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Pembrolizumab, Ipilimumab and Nivolumab reduces cardiac pAMPK and IL-10, increases vascular NF-kB expression and levels of IL-1b, IL-2 and IL-6 in myocardial tissue

Autor: N Maurea, C De Lorenzo, M Passariello, M Iovine, S Buccolo, A Di Mauro, C Cipullo, A Paccone, F Maurea, A Caronna, V Quagliariello

Publikováno v: European Heart Journal. 43

Background Several strategies based on immune checkpoint inhibitors (ICIs) have been developed or are under investigation for cancer therapy, opening to advantages in cancer outcomes. However, several ICIs-induced side effects emerged in these patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d36c08db71e8d41e391330a7a7e424d
https://doi.org/10.1093/eurheartj/ehac544.2728

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P470 BERBERINE ASSOCIATED TO DAPAGLIFLOZIN EXERTS SYNERGISTIC CARDIOPROTECTIVE EFFECTS IN CARDIAC CELLS EXPOSED TO THE HER2–BLOKING AGENT TRASTUZUMAB THROUGH PAMPK ACTIVATION AND REDUCTION IN INTERLEUKIN–6 LEVELS

Autor: V Quagliariello, M Scherillo, F Maurea, M Iovine, A Paccone, N Maurea

Publikováno v: European Heart Journal Supplements. 25:D227-D227

Background Trastuzumab has improved the prognosis in patients with HER2–positive breast cancer, but it can induce left ventricular dysfunction with reduced ejection fraction or HF during treatment. Dapagliflozin is a SGLT2i with cardio–renal bene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e73511e157f494d7775827206e2dc409
https://doi.org/10.1093/eurheartjsupp/suad111.532

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C7 COMBINATION OF SPIRULINA, GANODERMA LUCIDUM AND MORINGA OLEIFERA IMPROVES CARDIAC FUNCTIONS AND REDUCES PRO–INFLAMMATORY BIOMARKERS IN PRECLINICAL MODELS OF SHORT–TERM DOXORUBICIN–MEDIATED CARDIOTOXICITY

Autor: V Quagliariello, C Ostacolo, R De Anseris, A Di Mauro, G Scognamiglio, G Palma, M Iovine, A Luciano, M Barbieri, F Bruzzese, F Maurea, A Paccone, M Berretta, N Maurea

Publikováno v: European Heart Journal Supplements. 25:D3-D3

Background Anthracyclines are essential adjuvant therapies for a variety of cancers, particularly breast, and gastric and esophageal cancers. Whilst prolonging cancer–related survival, these agents can in–duce drug–related cardiotoxicity. Spiru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf0c9a68f8afa03638d8b08264af99d6
https://doi.org/10.1093/eurheartjsupp/suad111.007

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14P Sacubitril-valsartan increases pAMPK and reduces NLRP3, MyD88, interleukin-6 and galectin-3 in short-term doxorubicin-treated mice improving longitudinal strain and ejection fraction

Autor: A. Caronna, V. Quagliariello, S. Buccolo, F. Maurea, A. Luciano, A. Barbieri, G. Palma, A. Paccone, N. Maurea

Publikováno v: Annals of Oncology. 33:S550

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dea476a9c7fb3f3103edc6bf976281a
https://doi.org/10.1016/j.annonc.2022.07.042

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