Zobrazeno 1 - 10
of 110
pro vyhledávání: '"F Nina, Papavasiliou"'
Autor:
Sara Đaković, Johan P Zeelen, Anastasia Gkeka, Monica Chandra, Monique van Straaten, Konstantina Foti, Janet Zhong, Evi P Vlachou, Francisco Aresta-Branco, Joseph P Verdi, F Nina Papavasiliou, C Erec Stebbins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011621 (2023)
Long-term immune evasion by the African trypanosome is achieved through repetitive cycles of surface protein replacement with antigenically distinct versions of the dense Variant Surface Glycoprotein (VSG) coat. Thousands of VSG genes and pseudo-gene
Externí odkaz:
https://doaj.org/article/2a7c6745a9b94c0cacb4fc4bd7e1493b
Autor:
Riccardo Pecori, Weicheng Ren, Mohammad Pirmoradian, Xianhuo Wang, Dongbing Liu, Mattias Berglund, Wei Li, Rafail Nikolaos Tasakis, Salvatore Di Giorgio, Xiaofei Ye, Xiaobo Li, Annette Arnold, Sandra Wüst, Martin Schneider, Karthika-Devi Selvasaravanan, Yvonne Fuell, Thorsten Stafforst, Rose-Marie Amini, Kristina Sonnevi, Gunilla Enblad, Birgitta Sander, Björn Engelbrekt Wahlin, Kui Wu, Huilai Zhang, Dominic Helm, Marco Binder, F. Nina Papavasiliou, Qiang Pan-Hammarström
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106864- (2023)
Summary: Diffuse large B cell lymphoma (DLBCL) is one of the most common types of aggressive lymphoid malignancies. Here, we explore the contribution of RNA editing to DLBCL pathogenesis. We observed that DNA mutations and RNA editing events are ofte
Externí odkaz:
https://doaj.org/article/06e7c6d062c04ab1819616c3c1a37e1a
Autor:
Anastasia Gkeka, Francisco Aresta-Branco, Gianna Triller, Evi P. Vlachou, Monique van Straaten, Mirjana Lilic, Paul Dominic B. Olinares, Kathryn Perez, Brian T. Chait, Renata Blatnik, Thomas Ruppert, Joseph P. Verdi, C. Erec Stebbins, F. Nina Papavasiliou
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112262- (2023)
Summary: The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we describe the antibody repertoires elicited by different VSGs. W
Externí odkaz:
https://doaj.org/article/eb43510b214a4df1a0e7c607d76c984e
Autor:
Monica Chandra, Sara Đaković, Konstantina Foti, Johan P Zeelen, Monique van Straaten, Francisco Aresta-Branco, Eliane Tihon, Nicole Lübbehusen, Thomas Ruppert, Lucy Glover, F Nina Papavasiliou, C Erec Stebbins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 2, p e0011093 (2023)
During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of several thousand genes and pseudogenes, and switching to antigen
Externí odkaz:
https://doaj.org/article/751ce205165247368209f63d3c1aca63
Autor:
Gianna Triller, Evi P. Vlachou, Hamidreza Hashemi, Monique van Straaten, Johan P. Zeelen, Yosip Kelemen, Carly Baehr, Cheryl L. Marker, Sandra Ruf, Anna Svirina, Monica Chandra, Katharina Urban, Anastasia Gkeka, Sebastian Kruse, Andreas Baumann, Aubry K. Miller, Marc Bartel, Marco Pravetoni, C. Erec Stebbins, F. Nina Papavasiliou, Joseph P. Verdi
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112049- (2023)
Summary: Poorly immunogenic small molecules pose challenges for the production of clinically efficacious vaccines and antibodies. To address this, we generate an immunization platform derived from the immunogenic surface coat of the African trypanoso
Externí odkaz:
https://doaj.org/article/c7ecefeb83cd43648db62b9d9e7b1931
Autor:
Alexander Hempelmann, Laura Hartleb, Monique van Straaten, Hamidreza Hashemi, Johan P. Zeelen, Kevin Bongers, F. Nina Papavasiliou, Markus Engstler, C. Erec Stebbins, Nicola G. Jones
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109923- (2021)
Summary: The dense variant surface glycoprotein (VSG) coat of African trypanosomes represents the primary host-pathogen interface. Antigenic variation prevents clearing of the pathogen by employing a large repertoire of antigenically distinct VSG gen
Externí odkaz:
https://doaj.org/article/c3acb4d7657a4e0b8cad190d14971cdf
Autor:
Rafail Nikolaos Tasakis, Georgios Samaras, Anna Jamison, Michelle Lee, Alexandra Paulus, Gabrielle Whitehouse, Laurent Verkoczy, F Nina Papavasiliou, Marilyn Diaz
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255169 (2021)
Since the first case of COVID-19 in December 2019 in Wuhan, China, SARS-CoV-2 has spread worldwide and within a year and a half has caused 3.56 million deaths globally. With dramatically increasing infection numbers, and the arrival of new variants w
Externí odkaz:
https://doaj.org/article/20d9691c69244f98842dd8b3ab74a933
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system fo
Externí odkaz:
https://doaj.org/article/aa06b14acc704be0b85627d28f67eda1
Autor:
Xiangdong Lu, Chi-Shuen Chu, Terry Fang, Violeta Rayon-Estrada, Fang Fang, Alina Patke, Ye Qian, Stephen H. Clarke, Ari M. Melnick, Yi Zhang, F. Nina Papavasiliou, Robert G. Roeder
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 472-485.e5 (2019)
Summary: The NuRD complex contains both chromatin remodeling and histone deacetylase activities. Mice lacking the MTA2 subunit of NuRD show developmental defects in pro-B, pre-B, immature B, and marginal zone B cells, and abnormal germinal center B c
Externí odkaz:
https://doaj.org/article/717fe5138aec4299ab71faf0f9b1d0a2
Autor:
Dewi Harjanto, Theodore Papamarkou, Chris J. Oates, Violeta Rayon-Estrada, F. Nina Papavasiliou, Anastasia Papavasiliou
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
RNA editing rate detected from bulk RNA-seq data can vary widely. Here, by constructing a hierarchical Bayesian model, the authors report substantial variance in editing signatures detected by RNA-seq data from both single cells and a cognate bulk sa
Externí odkaz:
https://doaj.org/article/39669e9caefe42a893d07c69afbb336f