Zobrazeno 1 - 10
of 114
pro vyhledávání: '"F M Sirotnak"'
Publikováno v:
ChemInform. 23
Previous findings suggesting that 5,10-dialkyl-substituted derivatives of 5,10-dideazaaminopterin warranted study as potential antifolates prompted synthesis of 10-ethyl-5-methyl-5,10- dideazaaminopterin (12a). The key step in the synthetic route to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0946948743b8d9cb11c0c9fb179341
https://doi.org/10.1002/chin.199252219
https://doi.org/10.1002/chin.199252219
Autor:
Yuhong, She, Fei, Lee, Jing, Chen, Adriana, Haimovitz-Friedman, Vincent A, Miller, Valerie R, Rusch, Mark G, Kris, F M, Sirotnak
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(10 Pt 1)
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) markedly potentiates the efficacy of many cytotoxic agents against several human cancer xenografts, irrespective of tumor EGFR expression levels. We subsequently investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::605b9ffacdd7261dbdbb8160fc48e70d
https://pubmed.ncbi.nlm.nih.gov/14506170
https://pubmed.ncbi.nlm.nih.gov/14506170
Autor:
Lee M, Krug, Christopher G, Azzoli, Mark G, Kris, Vincent A, Miller, Nushmia Z, Khokhar, William, Tong, Michelle S, Ginsberg, Ennapadam, Venkatraman, Leslie, Tyson, Barbara, Pizzo, Valerie, Baez, Kenneth K, Ng, F M, Sirotnak
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(6)
10-propargyl-10-deazaaminopterin (PDX) has superior antitumor efficacy in mouse xenograft models, likely attributable to increased uptake by the RFC-1 folate transporter and greater intracellular polyglutamylation. In a previous Phase I trial, stomat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f1c7b2477a3bf4edcb77e79f5fdf7c5
https://pubmed.ncbi.nlm.nih.gov/12796370
https://pubmed.ncbi.nlm.nih.gov/12796370
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(12)
CPT-11, a DNA topoisomerase I inhibitor, has demonstrated clinical activity in colorectal cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, is rapidly emerging as a chemotherapy modulator. To enhance the therapeutic index of CPT-11 in colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c72fcce4bd83fd6d0f16ebd4084f973e
https://pubmed.ncbi.nlm.nih.gov/11751522
https://pubmed.ncbi.nlm.nih.gov/11751522
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)
Studies described here sought to evaluate the therapeutic potential of a new 10-deazaaminopterin analogue, 10-propargyl-10-deazaaminopterin (PDX), alone and in combination with platinum compounds in the treatment of human pleural mesothelioma. In vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1840b2f81ad90932691b7d03a8b36727
https://pubmed.ncbi.nlm.nih.gov/11595715
https://pubmed.ncbi.nlm.nih.gov/11595715
Publikováno v:
Gene. 268(1-2)
Analysis of independently isolated clones from a mouse liver cDNA library identified a splice variant of gamma-GH mRNA with novel nucleotide sequence at the 5' end. Genomic sequencing now shows that this variant (variant II) incorporates two new alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::294860f0dc0f7bc78eaee1fe6405250a
https://pubmed.ncbi.nlm.nih.gov/11368914
https://pubmed.ncbi.nlm.nih.gov/11368914
Publikováno v:
European journal of medicinal chemistry. 36(3)
N-[4-[[2,4-diamino-6-pteridinyl)methyl]amino]bicyclo[2.2.2]octane-1-carbonyl]-L-glutamic acid (1) was synthesized and tested for antifolate activity. N-(4-Aminobicyclo[2.2.2]octane-1-carbonyl-L-glutamic acid dimethyl ester (6), the side chain precurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::160aa55540f20db7c2d03c156c657744
https://pubmed.ncbi.nlm.nih.gov/11337102
https://pubmed.ncbi.nlm.nih.gov/11337102
Autor:
S A, Laurie, D G, Pfister, M G, Kris, W P, Tong, G, Chronowski, K M, Pisters, R T, Heelan, F M, Sirotnak
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(3)
The antifolate edatrexate has shown moderate activity against cancers of the head and neck and non-small cell lung cancer, as has cisplatin. Edatrexate demonstrates synergy with cisplatin in transplanted tumor models. This Phase I study was designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9f9d12637404f78afefc7a87f85745e
https://pubmed.ncbi.nlm.nih.gov/11297240
https://pubmed.ncbi.nlm.nih.gov/11297240
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(12)
The blockade of epidermal growth factor receptor (EGFR) function with monoclonal antibodies has major antiproliferative effects against human tumors in vivo. Similar antiproliferative effects against some of these same tumors have also been observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::540f5354a0ce66c60ed821733e20d7a7
https://pubmed.ncbi.nlm.nih.gov/11156248
https://pubmed.ncbi.nlm.nih.gov/11156248
Autor:
Stanley A. Rubin, Larry H. Matherly, Riaz Ul Haq, Veedamali S. Subramanian, Hamid M. Said, Nabendu S. Chatterjee, Charles H. Halsted, F. M. Sirotnak, Alvaro Ortiz
Publikováno v:
American journal of physiology. Cell physiology. 279(6)
Folate is an essential micronutrient that, in mammals, must be obtained from exogenous sources via intestinal absorption. Previous studies have characterized different aspects of the mechanism of the intestinal folate uptake process. Much less, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e27a40ec854dcace402637a99e5c660
https://pubmed.ncbi.nlm.nih.gov/11078704
https://pubmed.ncbi.nlm.nih.gov/11078704