Zobrazeno 1 - 10
of 2 677
pro vyhledávání: '"F Nelson"'
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Cochlear implants (CI) have revolutionized the treatment of patients with severe to profound sensory hearing loss by providing a method of bypassing normal hearing to directly stimulate the auditory nerve. A further advance in the field has been the
Externí odkaz:
https://doaj.org/article/25ef7089e8c749a7894d23de2f02b8b2
Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea
Autor:
Ksenia A. Aaron, Katja Pekrun, Patrick J. Atkinson, Sara E. Billings, Julia M. Abitbol, Ina A. Lee, Yasmin Eltawil, Yuan-Siao Chen, Wuxing Dong, Rick F. Nelson, Mark A. Kay, Alan G. Cheng
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 413-428 (2023)
Adeno-associated virus (AAV)-mediated gene transfer has shown promise in rescuing mouse models of genetic hearing loss, but how viral capsid and promoter selection affects efficacy is poorly characterized. Here, we tested combinations of AAVs and pro
Externí odkaz:
https://doaj.org/article/12dd1baf9a7e41769ec3b2c66b940104
Autor:
Gloria K. E. Zodanu, John H. Hwang, Zubin Mehta, Carlos Sisniega, Alexander Barsegian, Xuedong Kang, Reshma Biniwale, Ming-Sing Si, Gary M. Satou, Nancy Halnon, UCLA Congenital Heart Defect BioCore Faculty, Wayne W. Grody, Glen S. Van Arsdell, Stanley F. Nelson, Marlin Touma
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5469 (2024)
Fibrillin-1 and fibrillin-2, encoded by FBN1 and FBN2, respectively, play significant roles in elastic fiber assembly, with pathogenic variants causing a diverse group of connective tissue disorders such as Marfan syndrome (MFS) and congenital contra
Externí odkaz:
https://doaj.org/article/9d710e9660e847b7a5914b462c7b9909
Publikováno v:
Cleaner Engineering and Technology, Vol 16, Iss , Pp 100671- (2023)
Hydrocarbon industry flaring practices emit large amounts of unburned hydrocarbons and climate forcers, creating environmental and social impacts. The objective of this study is to thoroughly compare different flaring technologies in situations where
Externí odkaz:
https://doaj.org/article/f75f71e3cf0e4d9581f9464ac291aa7c
Autor:
Hyejin Kim, Euiseok Hwang, Dongseong Kim, Jin-Hee Cho, Terrence J. Moore, Frederica F. Nelson, Hyuk Lim
Publikováno v:
IEEE Access, Vol 11, Pp 40511-40524 (2023)
The moving target defense (MTD) is a proactive cybersecurity defense technique that constantly changes potentially vulnerable points to be attacked, to confuse the attackers, making it difficult for attackers to infer the system configuration and nul
Externí odkaz:
https://doaj.org/article/155d995105f84a90b5dc21fc48c290b2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Duchenne Muscular Dystrophy (DMD)’s complex multi-system pathophysiology, coupled with the cost-prohibitive logistics of multi-year drug screening and follow-up, has hampered the pursuit of new therapeutic approaches. Here we conducted a systematic
Externí odkaz:
https://doaj.org/article/f5e601e97c20499db387a24adf0cb3d4
Autor:
Shirley Nieves-Rodriguez, Florian Barthélémy, Jeremy D. Woods, Emilie D. Douine, Richard T. Wang, Deirdre D. Scripture-Adams, Kevin N. Chesmore, Francesca Galasso, M. Carrie Miceli, Stanley F. Nelson
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Muscle damage and fibro-fatty replacement of skeletal muscles is a main pathologic feature of Duchenne muscular dystrophy (DMD) with more proximal muscles affected earlier and more distal affected later in the disease course, suggesting that differen
Externí odkaz:
https://doaj.org/article/9a27a0c852384f55bc7769d063aa2045
Autor:
Lauren G. Mascibroda, Mohammad Shboul, Nathan D. Elrod, Laurence Colleaux, Hanan Hamamy, Kai-Lieh Huang, Natoya Peart, Moirangthem Kiran Singh, Hane Lee, Barry Merriman, Jeanne N. Jodoin, Poojitha Sitaram, Laura A. Lee, Raja Fathalla, Baeth Al-Rawashdeh, Osama Ababneh, Mohammad El-Khateeb, Nathalie Escande-Beillard, Stanley F. Nelson, Yixuan Wu, Liang Tong, Linda J. Kenney, Sudipto Roy, William K. Russell, Jeanne Amiel, Bruno Reversade, Eric J. Wagner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The integrator complex is required for the synthesis of protein coding and non-coding RNA and contains the protein INTS13. Here, the authors find germline mutations in INTS13 in two families with oral facial digital syndrome and show that the mutatio
Externí odkaz:
https://doaj.org/article/35883c108c1d4e72ba468a3fd1444767
Autor:
Deirdre D. Scripture-Adams, Kevin N. Chesmore, Florian Barthélémy, Richard T. Wang, Shirley Nieves-Rodriguez, Derek W. Wang, Ekaterina I. Mokhonova, Emilie D. Douine, Jijun Wan, Isaiah Little, Laura N. Rabichow, Stanley F. Nelson, M. Carrie Miceli
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A method to isolate and sequence individual nuclei from human and mouse muscle biopsies provides further insight into the mechanisms of dystrophin loss and repair, in the context of Duchenne muscular dystrophy.
Externí odkaz:
https://doaj.org/article/52c54e56cb454536bdffeb1964579512
Autor:
Taylor F. Nelson, Rebekka Baumgartner, Madalina Jaggi, Stefano M. Bernasconi, Glauco Battagliarin, Carsten Sinkel, Andreas Künkel, Hans-Peter E. Kohler, Kristopher McNeill, Michael Sander
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
This study applies stable carbon isotope labelling to study polymer biodegradation in soils. This labelling enables accurate and precise tracking of polymer carbon during biodegradation and, thereby, provides a holistic picture of this process.
Externí odkaz:
https://doaj.org/article/2d37a9b771ee493da8560d2bc4c24ba7