Zobrazeno 1 - 10
of 45
pro vyhledávání: '"F Michael, Yakes"'
Autor:
A. Douglas Laird, Peter Lamb, David J. Matthews, Olivia Yturralde, Stephanie Dale, Sanh T. Lam, Frauke Bentzien, Kelly Engell, Felix Chu, F. Michael Yakes, Artur Plonowski, Jenny Young, Jason Chen, Wendy Abulafia, Paul Keast, Charles K. Marlowe, Wentao Zhang, Christopher T. Jaeger, Peiwen Yu, Kwang-Ai Won, Jianming Wu, Xiangnan Du, Fawn Qian, Pin P. Hsu, Kyoko Yamaguchi, Paul Foster
Dose-response relationships for inhibition of PI3K pathway signaling by XL147 in tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260634cb87fb5d622eb4168f46e64fc0
https://doi.org/10.1158/1535-7163.22501281.v1
https://doi.org/10.1158/1535-7163.22501281.v1
Autor:
A. Douglas Laird, Peter Lamb, David J. Matthews, Olivia Yturralde, Stephanie Dale, Sanh T. Lam, Frauke Bentzien, Kelly Engell, Felix Chu, F. Michael Yakes, Artur Plonowski, Jenny Young, Jason Chen, Wendy Abulafia, Paul Keast, Charles K. Marlowe, Wentao Zhang, Christopher T. Jaeger, Peiwen Yu, Kwang-Ai Won, Jianming Wu, Xiangnan Du, Fawn Qian, Pin P. Hsu, Kyoko Yamaguchi, Paul Foster
Effects of XL147 on PI3K Signaling Pathway in OVCAR-3 and U87-MG cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f71be1beb32a7e6d834de7d7f0c096d
https://doi.org/10.1158/1535-7163.22501287.v1
https://doi.org/10.1158/1535-7163.22501287.v1
Autor:
Alison H. Joly, Yu-Chien Chou, Justin Lesch, Lillian Lee, Stefan Engst, A. Douglas Laird, Andrew You, Jessica Orf, Belinda Cancilla, Frauke Bentzien, Felix Chu, Fawn Qian, Peiwen Yu, Yongchang Shi, Kyoko Yamaguchi, Jenny Tan, Jason Chen, F. Michael Yakes
PDF file - 104KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cd3621fbfa51d438f48142646da225
https://doi.org/10.1158/1535-7163.22496638.v1
https://doi.org/10.1158/1535-7163.22496638.v1
Autor:
A. Douglas Laird, Peter Lamb, David J. Matthews, Olivia Yturralde, Stephanie Dale, Sanh T. Lam, Frauke Bentzien, Kelly Engell, Felix Chu, F. Michael Yakes, Artur Plonowski, Jenny Young, Jason Chen, Wendy Abulafia, Paul Keast, Charles K. Marlowe, Wentao Zhang, Christopher T. Jaeger, Peiwen Yu, Kwang-Ai Won, Jianming Wu, Xiangnan Du, Fawn Qian, Pin P. Hsu, Kyoko Yamaguchi, Paul Foster
Dysregulation of PI3K/PTEN pathway components, resulting in hyperactivated PI3K signaling, is frequently observed in various cancers and correlates with tumor growth and survival. Resistance to a variety of anticancer therapies, including receptor ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3a94f3645fe9f5dc53f0c5c6b6714f
https://doi.org/10.1158/1535-7163.c.6536730.v1
https://doi.org/10.1158/1535-7163.c.6536730.v1
Autor:
A. Douglas Laird, Peter Lamb, David J. Matthews, Olivia Yturralde, Stephanie Dale, Sanh T. Lam, Frauke Bentzien, Kelly Engell, Felix Chu, F. Michael Yakes, Artur Plonowski, Jenny Young, Jason Chen, Wendy Abulafia, Paul Keast, Charles K. Marlowe, Wentao Zhang, Christopher T. Jaeger, Peiwen Yu, Kwang-Ai Won, Jianming Wu, Xiangnan Du, Fawn Qian, Pin P. Hsu, Kyoko Yamaguchi, Paul Foster
Effects of XL147 on PI3K Signaling Pathway in EGF-Stimulated PC-3 Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9669a150af5e5be12d3299122d031454
https://doi.org/10.1158/1535-7163.22501293.v1
https://doi.org/10.1158/1535-7163.22501293.v1
Autor:
Mark Rolfe, Daniel J. Anderson, Constantine S. Mitsiades, Jeffrey L. Wolf, Thomas G. Martin, Han-Jie Zhou, Laura Shawver, David Wustrow, F. Michael Yakes, Szerenke Kiss Von Soly, Christoph Driessen, Marianne Kraus, P. Leif Bergsagel, Marta Chesi, Jinhai Wang, Julie Rice, Christine Lam, Arun P. Wiita, Bing Yao, Grace J. Lee, Stephen T. Wong, Zhi Yong Wu, Mary-Kamala Menon, Ferdie Soriano, Emily M. King, Megan Murnane, Eduardo Valle, Eugen Dhimolea, Stevan Djakovic, Blake T. Aftab, Ronan Le Moigne
Supplementary Figure S1:Effect of CB-5083 on cell growth and survival in multiple myeloma and solid tumor cell lines; Supplementary Figure S2:CB-5083 activates UPR;Supplementary Figure S3:CB-5083 transcriptional response is unique in comparison to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569299e78d46c92329042958fa03bafc
https://doi.org/10.1158/1535-7163.22509273
https://doi.org/10.1158/1535-7163.22509273
Autor:
A. Douglas Laird, Peter Lamb, David J. Matthews, Olivia Yturralde, Stephanie Dale, Sanh T. Lam, Frauke Bentzien, Kelly Engell, Felix Chu, F. Michael Yakes, Artur Plonowski, Jenny Young, Jason Chen, Wendy Abulafia, Paul Keast, Charles K. Marlowe, Wentao Zhang, Christopher T. Jaeger, Peiwen Yu, Kwang-Ai Won, Jianming Wu, Xiangnan Du, Fawn Qian, Pin P. Hsu, Kyoko Yamaguchi, Paul Foster
Effects of XL147 on PI3K Pathway Signaling in A549, MDA-MB-468 and LS174T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a3f60276d69e7049037ddfa915cc5a
https://doi.org/10.1158/1535-7163.22501284
https://doi.org/10.1158/1535-7163.22501284
Autor:
A. Douglas Laird, Peter Lamb, David J. Matthews, Olivia Yturralde, Stephanie Dale, Sanh T. Lam, Frauke Bentzien, Kelly Engell, Felix Chu, F. Michael Yakes, Artur Plonowski, Jenny Young, Jason Chen, Wendy Abulafia, Paul Keast, Charles K. Marlowe, Wentao Zhang, Christopher T. Jaeger, Peiwen Yu, Kwang-Ai Won, Jianming Wu, Xiangnan Du, Fawn Qian, Pin P. Hsu, Kyoko Yamaguchi, Paul Foster
Assessment of effects of XL147 on Nutrient-Dependent mTOR Signaling Pathway in Ramos cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777dcba04ed9652416df56917277426b
https://doi.org/10.1158/1535-7163.22501290.v1
https://doi.org/10.1158/1535-7163.22501290.v1
Autor:
Alison H. Joly, Yu-Chien Chou, Justin Lesch, Lillian Lee, Stefan Engst, A. Douglas Laird, Andrew You, Jessica Orf, Belinda Cancilla, Frauke Bentzien, Felix Chu, Fawn Qian, Peiwen Yu, Yongchang Shi, Kyoko Yamaguchi, Jenny Tan, Jason Chen, F. Michael Yakes
The signaling pathway of the receptor tyrosine kinase MET and its ligand hepatocyte growth factor (HGF) is important for cell growth, survival, and motility and is functionally linked to the signaling pathway of VEGF, which is widely recognized as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c0549987b6953fbcc1b2686b81a276
https://doi.org/10.1158/1535-7163.c.6535348
https://doi.org/10.1158/1535-7163.c.6535348
Autor:
Mark Rolfe, Daniel J. Anderson, Constantine S. Mitsiades, Jeffrey L. Wolf, Thomas G. Martin, Han-Jie Zhou, Laura Shawver, David Wustrow, F. Michael Yakes, Szerenke Kiss Von Soly, Christoph Driessen, Marianne Kraus, P. Leif Bergsagel, Marta Chesi, Jinhai Wang, Julie Rice, Christine Lam, Arun P. Wiita, Bing Yao, Grace J. Lee, Stephen T. Wong, Zhi Yong Wu, Mary-Kamala Menon, Ferdie Soriano, Emily M. King, Megan Murnane, Eduardo Valle, Eugen Dhimolea, Stevan Djakovic, Blake T. Aftab, Ronan Le Moigne
Inhibition of the AAA ATPase, p97, was recently shown to be a novel method for targeting the ubiquitin proteasome system, and CB-5083, a first-in-class inhibitor of p97, has demonstrated broad antitumor activity in a range of both hematologic and sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9c3a3608da1883962d4e516df699248
https://doi.org/10.1158/1535-7163.c.6539250.v1
https://doi.org/10.1158/1535-7163.c.6539250.v1