossalayi, Michel Arock, B Dugas, Nathalie Dugas, A Calenda, Patrice Debré, P.-A. Becherel, A Leotard, F Mentz, J Dornand

Publikováno v: Blood. 88:3528-3534

All trans retinoic acid and vitamin D3 derivatives are well known for their antileukemic activity, while the precise mechanism of this effect remains to be clarified. Using human leukemic U937 and THP-1 promonocytic cell lines, we analyzed the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e05c9559f9dbe26845f1dff209e1b3c
https://doi.org/10.1182/blood.v88.9.3528.bloodjournal8893528

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Theophylline synergizes with chlorambucil in inducing apoptosis of B- chronic lymphocytic leukemia cells

Autor: Sylvie Baudet, Sandra Ktorza, F Mentz, Mossalayi, F Issaly, F Ouaaz, J. L. Binet, M Semichon, Hélène Merle-Béral

Publikováno v: Blood. 88:2172-2182

We tested the effects of theophylline, a phosphodiesterase inhibitor inducing intracellular accumulation of cyclic adenosine monophosphate (cAMP), on malignant B cells from 15 patients with B-chronic lymphocytic leukemia (B-CLL). We observed a large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96846a78ed1a58ad76c5eaf0bf2d8518
https://doi.org/10.1182/blood.v88.6.2172.bloodjournal8862172

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Role of IgE Immune Complexes in the Regulation of HIV-1 Replication and Increased Cell Death of Infected U1 Monocytes: Involvement of CD23/FcεRII-Mediated Nitric Oxide and Cyclic AMP Pathways

Autor: Mikovits J, F Ouaaz, B Dugas, Mossalayi, FW Ruscetti, Patrice Debré, Agut H

Publikováno v: Molecular Medicine. 2:38-49

IgE/anti-IgE immune complexes (IgE-IC) induce the release of multiple mediators from monocytes/macrophages and the monocytic cell line U937 following the ligation of the low-affinity Fce receptors (FceRII/CD23). These effects are mediated through an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a15154fb9af7cd1f6c9ca63cfdc1fcc9
https://doi.org/10.1007/bf03402201

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The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen

Autor: I Vouldoukis, P.-A. Becherel, V Riveros-Moreno, Salvador Moncada, B Dugas, Patrice Debré, M.D. Mossalayi, F. Ouaaz

Publikováno v: Proceedings of the National Academy of Sciences. 92:7804-7808

Serum IgE concentrations and the expression of the low-affinity receptor for IgE (Fc epsilon RII/CD23) are increased in cutaneous leishmaniasis or after immune challenge with Leishmania antigens. In vitro, the ligation of CD23 by IgE-anti-IgE immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf7b29ab76f49f13ef049a4a93e2f16
https://doi.org/10.1073/pnas.92.17.7804

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Early human thymocyte proliferation is regulated by an externally controlled autocrine transforming growth factor-beta 1 mechanism

Autor: Patrice Debré, A H Dalloul, F Ouaaz, Mossalayi, FW Ruscetti, Catherine Blanc, F Mentz

Publikováno v: Blood. 85:3594-3601

Early thymocytes undergo extensive proliferation after their entry into the thymus, but cellular interactions and cytokines regulating this intrathymic step remain to be determined. We analyzed the effects of various T-cell growth factors and cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::057cf223f804765cb53c824388a423ed
https://doi.org/10.1182/blood.v85.12.3594.bloodjournal85123594

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Involvement of cAMP in CD3 T cell receptor complex- and CD2-mediated apoptosis of human thymocytes

Autor: Patrice Debré, Frank Mentz, F Ouaaz, M. Djavad Mossalayi

Publikováno v: European Journal of Immunology. 25:1798-1801

During intrathymic T cell development, elimination of autoreactive T cell clones by programmed cell death (PCD or apoptosis) is an essential mechanism for self tolerance. The precise intracellular second messengers that lead to this process remain to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88d439dc923362da61dc92eb98285e1
https://doi.org/10.1002/eji.1830250648

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Ligation of CD23 activates soluble guanylate cyclase in human monocytes via an L-arginine–dependent mechanism

Autor: Marika Sarfati, F Ouaaz, Jean-Pierre Kolb, Michel Arock, Djavad Mossalayi, B Dugas, Patrice Debré, Nathalie Paul-Eugène

Publikováno v: Journal of Leukocyte Biology. 57:160-167

Transduction through FcR2/CD23 was analyzed in normal human monocytes using immunoglobulin E (IgE)-anti-IgE immune complexes (IgE ICs) and monoclonal antibodies (mAbs) to CD23. Anti-CD23 mAb and IgE IC triggered a time-dependent increase in cGMP and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fe5dde408757cd171dc8abd9148283
https://doi.org/10.1002/jlb.57.1.160

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Maturation of acute T-lymphoblastic leukemia cells after CD2 ligation and subsequent treatment with interleukin-2

Autor: Ariane Michel, Georges Bismuth, P Herve, F Ouaaz, Mossalayi, F Mentz, Patrice Debré, Hélène Merle-Béral, Catherine Blanc

Publikováno v: Blood. 84:1182-1192

In this study, we have investigated the ability of various cytokines to induce the maturation of acute lymphoblastic leukemia (T-ALL) cells with early T-cell phenotype. Leukemic blasts from 17 untreated T-ALL patients were assayed for their ability t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245278fe29f2591198016c02a5a7858b
https://doi.org/10.1182/blood.v84.4.1182.bloodjournal8441182

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