Výsledky vyhledávání

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

The First Preclinical Pharmacotoxicological Safety Assessment of CGS 35601, a Triple Vasopeptidase Inhibitor, in Chronically Instrumented, Conscious, and Unrestrained Spontaneously Hypertensive Rats

Autor: K. Belleville, R. Lepage, M. Beaudoin, Bruno Battistini, J. Cayer, F. Nantel, O. Benrezzak, A. Blouin, Pierre Sirois, Arco Y. Jeng, Philippe Daull

Publikováno v: Drug and Chemical Toxicology. 29:183-202

CGS 35601 is a triple vasopeptidase inhibitor (VPI) of angiotensin-converting enzyme, neutral endopeptidase, and endothelin-converting enzyme-1 with respective IC50 values of 22, 2, and 55 nM. We characterized the safety profile and toxicity of escal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c60a219978b321fe330cb7b815945
https://doi.org/10.1080/01480540600566717

Zobrazit plný text záznamu

Plný text ve formátu HTML

Triple Vasopeptidase Inhibition of Angiotensinconverting Enzyme/Neutral Endopeptidase/Endothelinconverting Enzyme Activities on the Hemodynamic Profile of Chronically Instrumented Unrestrained Conscious Spontaneously Hypertensive Rats

Autor: F. Nantel, Pierre Sirois, Philippe Daull, Bruno Battistini, André Blouin, Arco Y. Jeng

Publikováno v: Journal of Cardiovascular Pharmacology. 44:S398-S401

Inhibition of the renin-angiotensin system with an angiotensin-converting enzyme inhibitor (ACEi) is an effective therapy in hypertension. Vasopeptidase inhibition was initially proposed with compounds inhibiting both angiotensin-converting enzyme an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b92cbc25b40ded2c643f169bc9928b0
https://doi.org/10.1097/01.fjc.0000166293.79948.09

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

FRI0429 What Is The Location of Dactylitis in Ankylosing Spondylitis and Psoriatic Arthritis Patients and How Do They Respond To Anti-TNF Treatment?: Table 1

Autor: R. Arendse, P. Rahman, J.A. Avina-Zubieta, D. Choquette, M. Zummer, M. Baker, J. Stewart, I. Fortin, M. Teo, E. Rampakakis, E. Psaradellis, B. Osborne, C. Tkaczyk, K. Maslova, F. Nantel, A.J. Lehman

Publikováno v: Annals of the Rheumatic Diseases. 75:591.1-591

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edb99b49d98a76bf8611e0448aa8f78a
https://doi.org/10.1136/annrheumdis-2016-eular.4255

Zobrazit plný text záznamu

AB0220 What Proportion of Patients Fail To Achieve CDAI and SDAI Remission Based on Physician Global Assessment? An Analysis from A Prospective, Observational Registry

Autor: M. Starr, B. Haraoui, D. Choquette, L. Bessette, A. Chow, P. Baer, S. Kapur, J.T. Kelsall, M. Teo, E. Rampakakis, E. Psaradellis, F. Nantel, A.J. Lehman, B. Osborne, K. Maslova, C.M. Tkaczyk

Publikováno v: Annals of the Rheumatic Diseases. 75:973.2-973

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ba4126d84f0b1856ffb81b19265fb66
https://doi.org/10.1136/annrheumdis-2016-eular.4801

Zobrazit plný text záznamu

Functional effects of long-term activation on human β2- and β3-adrenoceptor signalling

Autor: Michel Bouvier, F Nantel, Stefano Marullo, Arthur Donny Strosberg

Publikováno v: Scopus-Elsevier

The functional effects of long-term activation of beta-adrenoceptors were investigated by measuring adenylyl cyclase activity, cyclic AMP accumulation and cyclic AMP-dependent protein kinase activity in CHW and L cells expressing either human beta 2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e097d5d3beab073221bb7f23d138795
https://doi.org/10.1111/j.1476-5381.1995.tb13311.x

Zobrazit plný text záznamu

Variability in the regulation of β-adrenoceptor subtypes

Autor: Stefano Marullo, F Nantel, Michel Bouvier, Arthur Donny Strosberg

Publikováno v: Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4f8450b196fcf3f8aff4261a1703a1
https://doi.org/10.1042/bst0230126

Zobrazit plný text záznamu

Bradykinin B(1) receptor antagonist R954 inhibits eosinophil activation/proliferation/migration and increases TGF-beta and VEGF in a murine model of asthma

Autor: F. Nantel, Luciana M.C. Vasquez-Pinto, Sonia Jancar, Pierre Sirois

Publikováno v: Neuropeptides. 44(2)

In the present study the effects of bradykinin receptor antagonists were investigated in a murine model of asthma using BALB/c mice immunized with ovalbumin/alum and challenged twice with aerosolized ovalbumin. Twenty four hours later eosinophil prol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ed29fb71c6f40149a3481ea8120961
https://pubmed.ncbi.nlm.nih.gov/19962193

Zobrazit plný text záznamu

Pharmacological Evaluation of the Angiotensin, Kinin, and Neurokinin Receptors on the Rabbit Vena Cava

Autor: Domenico Regoli, Nour Eddine Rhaleb, N. Rouissi, F. Nantel, D. Jukic

Publikováno v: Journal of Cardiovascular Pharmacology. 18:398-405

Angiotensin II, bradykinin, and substance P are powerful vasoconstrictors of venous smooth muscle. In this report, we have characterized the receptors and the cellular mechanisms of these vasoactive peptides on a new isolated smooth muscle preparatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf17656947af78ae94b1a82bb462e72
https://doi.org/10.1097/00005344-199109000-00013

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání