Zobrazeno 1 - 10
of 1 161
pro vyhledávání: '"F O'Connell"'
Autor:
Kanikkai Raja Aseer, Caio Henrique Mazucanti, Jennifer F. O’Connell, Isabel González-Mariscal, Anjali Verma, Qin Yao, Christopher Dunn, Qing-Rong Liu, Josephine M. Egan, Máire E. Doyle
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101917- (2024)
Externí odkaz:
https://doaj.org/article/fc2998fbbee947e0b1e63770929e59bb
Autor:
Kanikkai Raja Aseer, Caio Henrique Mazucanti, Jennifer F. O’Connell, Isabel González-Mariscal, Anjali Verma, Qin Yao, Christopher Dunn, Qing-Rong Liu, Josephine M. Egan, Máire E. Doyle
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101906- (2024)
Objective: Type 1 diabetes (T1D) occurs because of islet infiltration by autoreactive immune cells leading to destruction of beta cells and it is becoming evident that beta cell dysfunction partakes in this process. We previously reported that geneti
Externí odkaz:
https://doaj.org/article/f9b137e5ebbd4b2fba8b127ac6e303d3
Publikováno v:
Biology, Vol 13, Iss 1, p 36 (2024)
Cellular senescence is defined as an irreversible cell cycle arrest accompanied by morphological and physiological alterations during aging. Red ginseng (RG), processed from fresh ginseng (Panax ginseng C.A. Meyer) with a one-time steaming and drying
Externí odkaz:
https://doaj.org/article/d6fb219b40ee41978519e844b6b1404a
Autor:
Da-Yeon Lee, Su-Jeong Lee, Prabha Chandrasekaran, Gopal Lamichhane, Jennifer F. O’Connell, Josephine M. Egan, Yoo Kim
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1165 (2023)
Dietary interventions with bioactive compounds have been found to suppress the accumulation of senescent cells and senescence-associated secretory phenotypes (SASPs). One such compound, curcumin (CUR), has beneficial health and biological effects, in
Externí odkaz:
https://doaj.org/article/d8be756d22cc4745a4108e74df252f51
Autor:
Yoo Kim, Sudeep Gautam, Kanikkai Raja Aseer, Jaekwan Kim, Prabha Chandrasekaran, Caio Henrique Mazucanti, Paritosh Ghosh, Jennifer F. O’Connell, Máire E. Doyle, Ashley Appleton, Elin Lehrmann, Qing-Rong Liu, Josephine M. Egan
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-13 (2020)
Abstract Cannabinoid 1 receptor (CB1R) expression is upregulated in the liver with viral hepatitis, cirrhosis, and both alcoholic and non-alcoholic fatty liver disease (FLD), whereas its expression is muted under usual physiological conditions. Inhib
Externí odkaz:
https://doaj.org/article/9666fd9589f04fc68c08c674919873b5
Autor:
Jyoti Iyer, Lindsey K Gentry, Mary Bergwell, Amy Smith, Sarah Guagliardo, Peter A Kropp, Prabhu Sankaralingam, Yan Liu, Eric Spooner, Bruce Bowerman, Kevin F O'Connell
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1009799 (2022)
Centrioles are submicron-scale, barrel-shaped organelles typically found in pairs, and play important roles in ciliogenesis and bipolar spindle assembly. In general, successful execution of centriole-dependent processes is highly reliant on the abili
Externí odkaz:
https://doaj.org/article/5bcfdfa314f642979898e75a381717f3
Autor:
John F. O'Connell, George Williams
Airlines are buffeted by fluctuating political and economic landscapes, ever-changing competition, technology developments, globalization, increasing deregulation and evolving customer requirements. As a consequence all sectors of the air transport i
Autor:
Qing-Rong Liu, Kanikkai Raja Aseer, Qin Yao, Xiaoming Zhong, Paritosh Ghosh, Jennifer F. O’Connell, Josephine M. Egan
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Type 1 diabetes mellitus (T1DM) is an autoimmune disease resulting from loss of insulin-secreting β-cells in islets of Langerhans. The loss of β-cells is initiated when self-tolerance to β-cell-derived contents breaks down, which leads to T cell-m
Externí odkaz:
https://doaj.org/article/72eb20ce937f45c88093881f016d9ad4
Autor:
S. Ghosh, J. F. O'Connell, O. D. Carlson, I. González‐Mariscal, Y. Kim, R. Moaddel, P. Ghosh, J. M. Egan
Publikováno v:
Obesity Science & Practice, Vol 5, Iss 4, Pp 383-394 (2019)
Summary Aim Linoleic acid (LA) is an essential fatty acid involved in the biosynthesis of arachidonic acid and prostaglandins. LA is known to induce obesity and insulin resistance. In this study, two concentrations of LA with or without added glucose
Externí odkaz:
https://doaj.org/article/0dbe93428bcf47c8a0edcd6963a7d357
Publikováno v:
Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Although type 2 diabetes mellitus (T2DM) is primarily characterized by sustained high levels of circulating glucose, other factors, such as obesity, chronic inflammation, fatty liver, and islet dysfunction significantly contribute
Externí odkaz:
https://doaj.org/article/435cd482ff914ee38c0f7a1f1c6ad827