Zobrazeno 1 - 4
of 4
pro vyhledávání: '"F M S de Vrij"'
Autor:
Jeffrey Stedehouder, Albert Hofman, W F J van IJcken, Harry L A Janssen, A.G. Uitterlinden, Rutger W W Brouwer, Henning Tiemeier, Robert Kraaij, C M van Duijn, F M S de Vrij, Najaf Amin, S. Darwish Murad, M C G N van den Hout, Johan M. Kros, Steven A. Kushner, M Baghdadi, O. Jovanova, J. van Rooij
Publikováno v:
Molecular Psychiatry, 23(5), 1120-1126. Nature Publishing Group
Molecular Psychiatry
Molecular Psychiatry
Depression is the most prevalent psychiatric disorder with a complex and elusive etiology that is moderately heritable. Identification of genes would greatly facilitate the elucidation of the biological mechanisms underlying depression, however, its
Autor:
Meike W. Vernooij, Henning Tiemeier, F M S de Vrij, W F J van IJcken, M. A. Ikram, Rutger W W Brouwer, Wiro J. Niessen, Robin P. Peeters, O. Jovanova, J. van Rooij, E. C. M. van Leeuwen, Layal Chaker, K. Willems van Dijk, Hieab H.H. Adams, Najaf Amin, C M van Duijn, Ayse Demirkan, Steven A. Kushner, S. J. van der Lee, André G. Uitterlinden, Robert Kraaij, Maryam Kavousi, Abbas Dehghan, Albert Hofman, Thomas Hankemeier, Oscar H. Franco
Publikováno v:
Molecular Psychiatry, 22(4), 537-543
Molecular Psychiatry, 22(4), 537-543. Nature Publishing Group
Amin, N, Jovanova, O, Adams, H H H, Dehghan, A, Kavousi, M, Vernooij, M W, Peeters, R P, De Vrij, F M S, Van Der Lee, S J, Van Rooij, J G J, Van Leeuwen, E M, Chaker, L, Demirkan, A, Hofman, A, Brouwer, R W W, Kraaij, R, Willems Van DIjk, K, Hankemeier, T, Van Ijcken, W F J, Uitterlinden, A G, Niessen, W J, Franco, O H, Kushner, S A, Ikram, M A, Tiemeier, H & Van Duijn, C M 2017, ' Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms ', Molecular Psychiatry, vol. 22, no. 4, pp. 537-543 . https://doi.org/10.1038/mp.2016.101
Molecular Psychiatry, 22(4), 537-543. Nature Publishing Group
Amin, N, Jovanova, O, Adams, H H H, Dehghan, A, Kavousi, M, Vernooij, M W, Peeters, R P, De Vrij, F M S, Van Der Lee, S J, Van Rooij, J G J, Van Leeuwen, E M, Chaker, L, Demirkan, A, Hofman, A, Brouwer, R W W, Kraaij, R, Willems Van DIjk, K, Hankemeier, T, Van Ijcken, W F J, Uitterlinden, A G, Niessen, W J, Franco, O H, Kushner, S A, Ikram, M A, Tiemeier, H & Van Duijn, C M 2017, ' Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms ', Molecular Psychiatry, vol. 22, no. 4, pp. 537-543 . https://doi.org/10.1038/mp.2016.101
Despite a substantial genetic component, efforts to identify common genetic variation underlying depression have largely been unsuccessful. In the current study we aimed to identify rare genetic variants that might have large effects on depression in
Autor:
A.G. Uitterlinden, W F J van IJcken, M C G N van den Hout, F M S de Vrij, Robert Kraaij, Steven A. Kushner, Johan M. Kros, Rutger W W Brouwer, Harry L.A. Janssen, J. van Rooij, C M van Duijn, Henning Tiemeier, Jeffrey Stedehouder, S. Darwish Murad, Najaf Amin, Albert Hofman, O. Jovanova, M Baghdadi
Publikováno v:
Molecular Psychiatry, 23(5), 1093-1093. Nature Publishing Group
Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort
Publikováno v:
Progress in neurobiology. 74(5)
The ubiquitin proteasome system (UPS) is the major protein quality control system in eukaryotic cells. Many neurodegenerative diseases are characterized by aggregates and inclusions of aberrant proteins, implying a sub-optimal functioning or defectiv